Mammary Cell News Volume 3.35 | Sep 8 2011

LABORATORY RESEARCH

BRCA1 Tumor Suppression Occurs Via Heterochromatin-Mediated Silencing
Here scientists show that loss of Brca1 in mice results in transcriptional de-repression of the tandemly repeated satellite DNA. [Nature] Abstract | Press Release

Transcription Factor Dlx2 Protects from TGFβ-Induced Cell-Cycle Arrest and Apoptosis
Acquiring resistance against transforming growth factor β (TGFβ)-induced growth inhibition at early stages of carcinogenesis and shifting to TGFβ’s tumor-promoting functions at later stages is a pre-requisite for malignant tumor progression and metastasis. Investigators have identified the transcription factor distal-less homeobox 2 (Dlx2) to exert critical functions during this switch. [EMBO J] Abstract

GATA3 Inhibits Lysyl Oxidase-Mediated Metastases of Human Basal Triple-Negative Breast Cancer Cells
Scientists demonstrate through gene expression profiling that GATA3 expression in 231 cells resulted in the dramatic reduction in the expression of lysyl oxidase (LOX), a metastasis-promoting, matrix-remodeling protein, in part, through methylation of the LOX promoter. [Oncogene] Abstract

An Integrated Genomic Approach Identifies ARID1A as a Candidate Tumor-Suppressor Gene in Breast Cancer
Researchers combined inhibition of the nonsense-mediated RNA decay process with the application of high-density single-nucleotide polymorphism arrays analysis to discriminate allelic content in order to identify candidate tumor-suppressor genes in five breast cancer cell lines. [Oncogene] Abstract

Role of Src in Breast Cancer Cell Migration and Invasion in a Breast Cell/Bone-Derived Cell Microenvironment
In this study, an in vitro co-culture system composed of bone mesenchymal stem cells and breast cancer cell lines is used to examine the role of Src kinase on breast cancer cell migration and invasion in the presence of bone-derived cells. [Breast Cancer Res Treat] Abstract

Rapid Non-Genomic Signaling by 17β-Oestradiol through c-Src Involves Mammalian Target of Rapamycin-Dependent Expression of HIF-1α in Breast Cancer Cells
In this study, investigators demonstrate that exposure of human breast cancer lines to 17β-oestradiol rapidly induced the expression of hypoxia-inducible factor 1α (HIF-1α), the regulated subunit of HIF1, in normoxic condition. [Br J Cancer] Abstract

Lysophosphatidic Acid-Induced p21Waf1 Expression Mediates the Cytostatic Response of Breast and Ovarian Cancer Cells to Transforming Growth Factor Beta
In the present study, scientists showed that lysophosphatidic acid upregulated expression of the cyclin-dependent kinase inhibitor p21Waf1 in transforming growth factor beta (TGFβ)-sensitive breast and ovarian cancer cells, but not in TGFβ-resistant ones. [Mol Cancer Res] Abstract

CLINICAL RESEARCH

Response to Neoadjuvant Systemic Therapy for Breast Cancer in BRCA Mutation Carriers and Noncarriers: A Single-Institution Experience
The purpose of this study is to compare the pathologic complete response rate and relapse-free survival and overall survival after neoadjuvant systemic chemotherapy in patients with breast cancer with and without deleterious BRCA1 and BRCA2 mutations. [J Clin Oncol] Abstract | Press Release

Age, Breast Cancer Subtype Approximation, and Local Recurrence After Breast-Conserving Therapy
Researchers studied 1,434 consecutive patients with invasive breast cancer who received breast-conserving therapy from December 1997 to July 2006. [J Clin Oncol] Abstract

The Breakthrough Generations Study: Design of a Long-Term UK Cohort Study to Investigate Breast Cancer Etiology
The rationale, design, recruitment and follow-up methods are described for the Breakthrough Generations Study, a UK cohort study started in 2003, targeted at investigation of breast cancer etiology. [Br J Cancer] Abstract

Nanoscale Targeting May Improve Breast Cancer Treatment
Xiaoting Zhang, PhD recently secured a $587,000 U.S. Department of Defense Breast Cancer Idea Award to develop tissue-specific nanotherapeutics for the treatment of human breast cancer. [University of Cincinnati Academic Health Center] Press Release
 
Indiana University’s Bryan Schneider Receives Conquer Cancer Foundation Award in Support of Research on New Biomarker in Breast Cancer Patients
The Conquer Cancer Foundation of the American Society of Clinical Oncology announced Bryan P. Schneider, MD, as the recipient of the 2011 Advanced Clinical Research Award in Breast Cancer. [American Society of Clinical Oncology] Press Release

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NEW 1st International Conference on Stem Cell Research and Applications
October 7-9, 2011
Kayseri, Turkey

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