LABORATORY RESEARCH Selective Killing of Cancer Cells by a Small Molecule Targeting the Stress Response to Reactive Oxygen Species Scientists used a cell-based small-molecule screening and quantitative proteomics approach that resulted in the unbiased identification of a small molecule that selectively kills cancer cells but not normal cells. [Nature] Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer Through analysis of the androgen receptor (AR) cistrome and androgen-regulated gene expression in estrogen receptor negative/HER2 positive breast cancers researchers found that AR mediates ligand-dependent activation of Wnt and HER2 signaling pathways through direct transcriptional induction of WNT7B and HER3. [Cancer Cell] Engagement of I-Branching β-1, 6-N-Acetylglucosaminyltransferase 2 in Breast Cancer Metastasis and TGF-β Signaling In this study, investigators have showed that GCNT2, a gene-encoding glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and mouse origin and basal-like breast tumor samples. [Cancer Res] p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage In this study, scientists investigated the mechanisms of p53-dependent BRCA1 subcellular distribution and DNA damage-induced nuclear export, as well as the impact on the resulting cytotoxic response to therapy in human breast cancer. [Cancer Res] Overexpression of 14-3-3ζ in Cancer Cells Activates PI3K via Binding the p85 Regulatory Subunit Researchers investigated the clinical relevance and molecular mechanism of 14-3-3ζ-overexpression-mediated Akt phosphorylation, and its potential impact on breast cancer progression. [Oncogene] Hypoxia Inducible Factor-1 Is Activated by Dysregulated Cyclin E During Mammary Epithelial Morphogenesis Investigators have studied dysregulated cyclin E in epithelial tissues using organotypic cultures of human mammary epithelial cells and a murine model. [Mol Cell Biol] Comparative Gene Expression Analysis in Mouse Models for Identifying Critical Pathways in Mammary Gland Development In this article, scientists applied a standardized microarray preprocessing to four independent studies, and then used gene set enrichment analysis to identify the key pathways. [Breast Cancer Res Treat] CLINICAL RESEARCH Increased Risk of Locoregional Recurrence for Women with T1-2N0 Triple-Negative Breast Cancer Treated with Modified Radical Mastectomy without Adjuvant Radiation Therapy Compared with Breast-Conserving Therapy The purpose of this study is to evaluate the risk of locoregional recurrence associated with locoregional treatment of women with primary breast cancer tumors negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (triple-negative breast cancer). [J Clin Oncol] Phase I/II Study of Trastuzumab in Combination with Everolimus (RAD001) in Patients with HER2-Overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-Based Therapy The trial evaluated the safety and efficacy of the combination of everolimus and trastuzumab in women with HER2-overexpressing metastatic breast cancer that progressed on trastuzumab-based therapy. [J Clin Oncol] Fluoroestradiol Positron Emission Tomography Reveals Differences in Pharmacodynamics of Aromatase Inhibitors, Tamoxifen, and Fulvestrant in Patients with Metastatic Breast Cancer The purpose of this study is to determine, by molecular imaging, how in vivo pharmacodynamics of estrogen-estrogen receptor binding differ between types of standard endocrine therapy. [Clin Cancer Res] Functional Polymorphisms in UDP-Glucuronosyltransferases and Recurrence in Tamoxifen-Treated Breast Cancer Survivors Investigators measured the association between functional polymorphisms in key UDP-glucuronosyltransferases (UGT2B15*2, UGT2B7*2, and UGT1A8*3) and the recurrence rate among breast cancer survivors. [Cancer Epidemiol Biomarkers Prev] |