Mammary Cell News Volume 5.05 | Feb 7 2013

    0
    53

    Mammary Cell News 5.05 February 7, 2013
    Mammary Cell News
         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
    Cell Therapy News on Facebook  Mammary Cell News on Twitter

    TOP STORY
    APOBEC3B Is an Enzymatic Source of Mutation in Breast Cancer
    Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at hydrolytically disfavored non-methylated cytosines throughout the genome, and are sometimes clustered. Scientists showed that the DNA cytosine deaminase APOBEC3B is a probable source of these mutations. [Nature] Abstract | Press Release

    Free Interactive Tutorial: Explore Mammary Progenitor Cell Colonies

    PUBLICATIONS (Ranked by impact factor of the journal)

    LABORATORY RESEARCH

    Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
    Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis in preclinical models. To investigate its role in human cancer, scientists characterized EMT in circulating tumor cells from breast cancer patients. [Science] Abstract | Press Release

    Preclinical Therapy of Disseminated HER-2+ Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus
    Investigators retargeted herpes simplex virus tropism to HER-2 oncoprotein p185, overexpressed in ovary and breast cancers. The HER-2-retargeted R-LM249 exclusively infects and kills tumor cells expressing high levels of human HER-2. [PLoS Pathol] Full Article

    MicroRNA-7 Suppresses Brain Metastasis of Breast Cancer Stem-Like Cells by Modulating KLF4
    Cancer stem-like cells (CSCs) are considered to play a role in metastatic progression of breast cancer; however, the exact pathologic role of CSCs is yet to be elucidated. Researchers found that CSCs (CD24/CD44+/ESA+) isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ-specific manner. [Cancer Res] Abstract | Press Release

    FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer
    Scientists report that the transcription factor FOXC2 induced in response to multiple epithelial-mesenchymal transition (EMT) signaling pathways as well as elevated in stem cell-enriched factions is a critical determinant of mesenchymal and stem cell properties, in cells induced to undergo EMT and cancer stem cell-enriched breast cancer cell lines. [Cancer Res] Abstract

    Ink4a/Arf−/− and HRAS(G12V) Transform Mouse Mammary Cells into Triple-Negative Breast Cancer Containing Tumorigenic CD49f Quiescent Cells
    Investigators proposed to engineer a mouse mammary tumor model with intratumoral heterogeneity by using defined genetic perturbations. To achieve this, they used mice with knockout (-/-) of Ink4a/Arf, a tumor suppressor locus; these mice are known to be susceptible to non-mammary tumors such as fibrosarcoma. [Oncogene] Abstract

    Microfabricated Collagen Tracks Facilitate Single Cell Metastatic Invasion in 3D
    Studies have shown that some cancer cells can use proteolysis to mechanically rearrange their extracellular matrix to form tube-like “microtracks” which other cells can follow without using matrix metalloproteinases themselves. The authors speculate that this mode of migration in the secondary cells may be one example of migration which can occur without endogenous protease activity in the secondary cells. They present a technique to study this migration in a 3D, collagen-based environment which mimics the size and topography of the tracks produced by proteolytically active cancer cells. [Integrative Biol] Abstract

    The HER2- and Heregulin β1 (HRG)-Inducible TNFR Superfamily Member Fn14 Promotes HRG-Driven Cell Migration, Invasion and Matrix Metalloproteinase-9 Expression
    In a previous study, the authors found that fibroblast growth factor-inducible 14 (Fn14), a member of the TNF receptor (TNFR) superfamily, was frequently overexpressed in human epidermal growth factor receptor-2 (HER2)+ breast tumors. They report here that HER2 and Fn14 are also co-expressed in mammary tumors that develop in two different transgenic mouse models of breast cancer. [Mol Cancer Res] Abstract

    Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells
    The authors report on the relationship between nuclear receptors activity and the modulation of the pro-inflammatory phenotype in breast cancer stem cells. [PLoS One] Full Article

    CLINICAL RESEARCH

    Phase II Randomized Study of Trastuzumab Emtansine versus Trastuzumab Plus Docetaxel in Patients with Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer
    Patients with human epidermal growth factor receptor 2-positive metastatic breast cancer or recurrent locally advanced breast cancer were randomly assigned to trastuzumab plus docetaxel or trastuzumab emtansine as first-line treatment until disease progression or unacceptable toxicity. [J Clin Oncol] Abstract

    Multicenter Phase II Trial of Bevacizumab Combined with Docetaxel-Carboplatin for the Neoadjuvant Treatment of Triple-Negative Breast Cancer (KCSG BR-0905)
    Women with hormone receptor- and human epidermal growth factor receptor 2-negative, stage II/III breast cancer received six cycles of docetaxel, carboplatin and bevacizumab every 21 days. [Ann Oncol] Abstract

    FREE ALDEFLUOR™ Protocol Optimization Resource Pack – Get Yours

    REVIEWS
    CCL5 as a Potential Immunotherapeutic Target in Triple-Negative Breast Cancer
    The authors review the clinical and laboratory work that has led to their own hypothesis that targeting CCL5 in triple-negative breast cancer will have favorable therapeutic outcomes with minimal adverse impact on the general physiology. [Cell Mol Immunol] Abstract

    INDUSTRY NEWS

    Aduro Announces Acquisition of GVAX Assets from BioSante
    Aduro BioTech, Inc. announced the acquisition of all GVAX assets from BioSante Pharmaceuticals, Inc., including intellectual property and cell lines. Aduro previously licensed two GVAX vaccines, GVAX Pancreas and GVAX Prostate, for use in combination with its Listeria-based vaccines. This new acquisition covers all uses and includes additional vaccines for multiple myeloma and breast and colon cancer and assumes rights to the existing license agreement for GVAX Melanoma. [Business Wire] Press Release

    Oasmia Signs Marketing and Distribution Agreement for Product Candidate Paclical® in Russia and CIS Countries
    Oasmia Pharmaceutical and Pharmasyntez have entered into an exclusive marketing and distribution agreement concerning Oasmia’s product candidate Paclical, for the treatment of ovarian cancer, lung cancer and second line breast cancer. [Oasmia Pharmaceutical AB] Press Release

    POLICY NEWS

    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

    EVENTS
    NEW Keystone Symposium: The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer
    May 19-23, 2013
    Monterey, United States

    Visit
    our events page to see a complete list of events in the mammary cell community.

    JOB OPPORTUNITIES

    Postdoctoral Position – Gene Regulation in Breast Cancer/Stem Cell Biology (UC College of Medicine)

    Postdoctoral Position – Impact of Ubiquitin-Proteasome Pathway in Genome Stability and Breast Cancer (University of Pittsburgh)

    Postdoctoral Position – Bioinformatics Position in Cancer Research (San Raffaele Scientific Institute)

    Postdoctoral Position – Regulation of Gene Expression in Breast Cancer (University of Cincinnati)

    Postdoctoral Research Assistant – Breast Cancer Campaign (University of Oxford)

    PhD Student – Breast Cancer Biology (IDIBELL, Catalan Institute of Oncology)

    Postdoctoral Position – Cancer Biology and Functional Genomics (North Carolina Central University)

    Postdoctoral Position – Stem Cell Biology (Ludwig Institute for Cancer Research)

    Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

    Have we missed an important article or publication in Mammary Cell News? Click here to submit!

    Comments or Suggestions? Email info@connexoncreative.com with your feedback.

    Learn more about Mammary Cell News: Archives | Events | Contact Us