Mammary Cell News Volume 4.02 | Jan 19 2012

LABORATORY RESEARCH

The Splicing Factor SRSF1 Regulates Apoptosis and Proliferation to Promote Mammary Epithelial Cell Transformation
Researchers investigated the ability of serine/arginine-rich splicing factor 1 (SRSF1) to transform human and mouse mammary epithelial cells in vivo and in vitro. [Nat Struct Mol Biol] Abstract

The Resistance of Breast Cancer Stem Cells to Conventional Hyperthermia and Their Sensitivity to Nanoparticle-Mediated Photothermal Therapy
Breast cancer stem cells (BCSCs), which are refractory to chemotherapy and radiotherapy, are thought to persist following treatment and drive tumor recurrence. Researchers examined whether BCSCs are similarly resistant to hyperthermic therapy, and whether nanoparticles could be used to overcome this resistance. [Biomaterials] Abstract

FOXC1 Regulates the Functions of Human Basal-Like Breast Cancer Cells by Activating NF-κB Signaling
Here researchers show that FOXC1 activates the transcription factor nuclear factor-κB (NF-κB) in basal-like breast cancer cells by increasing p65/RelA protein stability. [Oncogene] Abstract

Hepatoma-Derived Growth Factor Regulates Breast Cancer Cell Invasion by Modulating Epithelial Mesenchymal Transition
In this study, researchers set out to elucidate the expression profile and function of hepatoma-derived growth factor during breast carcinogenesis. [J Pathol] Abstract

Molecular Profiling of Patient-Derived Breast Cancer Xenografts
In this work, researchers analyzed the genomic and gene expression profiles of human breast cancer xenografts and the corresponding patient tumors. [Breast Cancer Res] Abstract

Membrane Estrogen Signaling Enhances Tumorigenesis and Metastatic Potential of Breast Cancer Cells via Estrogen Receptor-α36 (ERα36)
Researchers’ findings propose ERα36 as a novel target for the development of therapies that can prevent progression of breast cancer in the primary tumor as well as during metastasis. [J Biol Chem] Abstract

HGF-Induced PKCζ Activation Increases Functional CXCR4 Expression in Human Breast Cancer Cells
In this study, researchers found that hepatocyte growth factor (HGF) induced functional CXCR4 receptor expression in breast cancer cells, and the effect of HGF was specifically mediated by PKCζ activity. [PLoS One] Abstract

c-MET Protects Breast Cancer Cells from Apoptosis Induced by Sodium Butyrate
In this study, a specific breast cancer cell population that is resistant to sodium butyrate treatment was identified. [PLoS One] Abstract

Alterations in c-Src/HER1 and Estrogen Receptor α Signaling Pathways in Mammary Gland and Tumors of Hexachlorobenzene-Treated Rats
In the present study, researchers examined hexachlorobenzenes effect on c-Src/human epidermal growth factor receptor (HER1) and estrogen receptor α signaling pathways in mammary glands and in N-nitroso-N-methylurea-induced mammary tumors in rats. [Toxicology] Abstract

CLINICAL RESEARCH

Null Alleles of ABCG2 Encoding the Breast Cancer Resistance Protein Define the New Blood Group System Junior
Researchers report here that ABCG2 comprises the molecular basis of a new blood group system (Junior, Jr) and that individuals of the Jr(a−) blood type have inherited two null alleles of ABCG2. [Nat Genet] Abstract

Lapatinib versus Trastuzumab in Combination with Neoadjuvant Anthracycline-Taxane-Based Chemotherapy (GeparQuinto, GBG 44): A Randomized Phase III Trial
Researchers compared the efficacy and safety of the addition of lapatinib versus trastuzumab to anthracycline-taxane-based neoadjuvant chemotherapy. [Lancet] Abstract | Press Release

CIRM Allocates $40 Million to Support Stem Cell Genomics, Speeding Development of Therapies for Patients
California stem cell scientists will have a new resource for advancing therapies with a $40 million initiative approved by the governing board of the California Institute for Regenerative Medicine (CIRM). [California Institute for Regenerative Medicine] Press Release

SonoCiné Automated Whole Breast Cancer Screening System Receives Approval from Health Canada
SonoCiné, Inc. announced that it has been granted a Class 2 Medical Device License by the Medical Devices Bureau of Health Canada to sell and market its Automated Whole Breast Acquisition Screening System as an adjunct to mammography for screening asymptomatic women for breast cancer. [SonoCiné, Inc.]
Press Release

Damon Runyon Grants Fellowship and Breakthrough Scientist Awards to 21 Top Young Scientists
The Damon Runyon Cancer Research Foundation named 18 new Damon Runyon Fellows at its fall Fellowship Award Committee review. [Damon Runyon Cancer Research Foundation] Press Release

NEW 6^th Inter-American Breast Cancer Conference
July 25-28, 2012
Cancun, Mexico

NEW 8^th European Breast Cancer Conference
March 21-24, 2012
Vienna, Austria

Visit our events page to see a complete list of events in the mammary cell community.

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Fellow (University of Alberta)

Postdoctoral Positions (Cancer Science Institute of Singapore)

Research Postdoctoral Fellow (Institut Curie UMR 144)

Postdoctoral Fellow and Technician Positions (North Carolina Central University)

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