LABORATORY RESEARCH A Metabolic Pro-Survival Role for PML in Breast Cancer Researchers identified a metabolic function for the promyelocytic leukemia (PML) gene, uncovering an unexpected role for this bona fide tumor suppressor in breast cancer cell survival. [J Clin Invest] Full Article Dynamically Varying Interactions between Heregulin and ErbB Proteins Detected by Single-Molecule Analysis in Living Cells Scientists observed the reaction kinetics between fluorescently labeled single heregulin molecules and ErbB3/B4 on the surfaces of MCF-7 human breast cancer cells. [Proc Natl Acad Sci USA] Abstract The Hippo Pathway Target, YAP, Promotes Metastasis through Its TEAD-Interaction Domain Researchers demonstrated that, in addition to increasing tumor growth, increased yes-associated protein (YAP) activity is potently prometastatic in breast cancer and melanoma cells. They also showed that, through its TEAD-interaction domain, YAP enhances multiple processes known to be important for tumor progression and metastasis. [Proc Natl Acad Sci USA] Abstract | Full Article Gankyrin Promotes Breast Cancer Cell Metastasis by Regulating Rac1 Activity Investigators found that knocking down Gankyrin expression in highly metastatic human breast cancer cells significantly decreases cancer cell migration and invasion. [Oncogene] Abstract BCAR4 Induces Anti-Estrogen Resistance but Sensitizes Breast Cancer to Lapatinib Researchers determined whether BCAR4 expression sensitizes breast cancer cells to lapatinib and identified a subgroup of patients who may benefit from ERBB2-targeted therapies despite having tumors with low ERBB2 expression. [Br J Cancer] Abstract Induction of Endoplasmic Reticulum Stress Response by the Indole-3-Carbinol Cyclic Tetrameric Derivative CTet in Human Breast Cancer Cell Lines Researchers have previously shown that the indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits cell proliferation via inhibition of Akt activity and overexpression of p21/CDKN1A and GADD45A, in both estrogen receptor-positive and triple negative breast cancer cell lines. Here, they further characterized the autophagic response and investigated the mechanism through which CTet regulates these events. [PLoS One] Full Article Role of KCNMA1 in Breast Cancer Findings revealed that enhanced expression of KCNMA1 correlates with and contributes to high proliferation rate and malignancy of breast cancer. [PLoS One] Full Article Interferon Regulatory Factor 4 Binding Protein Is a Novel p53 Target Gene and Suppresses Cisplatin-Induced Apoptosis of Breast Cancer Cells Results demonstrated that interferon regulatory factor 4 binding protein (IBP) is a novel p53 target gene that suppresses cisplatin-mediated apoptosis of breast cancer cells via negative feedback regulation of the p53 signaling pathway, suggesting that IBP may serve as a target for pharmacologic intervention of breast cancer resistant to cisplatin therapy. [Mol Cancer] Abstract | Full Article CLINICAL RESEARCH Subcutaneous versus Intravenous Administration of (Neo)Adjuvant Trastuzumab in Patients with HER2-Positive, Clinical Stage I-III Breast Cancer: A Phase III, Open-Label, Multicentre, Randomized Trial Scientists compared the pharmacokinetic profile, efficacy, and safety of subcutaneous and intravenous formulations in patients with HER2-positive early breast cancer. [Lancet Oncol] Abstract Bone-Related Complications and Quality of Life in Advanced Breast Cancer: Results from a Randomized Phase III Trial of Denosumab versus Zoledronic Acid Investigators found that denosumab was superior to zoledronic acid in reducing bone-related complications of metastatic breast cancer and maintained health-related quality of life, providing an efficacious, well-tolerated treatment option for patients with bone metastases from breast cancer. [Clin Cancer Res] Abstract | Press Release |