LABORATORY RESEARCH Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14 In this study, investigators report that JARID1B is a physical component of the LSD1/NuRD complex that functions in transcriptional repression. [Cancer Res] Abstract Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK-Cells Recognition Scientists studied whether breast cancer subtypes might have different susceptibility to NK-cells anti-tumor immunity. [Cancer Res] Abstract The New Truncated Somatostatin Receptor Variant sst5TMD4 Is Associated to Poor Prognosis in Breast Cancer and Increases Malignancy in MCF-7 Cells Here, scientists investigated the possible role of sst5TMD4 in breast cancer. [Oncogene] Abstract Gadolinium Metallofullerenol Nanoparticle Inhibits Cancer Metastasis through Matrix Metalloproteinase Inhibition: Prison Instead of Poison Cancer Cells The purpose of this work is to study the anti-metastasis activity of Gd@C82(OH)22 metallofullerenol nanoparticles in malignant and invasive human breast cancer models. [Nanomedicine] Abstract Suppression of Apoptosis Inhibitor c-FLIP Selectively Eliminates Breast Cancer Stem Cell Activity in Response to the Anti-Cancer Agent, TRAIL In order to identify strategies to selectively remove breast cancer stem cells (bCSCs) from breast cancers, irrespective of their clinical subtype, investigators sought an apoptosis mechanism that would target bCSCs yet would not kill normal cells. [Breast Cancer Res] Abstract CDDO-Methyl Ester Delays Breast Cancer Development in BRCA1-Mutated Mice Because the methyl ester of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) is a potent chemopreventive agent, researchers tested its efficacy in a highly relevant mouse model of BRCA1-mutated breast cancer. [Cancer Prev Res] Abstract Neuropeptide Y Stimulates Proliferation and Migration in the 4T1 Breast Cancer Cell Line The specific aims of the current study were to characterize norepinephrine and neuropeptide Y (NPY) receptor expression in 4T1 breast cancer cells and orthotopic tumors grown in BALB/c mice and investigate the impact of NPY receptor activation on 4T1 cell proliferation and migration in vitro. [Int J Cancer] Abstract | Press Release Differential Turnover of Myosin Chaperone UNC-45A Isoforms Increases in Metastatic Human Breast Cancer Here, investigators show that UNC-45A mRNA and protein expression was elevated in human breast carcinomas and cell lines derived from breast carcinoma metastases. [J Mol Biol] Abstract | Press Release Alcohol Metabolism in Human Cells Causes DNA Damage and Activates the Fanconi Anemia–Breast Cancer Susceptibility (FA-BRCA) DNA Damage Response Network To determine whether intracellular generation of acetaldehyde from ethanol metabolism can cause DNA damage and activate the FA-BRCA network, scientists engineered HeLa cells to metabolize alcohol by expression of human alcohol dehydrogenase 1B. [Alcohol Clin Exp Res] Abstract | Press Release CLINICAL RESEARCH Relationship Between Quantitative GRB7 RNA Expression and Recurrence After Adjuvant Anthracycline Chemotherapy in Triple Negative Breast Cancer The purpose of this study is to perform an exploratory analysis of the relationship between gene expression and recurrence in patients with operable triple negative breast cancer treated with adjuvant doxorubicin-containing chemotherapy. [Clin Cancer Res] Abstract MutYH Mutation Carriers Have Increased Breast Cancer Risk The authors studied the risk of breast cancer associated with MutYH variants in a unique ethnic group of Sephardi Jews in Israel with a high prevalence of MutYH mutations. [Cancer] Abstract |