LABORATORY RESEARCH Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer Scientists show that the RKIP/EZH2 ratio significantly decreases with the severity of disease and is negatively associated with relapse-free survival in breast cancer. [Cancer Res] Abstract Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Researchers analyzed paired-end mRNA-Seq data from a panel of estrogen receptor-positive, HER2+, and triple-negative primary breast tumors. [Cancer Res] Abstract | Press Release Re-Expression of MicroRNA-375 Reverses Both Tamoxifen Resistance and Accompanying EMT-Like Properties in Breast Cancer To investigate the role of microRNAs in the development of resistance to tamoxifen as well as accompanying epithelial-mesenchymal transition (EMT)-like properties, researchers established a tamoxifen-resistant model by continually exposing MCF-7 breast cancer cells to tamoxifen. [Oncogene] Abstract Specific β-Containing Integrins Exert Differential Control on Proliferation and Two-Dimensional Collective Cell Migration in Mammary Epithelial Cells Researchers described the consequences of removing the β1-integrin gene from primary cultures of mammary epithelial cells in situ, using CreER. [J Biol Chem] Abstract X-Linked Inhibitor of Apoptosis Protein Inhibition and Generation of Reactive Oxygen Species Enhances TRAIL Sensitivity in Inflammatory Breast Cancer Cells Researchers evaluated the effect of classical apoptosis inducing agent TRAIL in an inflammatory breast cancer acquired resistance model. [Mol Cancer Ther] Abstract BRCA1-IRIS Overexpression Promotes Formation of Aggressive Breast Cancers Investigators examined whether BRCA1-IRIS is a valuable treatment target for HER2+ and/or triple negative/basal-like tumors. [PLoS One] Abstract Human Amniotic Fluid-Derived Stem Cells Expressing Cytosine Deaminase and Thymidine Kinase Inhibits the Growth of Breast Cancer Cells in Cellular and Xenograft Mouse Models Researchers used human amniotic fluid-derived stem cells as vehicles for targeted delivery of therapeutic suicide genes to breast cancer cells. [Cancer Gene Ther] Abstract Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis Scientists tested whether Polo-like kinase 1 (PLK1) small interfering RNAs (siRNAs) complexed with a Her2-single-chain fragmented antibody (ScFv)-protamine peptide fusion protein could suppress Her2+ breast cancer cell lines and primary human cancers in orthotopic breast cancer models. [Sci Transl Med] Abstract | Press Release CLINICAL RESEARCH Analysis of Fcγ Receptor IIIa and IIa Polymorphisms: Lack of Correlation with Outcome in Trastuzumab-Treated Breast Cancer Patients Scientists determined whether high affinity single nucleotide polymorphisms are associated with disease free survival among patients with HER2-positive non-metastatic breast cancer. [Clin Cancer Res] Abstract Breast Cancer Incidence in Postmenopausal Women with Osteoporosis or Low Bone Mass Using Arzoxifene Investigators report breast cancer findings from the Generations trial, a multicenter, placebo-controlled, double-blind trial, that compared arzoxifene 20 mg/day and placebo in 9,354 postmenopausal women with osteoporosis or low bone mass. [Breast Cancer Res Treat] Abstract |