LABORATORY RESEARCH Tumor Initiating but Differentiated Luminal-Like Breast Cancer Cells Are Highly Invasive in the Absence of Basal-Like Activity Researchers demonstrate that basal-like cells are not a requirement for breast tumor aggressiveness, and that within a single tumor there are multiple “stem-like” cells with tumorigenic potential casting some doubt on the hypothesis of hierarchical or differentiative loss of tumorigenicity. [Proc Natl Acad Sci USA] Abstract Dithiolethiones Inhibit NF-κB Activity via Covalent Modification in Human Estrogen Receptor-Negative Breast Cancer Scientists investigated the chemical and biochemical effects of dithiolethione on NF-κB and downstream effector molecules in estrogen receptor negative breast cancer cells and murine tumor xenografts. [Cancer Res] Abstract Growth Hormone Receptor Blockade Inhibits Growth Hormone-Induced Chemoresistance by Restoring Cytotoxic-Induced Apoptosis in Breast Cancer Cells Independently of Estrogen Receptor Expression Researchers aim was to evaluate whether growth hormone (GH) may impact chemoresistance phenotype of estrogen receptor (ER)-negative breast cancer (BC)-derived MDA-MB-231 cell line and investigate the possible mechanisms implicated in the protective action of GH toward the cytotoxic effects of doxorubicin in both ER-positive and ER-negative BC-derived cell lines. [J Clin Endocrinol Metab] Abstract Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27 Researchers suggest that Yin Yang 1 (YY1) is an oncogene and identify p27 as a new target of YY1. [Am J Pathol] Abstract Estrogen Regulates JNK1 Genomic Localization to Control Gene Expression and Cell Growth in Breast Cancer Cells Researchers demonstrate a functional convergence of the estrogen and c-Jun N-terminal kinase 1 (JNK1) signaling pathways at the genomic level in breast cancer cells. [Mol Endocrinol] Abstract MiR-21 Regulates EMT Phenotype and HIF-1α Expression in Third-Sphereforming Breast Cancer Stem Cell-Like Cells Third-sphereforming cancer stem cell (CSC)-like cells, which showed elevated CSC surface markers and sphereforming capacity as well as migration and invasion capacities, were cultured and isolated from breast cancer MCF-7 parental cells, to evaluate the role of miR-21 in regulating the CSC-like cell biological features, especially epithelial-mesenchymal transition (EMT). [Cancer Sci] Abstract Downregulation of HuR as a New Mechanism of Doxorubicin Resistance in Breast Cancer Cells Researchers investigated the role of HuR in the apoptosis and in the chemoresistance induced by the widely used anticancer drug doxorubicin in human breast cancer cells. [Mol Cancer] Abstract Overexpression of Forkhead Box J2 Can Decrease the Migration of Breast Cancer Cells Scientists demonstrate that Forkhead Box J2 can inhibit the metastasis of human breast cancer by regulating the EMT key markers E-cadherin and vimentin. [J Cell Biochem] Abstract CLINICAL RESEARCH Limited Value and Utility of Breast MRI in Patients Undergoing Breast-Conserving Cancer Surgery Researchers compare the accuracy of magnetic resonance imaging (MRI) and ultrasonography (US) in measuring the size of invasive breast cancer and carcinoma in situ. They also examine the utility of routinely performing MRI in addition to US before breast-conserving surgery. [Ann Surg Oncol] Abstract The Association between Breast Cancer Prognostic Indicators and Serum 25-OH Vitamin D Levels Scientists examine 25-OH vitamin D levels between breast cancer (BC) cases and controls and by prognostic indicators among BC cases. [Ann Surg Oncol] Abstract |