LABORATORY RESEARCH Postpartum Mammary Gland Involution Drives Progression of Ductal Carcinoma In Situ Through Collagen and Cyclooxygenase-2 Here researchers describe a mouse model of postpartum breast cancer that identifies mammary gland involution as a driving force of tumor progression. [Nat Med] Genome-Wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, investigators performed a genome-wide methylation array analysis on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. [Cancer Res] Lineage Specific Methylation of the Elf5 Promoter in Mammary Epithelial Cells Scientists used bisulphite sequencing to investigate in detail whether Elf5 promoter methylation plays a role in lineage commitment during mammary development. [Stem Cells] Sox2 Expression in Breast Tumors and Activation in Breast Cancer Stem Cells Expression of pluripotency genes (Oct4, Nanog and Sox2) was tested in breast tumors by immunohistochemistry and it was found that Sox2 is expressed in early stage breast tumors. [Oncogene] Functional Interactions Between Choline Kinase α, Epidermal Growth Factor Receptor and c-Src in Breast Cancer Cell Proliferation In this report, researchers found that choline kinase α forms a complex with epidermal growth factor receptor in a c-Src-dependent manner. [Oncogene] CYP2S1 and CYP2W1 Mediate 2-(3,4-Dimethoxyphenyl)-5-Fluorobenzothiazole (GW 610, NSC 721648) Sensitivity in Breast and Colorectal Cancer Cells Here, scientists investigate the functional role of 2 newly identified cytochrome P450 enzymes, CYP2S1 and CYP2W1, in mediating antitumor activity of benzothiazole compounds. [Mol Cancer Ther] Lrig1 Is an Estrogen Regulated Growth Suppressor and Correlates with Longer Relapse Free Survival in ER-α Positive Breast Cancer To gain a better understanding of the role of Lrig1 in breast cancer, investigators examined its expression in estrogen receptor alpha (ERα)-positive disease. [Mol Cancer Res] CLINICAL RESEARCH Leukocyte Composition of Human Breast Cancer Data provided an initial evaluation of differences in the immune microenvironment of breast cancer compared with nonadjacent normal tissue and revealed the degree to which chemotherapy may alter the complexity and presence of selective subsets of immune cells in tumors previously treated in the neoadjuvant setting. [Proc Natl Acad Sci U S A] Trastuzumab-Related Cardiotoxicity in the Elderly: A Role for Cardiovascular Risk Factors Elderly breast cancer patients with a history of cardiac disease and/or diabetes treated with trastuzumab have an increased incidence of cardiotoxicity. [Ann Oncol] |