Mammary Cell News Volume 3.49 | Dec 15 2011

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
To identify pathways supporting the Myc oncogenic program, scientists used a genome-wide RNAi screen to search for Myc-synthetic lethal genes and uncovered a role for the SUMO-activating enzyme. [Science] Abstract | Press Release

Upregulation of miR-1245 by c-Myc Targets BRCA2 and Impairs DNA Repair
In this study, researchers demonstrated that miR-1245 directly suppressed BRCA2 3’-UTR and translation, impaired homologous recombination-mediated repair, reduced DNA damage-induced Rad51 nuclear foci and rendered cells hypersensitive to γ-irradiation, ultimately inducing high chromosomal abnormalities in normal breast cells and breast cancer cells. [J Mol Cell Biol] Abstract

Immune Recognition of Tumor-Associated Mucin MUC1 Is Achieved by a Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccine
Investigators have identified the minimum requirements to consistently induce cytotoxic T lymphocytes and antibody-dependent cell-mediated cytotoxicity-mediating antibodies specific for the tumor form of MUC1 resulting in a therapeutic response in a mouse model of mammary cancer. [Proc Natl Acad Sci USA]
Abstract | Press Release

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways
Here, scientists report the consequences of psoriasin (S100A7)’s expression on inflammatory pathways that impact breast cancer growth. [Cancer Res] Abstract

A Pharmacological Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth
In this study, researchers developed and evaluated small molecule inhibitors of Taspase1 as a new candidate class of therapeutic modalities. [Cancer Res] Abstract

Proyl Isomerase Pin1 Facilitates Ubiquitin-Mediated Degradation of Cyclin-Dependent Kinase 10 to Induce Tamoxifen Resistance in Breast Cancer Cells
The aim of this study was to elucidate the mechanisms by which downregulation of CDK10 expression confers resistance to tamoxifen in breast cancer. [Oncogene] Abstract

MicroRNA-520/373 Family Functions as a Tumor Suppressor in Estrogen Receptor Negative Breast Cancer by Targeting NF-κB and Transforming Growth Factor-β Signaling Pathways
Here, investigators performed an unbiased whole genome microRNA (miRNA) screen to identify novel modulators of nuclear factor κB (NF-κB) pathway in breast cancer. [Oncogene] Abstract

Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally-Regulated Gene Signature Related to Clinical Letrozole Responsiveness
The purpose of this study is to assess the clinical significance of the interaction between estrogen and Runx2 signaling, previously demonstrated in vitro. [Clin Cancer Res] Abstract

Regulation of Sodium Iodide Symporter Gene Expression by the Rac1/p38β MAP Kinase Signaling Pathway in MCF-7 Breast Cancer Cells
To identify a signal transduction pathway that selectively stimulates sodium/iodide symporter gene expression, scientists investigated regulation by the Rac1-p38 signaling pathway in MCF-7 breast cancer cells and compared it with regulation in FRTL-5 rat thyroid cells. [J Biol Chem] Abstract

Matrix Compliance and RhoA Direct the Differentiation of Mammary Progenitor Cells
Here, investigators examined how the mechanical properties of the microenvironment affect the differentiation of mammary progenitor cells. [Biomech Model Mechanobiol] Abstract

CLINICAL RESEARCH

Prognostic Effect of Circulating Adiponectin in a Randomized 2 × 2 Trial of Low-Dose Tamoxifen and Fenretinide in Premenopausal Women at Risk for Breast Cancer
Scientists investigated the associations of plasma leptin and adiponectin with mammographic density and disease status and assessed their prognostic effect on recurrence-free survival in premenopausal women at risk for breast cancer. [J Clin Oncol] Abstract

Intravenous or Oral Vinorelbine Plus Capecitabine as First-Line Treatment in HER2-Metastatic Breast Cancer: Joint Analysis of 2 Consecutive Prospective Phase II Trials
The purpose of this study was to assess the activity and safety of the combination of vinorelbine and capecitabine as first-line treatment in HER2-negative metastatic breast cancer. [Clin Breast Cancer] Abstract

First Genome Sequencing Clinical Trial for Triple Negative Cancer Points to New Treatments
Initial results from an ongoing clinical trial, the first designed to examine the utility of whole-genome sequencing for triple negative breast cancer, were reported. [Press release from The Translational Genomics Research Institute discussing research presented at the 2011 CTR-AACR San Antonio Breast Cancer Symposium, San Antonio] Press Release

Circulating Tumor Cells Not Linked to Survival in Women Newly Diagnosed with Inflammatory Breast Cancer
The presence of circulating tumor cells in the blood appears to have no relationship to survival in women who have just been diagnosed with inflammatory breast cancer, according to new research. [Press release from Fox Chase Cancer Center discussing research presented at the 2011 CTR-AACR San Antonio Breast Cancer Symposium, San Antonio] Press Release

Loss of RB in Triple Negative Breast Cancer Associated with Favorable Clinical Outcome
Researchers have shown that loss of the retinoblastoma tumor suppressor gene (RB) in triple negative breast cancer patients is associated with better clinical outcomes. [Press release from Thomas Jefferson University Kimmel Cancer Center discussing research presented at the 2011 CTR-AACR San Antonio Breast Cancer Symposium, San Antonio] Press Release

Gene Inheritance Patterns Influence Age of Diagnosis in BRCA Families
Women who inherit the cancer genes BRCA1 or BRCA2 from their paternal lineage may get a diagnosis a decade earlier than those women who carry the cancer genes from their mother and her ancestors, according to a new study. [Press release from North Shore-Long Island Jewish Health System discussing research presented at the 2011 CTR-AACR San Antonio Breast Cancer Symposium, San Antonio] Press Release

New Test to Indicate Likely Spread or Recurrence of Breast Cancer
A PhD student has developed a potential breakthrough test for predicting the likelihood of the spread or return of breast cancer. [Queensland University of Technology] Press Release

Maryland Stem Cell Research Commission Issues Supplement to FY 2012 RFAs – Collaborative Research Opportunity with the California Institute for Regenerative Medicine
Maryland Stem Cell Research Commission Issues Supplement to FY 2012 RFAs – Collaborative Research Opportunity with the California Institute for Regenerative Medicine [Maryland Stem Cell Research Fund]
Press Release

Molecular Imaging, Inc. Enters Relationship with Dana-Farber Cancer Institute to Expand Luciferase-Reporter Cancer Cell Lines for Preclinical In Vivo Imaging
Molecular Imaging, Inc. announced that it has entered into a licensing agreement with Dana-Farber Cancer Institute to access a substantial number of luciferase-enabled cancer cell lines developed at Dana-Farber. [PR Newswire] Press Release

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