| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Functional Cooperation of miR-125a, miR-125b, and miR-205 in Entinostat-Induced Downregulation of erbB2/erbB3 and Apoptosis in Breast Cancer Cells Researchers demonstrated that entinostat specifically induces expression of microRNA (miR)-125a, miR-125b, and miR-205, which act in concert to downregulate erbB2/erbB3 in breast cancer cells. [Cell Death Dis] Full Article Nox4-Dependent Reactive Oxygen Species Modulation by Amino Endoperoxides to Induce Apoptosis in Cancer Cells The authors describe a one-pot strategy to synthesize novel amino endoperoxides and their derivatives with good yields and stabilities. In vitro cell-based assays revealed that four out of the 14 amino endoperoxides selectively induce metastatic breast carcinoma cells but not normal breast cells to undergo apoptosis, in a dose-dependent manner. [Cell Death Dis] Full Article EpCAM Expression Varies Significantly and Is Differentially Associated with Prognosis in the Luminal B HER2+, Basal-Like, and HER2 Intrinsic Subtypes of Breast Cancer To investigate the association between epithelial cell adhesion molecule (EpCAM) expression and prognosis in the intrinsic subtypes of breast cancer, the authors performed immunohistochemical studies on a tissue microarray encompassing a total of 1365 breast cancers with detailed clinicopathological annotation and outcomes data. [Br J Cancer] Abstract KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells Researchers report that either kisspeptin-10 treatment of estrogen receptor (ER)α-negative non-malignant mammary epithelial MCF10A cells or expression of KISS1R in MCF10A cells induced a mesenchymal phenotype and stimulated invasiveness. Similarly, exogenous expression of KISS1R in ERα-negative SKBR3 breast cancer cells was sufficient to trigger invasion and induced extravasation in vivo. [Endocrinology] Abstract Syndecan Binding Protein (SDCBP) Is Overexpressed in Estrogen Receptor Negative Breast Cancers, and Is a Potential Promoter for Tumor Proliferation SDCBP, an adapter protein containing PDZ domains, contributes to the tumorigenicity and metastasis of many malignant tumors, such as malignant melanoma. Scientists examined the expression profile of SDCBP in breast cancer (BCa) and its role in tumor cell proliferation, and then exploring its value in the targeted treatment of BCa. [PLoS One] Full Article BRG1 Is a Prognostic Marker and Potential Therapeutic Target in Human Breast Cancer Researchers explored the role of BRG1 in human breast cancer pathogenesis. Using tissue microarray and immunohistochemistry, they evaluated BRG1 staining in 437 breast cancer specimens and investigated its role in breast cancer cell proliferation, migration and invasion. [PLoS One] Full Article Targeting Heat Shock Proteins by Phenethyl Isothiocyanate Results in Cell-Cycle Arrest and Apoptosis of Human Breast Cancer Cells Researchers aimed to determine the effect of natural isothiocyanate (phenethyl isothiocyanate) on different heat shock proteins and heat shock factor 1 in two breast cancer cell lines, namely breast adenocarcinoma MCF-7 (with wild type p53) and highly metastatic breast cancer cell MDA-MB-231 (with mutated p53). [Nutr Cancer] Abstract CLINICAL RESEARCH Large-Scale Genotyping Identifies 41 New Loci Associated with Breast Cancer Risk The authors report a meta-analysis of nine genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which they selected 29,807 SNPs for further genotyping. They identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance. [Nat Genet] Abstract | Press Release Enrichment of Regulatory T Cells in Invasive Breast Tumor Correlates with the Upregulation of IL-17A Expression and Invasiveness of the Tumor Researchers found that regulatory T (Treg) and Th17 cells can affect disease progression by Treg-cell-mediated suppression of the effector T-cell response, as indicated by a decrease in the proliferation of T cells isolated from PBMCs of invasive ductal carcinoma of the breast patients and induction of angiogenic factors by IL-17-producing Th17. [Eur J Immunol] Abstract Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) as a Prognostic Marker for Local Control in T1-2 N0 Breast Cancer Treated with Breast-Conserving Surgery and Radiation Therapy (BCS + RT) Researchers evaluated the prognostic significance of IFIT1 protein expression in patients with breast cancer treated with BCS + RT. A tissue microarray was constructed with specimens from 282 women with node-negative, early-stage (I/II) breast cancer who were treated with BCS + RT. Immunohistochemistry was used to stain for the IFIT1 protein. [Breast J] Abstract |
| REVIEWS | The Role of Intratumoral and Systemic IL-6 in Breast Cancer The authors review the associations between IL-6 and breast cancer ranging from in vitro cell culture studies to clinical studies, covering the role of IL-6 in controlling breast cancer cell growth, regulation of cancer stem cell renewal, as well as breast cancer cell migration. [Breast Cancer Res Treat] Abstract A Bi-Faceted Role of Estrogen Receptor Beta in Breast Cancer In clinical studies and most often in cell culture studies, the pro-growth and pro-survival activity of estrogen receptor (ER) beta occurs in ER alpha negative breast cancer tissue and cells. This bi-faceted role of ER beta is reviewed. [Endocr Relat Cancer] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. |
| INDUSTRY NEWS | Varian Medical Systems Highlights Calypso® System and Other Technologies Designed to Help Reduce the Risk of Heart Disease after Radiotherapy for Breast Cancer Varian Medical Systems is highlighting its Calypso® System as a tool designed to help doctors reduce women’s risk of developing heart disease years after treatment for breast cancer. The system uses GPS for the Body® technology to help minimize exposure of the heart during treatment for breast cancer. [Varian Medical Systems] Press Release Susan G. Komen for the Cure® Announces New Grants and Partnership with the National Football League Players Association to Kick Off the 2013 Global Race for the Cure Susan G. Komen for the Cure®, the world’s leading breast cancer organization, announced $1.5 million in new D.C.-area community health grants at an event that also marked the kickoff of a new partnership with the NFL Players’ Association. [Susan G. Komen] Press Release Hologic’s “3D Technology: A More Accurate Mammogram” Mobile Coach Tour Makes Special Stop at National Consortium of Breast Center’s Annual Conference in Las Vegas Hologic, Inc. brought its “3D Technology: A More Accurate Mammogram ” mobile coach tour to the National Consortium of Breast Center’s (NCBC) 23rd Annual National Interdisciplinary Breast Center Conference in Las Vegas, Nevada. [Hologic, Inc.] Press Release AACR Elects Carlos L. Arteaga, M.D., as President-Elect 2013-2014 The members of the American Association for Cancer Research (AACR) have elected Carlos L. Arteaga, M.D., as their president-elect for 2013-2014. Arteaga is a professor of medicine and cancer biology at Vanderbilt University School of Medicine where he holds the Donna S. Hall chair in breast cancer research. He also serves as associate director for clinical research and director of the Breast Cancer Research Program at Vanderbilt-Ingram Cancer Center in Nashville, Tenn. [American Association for Cancer Research] Press Release |
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