LABORATORY RESEARCH Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer Researchers identified Debio-0719 as a drug candidate with metastasis suppressor activity, inducing dormancy at secondary tumor sites. [J Natl Cancer Inst] Abstract FAM83B Mediates EGFR- and RAS-Driven Oncogenic Transformation Ablation of family with sequence similarity 83, member B (FAM83B) inhibited the proliferation and malignant phenotype of tumor-derived cells or RAS-transformed human mammary epithelial cells, implicating FAM83B as a key intermediary in EGFR/RAS/MAPK signaling. [J Clin Invest] Full Article | Press Release An Integrated Transcriptional Regulatory Circuit that Reinforces the Breast Cancer Stem Cell State Using a genetic screen in an inducible model of cancer stem-like cell (CSC) formation in a breast cell line, researchers identified microRNAs that inhibit CSC growth and are down-regulated in CSCs. [Proc Natl Acad Sci USA] Abstract MLK3 Regulates Paxillin Phosphorylation in Chemokine-Mediated Breast Cancer Cell Migration and Invasion to Drive Metastasis Researchers provide evidence that MLK3 is required for chemokine-induced invasion of basal breast cancer cells. [Cancer Res] Abstract Decreased eIF3e/Int6 Expression Causes Epithelial-to-Mesenchymal Transition in Breast Epithelial Cells To gain a better understanding of the role of eIF3e/Int6 in breast cancer, investigators examined the effects of decreased eIF3e/Int6 expression in an immortalized breast epithelial cell line. [Oncogene] Abstract Tamoxifen Regulates Cell Fate through Mitochondrial Estrogen Receptor Beta in Breast Cancer Researchers found that tamoxifen engaged mitochondrial estrogen receptor beta as an antagonist in MCF7-BK cells, increasing reactive oxygen species concentrations from the mitochondria that were required for cytotoxicity. [Oncogene] Abstract Oncolytic Vaccinia Virus GLV-1h68 Strain Shows Enhanced Replication in Human Breast Cancer Stem-Like Cells in Comparison to Breast Cancer Cells Investigators aimed to demonstrate whether the oncolytic vaccinia virus kills cancer stem cells that are resistant to irradiation and chemotherapy. [J Transl Med] Abstract | Full Article Treatment of Breast Cancer Stem Cells with Oncolytic Herpes Simplex Virus Scientists demonstrated that oncolytic herpes simplex viruses (oHSVs) are effective against breast cancer stem cells and suggested that oHSVs could be a beneficial strategy for treating breast cancer patients. [Cancer Gene Ther] Full Article CLINICAL RESEARCH Relationship between Mammographic Density and Breast Cancer Death in the Breast Cancer Surveillance Consortium Scientists found that high mammographic breast density was not associated with risk of death from breast cancer or death from any cause after accounting for other patient and tumor characteristics. [J Natl Cancer Inst] Abstract | Press Release | Related Interview Soluble KIT Correlates with Clinical Outcome in Patients with Metastatic Breast Cancer Treated with Sunitinib The ability of soluble KIT, vascular endothelial growth factor-A (VEGF-A), soluble VEGF receptor-2 (sVEGFR-2), and sVEGFR-3 to predict clinical outcome was analyzed in 61 patients with previously treated metastatic breast cancer in a phase II study of sunitinib monotherapy. [J Transl Med] Abstract | Full Article PPAR Signaling Pathway May Be an Important Predictor of Breast Cancer Response to Neoadjuvant Chemotherapy To predict the responses to chemotherapy, researchers performed a phase II trial of neoadjuvant chemotherapy using a weekly paclitaxel plus carboplatin regimen for stage II/III breast cancer and assessed the correlation between baseline gene expression and the tumor response to treatment. [Cancer Chemother Pharmacol] Abstract |