Reversal by RARα Agonist Am580 of c-Myc-Induced Imbalance in RARα/RARγ Expression during MMTV-Myc Tumorigenesis The effects of c-Myc on retinoic acid receptor (RAR) isotype expression were evaluated in normal mouse mammary epithelium, mammary tumor cells obtained from the mouse mammary tumor virus (MMTV)-Myc transgenic mouse model as well human normal immortalized breast epithelial and breast cancer cell lines. The in vivo effect of the RARα-selective agonist Am580 was examined in the MMTV-Myc mouse model of mammary tumorigenesis. [Breast Cancer Res] Abstract |Full Article
The Interaction between ER and NFκB in Resistance to Endocrine Therapy Authors provide an overview of the mechanisms of action of both transcription factors and focus on the current knowledge explaining how estrogen receptor (ER) and NFκB affect each other’s activity and how this cross-talk might contribute to the development of an endocrine resistance phenotype in breast cancer cells. [Breast Cancer Res] Abstract |Full Article
Researchers Receive Grants from NCCN Oncology Research Program Funded through Boehringer Ingelheim The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program awarded five research grants. These grants were made possible through a $2 million research grant from Boehringer Ingelheim Pharmaceuticals, Inc. to scientifically evaluate and define the clinical effectiveness of afatinib in solid tumors, including breast cancers. [National Comprehensive Cancer Network] Press Release
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