LABORATORY RESEARCH A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis The authors report the development of a mouse model of spontaneous breast cancer metastasis which recapitulates key events in its formation and clinical course. [Cancer Res] Abstract Tumor Associated Macrophages Regulate Murine Breast Cancer Stem Cells through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway Scientists report that tumor-associated macrophages promote cancer stem cell-like phenotypes in murine breast cancer cells by upregulating their expression of Sox-2. [Stem Cells] Abstract Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms The authors investigated the role of interleukin-8 in the regulation of cancer stem-like cells activity using patient-derived breast cancers and determined the potential benefit of combining CXCR1/2 inhibition with HER2-targeted therapy. [Clin Cancer Res] Abstract CLOCK Is a Substrate of SUMO and Sumoylation of CLOCK Upregulates the Transcriptional Activity of Estrogen Receptor-α Scientists showed that circadian locomotor output cycles kaput (CLOCK), a key circadian protein, can interact with estrogen receptor-α. Furthermore, this interaction was enhanced by estrogen. [Oncogene] Abstract Class IIa HDACs Repressive Activities on MEF2-Dependent Transcription Are Associated with Poor Prognosis of ER+ Breast Tumors The authors found that class IIa HDACs are heterogeneously expressed and display redundant activities in breast cancer cells. [FASEB J] Abstract TCPTP Regulates Src Family Protein Tyrosine Kinases and STAT3 Signaling and Is Lost in Triple Negative Breast Cancers Scientists report that TCPTP protein levels are decreased in a subset of breast cancer cell lines in vitro and that TCPTP protein is absent in a large proportion of ‘triple negative’ primary human breast cancers. [Mol Cell Biol] Abstract Loss of Pigment Epithelium-Derived Factor: A Novel Mechanism for the Development of Endocrine Resistance in Breast Cancer The authors investigated the role of pigment epithelium-derived factor in the development of endocrine resistance in breast cancer. [Breast Cancer Res] Abstract | Full Article Heparins Modulate the IFN-γ-Induced Production of Chemokines in Human Breast Cancer Cells Researchers tested whether heparins had an impact on the chemokines CXCL9 and CXCL10 as well as the IFN-γ signaling in human breast cancer cells in vitro. [Breast Cancer Res Treat] Abstract CLINICAL RESEARCH Risk of Metachronous Breast Cancer after BRCA Mutation-Associated Ovarian Cancer The authors sought to estimate the risk of breast cancer after a diagnosis of ovarian cancer associated with mutation of the BRCA1/2 (breast cancer, early onset) genes. [Cancer] Abstract The Risk of Primary and Contralateral Breast Cancer after Ovarian Cancer in BRCA1/BRCA2 Mutation Carriers The objective of this study was to assess the incidence of primary breast cancer and contralateral breast cancer in patients who had BRCA1/BRCA2-associated epithelial ovarian cancer. [Cancer] Abstract |