Mammary Cell News Volume 4.10 | Mar 15 2012

Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers
In this study researchers used system-wide analysis of breast cancer proteomes to identify proteins that are associated with the progression of estrogen receptor negative tumors. [Cancer Res] Abstract

Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma
In this study, scientists investigated epidermal growth factor receptor vIII expression and amplification in primary breast carcinoma. [Cancer Res] Abstract

N-Cadherin Regulates Mammary Tumor Cell Migration through Akt3 Suppression
Here, researchers show that in vivo expression of N-cadherin in the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylation. [Oncogene] Abstract

Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy
The simultaneous blockade of both PI3K/Akt/mTOR and ERK pathways obtained by combining lapatinib with INK-128 acts synergistically in inducing cell death and tumor regression in breast cancer models refractory to anti-HER2 therapy. [Clin Cancer Res] Abstract

Potential of PET to Predict the Response to Trastuzumab Treatment in an ErbB2-Positive Human Xenograft Tumor Model
Scientists studied the feasibility of using PET to quantify changes in ErbB2 expression and to predict the response to trastuzumab in BT474 breast cancer xenografts with N-[2-(4-¹⁸F-fluorobenzamido)ethyl]maleimide (¹⁸F-FBEM)-HER_2:342 Affibody. [J Nucl Med] Abstract

The Synthetic Triterpenoid CDDO-Methyl Ester Delays Estrogen Receptor-Negative Mammary Carcinogenesis in Polyoma Middle T Mice
Researchers tested activity of the methyl ester derivative of the synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me), in a relevant model of ER-negative breast cancer, the polyoma-middle T, in which the oncoprotein drives carcinogenesis. [Cancer Prev Res] Abstract

Cadherin-23 Mediates Heterotypic Cell-Cell Adhesion Between Breast Cancer Epithelial Cells and Fibroblasts
Here investigators show that MCF-7 breast cancer epithelial cells and normal breast fibroblasts form heterotypic adhesions when grown together in co-culture, as evidenced by adhesion assays. [PLoS One] Abstract | Press Release

CLINICAL RESEARCH

Sorafenib in Combination with Capecitabine: An Oral Regimen for Patients with HER2-Negative Locally Advanced or Metastatic Breast Cancer
A randomized, double-blind, placebo-controlled phase IIB trial assessed sorafenib with capecitabine for locally advanced or metastatic human epidermal growth factor receptor 2-negative breast cancer. [J Clin Oncol] Abstract

Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer: A Population-Based Prospective Cohort Study
Researchers examined the association between dietary cadmium exposure (at baseline, 1987) and the risk of overall and estrogen receptor (ER)–defined (ER⁺ or ER⁻) breast cancer within a population-based prospective cohort of 55,987 postmenopausal women. [Cancer Res] Abstract | Press Release

ICGC Launches New Project and Releases More Genomic Data on Cancer
The International Cancer Genome Consortium (ICGC) announced a new project from South Korea to identify the genomic drivers in breast cancer, which will improve understanding and clinical management of this disease. ICGC also announced its eighth major data release. [Canada Newswire] Press Release

Visit our events page to see a complete list of events in the mammary cell community.

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Tenure Track Position (Johns Hopkins University)

Research Associate (Imperial College London)

Postdoctoral Fellow, Cancer Biology (North Carolina Central University)

Postdoctoral Fellow and Technician Positions (North Carolina Central University)

Postdoctoral Research Scientist (The Beatson Institute for Cancer Research) 


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