LABORATORY RESEARCH IBP Regulates Epithelial-to-Mesenchymal Transition and the Motility of Breast Cancer Cells via Rac1, RhoA and Cdc42 Signaling Pathways Researchers found that increased expression of interferon regulatory factor 4 binding protein (IBP) was associated with the progression of breast cancer and that IBP levels were significantly elevated in matched distant metastases. [Oncogene] Full Article Pre-Irradiation of Mouse Mammary Gland Stimulates Cancer Cell Migration and Development of Lung Metastases Scientists demonstrated that pre-irradiation of the mammary gland increased by 1.8-fold the migration of cancer cells, by 2-fold the quantity of circulating cancer cells and by 2.4-fold the number of lung metastases. These adverse effects were shown to be associated with the induction of interleukin-6 and cyclooxygenase-2. [B J Cancer] Abstract Altered Glucose Metabolism in Harvey-ras Transformed MCF10A Cells Authors examined the effect Harvey-ras (H-ras) transformation on glucose metabolism using the untransformed MCF10A and H-ras oncogene transfected (MCF10A-ras) human breast epithelial cells, a model for early breast cancer progression. [Mol Carcinog] Abstract Identification of FDA-Approved Drugs Targeting Breast Cancer Stem Cells Along With Biomarkers of Sensitivity Gene expression datasets of Cancer Stem Cells (CSCs) from six studies were subjected to connectivity map to identify drugs that may ameliorate gene expression patterns unique to CSCs. [Sci Rep] Full Article Phospholipase D Inhibitor Enhances Radiosensitivity of Breast Cancer Cells Researchers evaluated the effects of phospholipase D (PLD) inhibition on cell survival, cell death and DNA damage after exposure to ionizing radiation (IR). Combined IR treatment and PLD inhibition led to an increase in the radiation-induced apoptosis of MDA-MB-231 metastatic breast cancer cells. [Exp Mol Med] Full Article CLINICAL RESEARCH Inverse Regulation of EGFR/HER1 and HER2-4 in Normal and Malignant Human Breast Tissue HER1-4 receptor and neuregulin-1 ligand mRNA expression levels in breast cancers and corresponding normal breast tissue from patients previously characterized for plasma and tissue estrogen levels were determined. [PLoS One] Full Article Luminal Breast Cancer Cell Lines Overexpressing ZNF703 Are Resistant to Tamoxifen Through Activation of Akt/mTOR Signaling Researchers found that high ZNF703 expression mainly occurred in estrogen receptor-positive and progesterone receptor-positive breast cancers. Furthermore, 4-hydroxytamoxifen had different modes of action in breast cancer cell lines with high or low ZNF703 expression. [PLoS One] Full Article Diagnostic and Therapeutic Strategy and the Most Efficient Prognostic Factors of Breast Malignant Fibrous Histiocytoma Scientists analyzed the clinicopathological features of nine breast malignant fibrous histiocytoma patients. Of the five cases expressing Ki-67, two of three patients with axillary lymph node involvement died between 6-8 months, and two died at 17 and 26 months after diagnosis. The two remaining cases, with low Ki-67 expression, had no recurrent or metastatic disease at 145 months after diagnosis. [Sci Reps] Full Article |