Mammary Cell News Volume 5.41 | Oct 17 2013

Sequential Application of a Cytotoxic Nanoparticle and a PI3K Inhibitor Enhances Antitumor Efficacy
Researchers engineered a supramolecular cis-platinum nanoparticle, which induced apoptosis in breast cancer cells but also elicited pro-survival signaling via an epidermal growth factor receptor-phosphatidylinositol 3 kinase (PI3K) pathway. [Cancer Res] Abstract

Silencing NOTCH Signaling Causes Growth Arrest in Both Breast Cancer Stem Cells and Breast Cancer Cells
Authors examined the mechanism of action of a small herbal molecule, psoralidin that has been shown to effectively suppress the growth of breast cancer stem cells and breast cancer cells, in breast cancer models. [Br J Cancer] Abstract

MiR-221/-222 Differentiate Prognostic Groups in Advanced Breast Cancers and Influence Cell Invasion
MicroRNA (MiR)-221/-222 expressions were analysed in 86 breast cancer tissues by quantitative RT-PCR and tested for correlation with immunohistochemistry data and clinical follow-up. In vitro assays were conducted using human breast cancer cell lines with lentiviral overexpression of miR-221/-222. [Br J Cancer] Abstract

Reduction of Tumor Angiogenesis Induced by Desmopressin in a Breast Cancer Model
Investigators explored the effects of desmopressin on tumor angiogenesis using the aggressive F3II mammary carcinoma in syngeneic Balb/c mice. [Breast Cancer Res Treat] Full Article

Aspirin-Induced Bcl-2 Translocation and Its Phosphorylation in the Nucleus Trigger Apoptosis in Breast Cancer Cells
Aspirin influenced the formation of a complex by B-cell lymphoma 2 (Bcl-2) and FK506-binding protein 38 and induced the nuclear translocation of Bcl-2 and its phosphorylation. These events inhibited cancer cell proliferation and subsequently enhanced MCF-7 breast cancer cell apoptosis. [Exp Mol Med] Full Article

CDK5 Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition and Breast Cancer Progression
Investigators found that cyclin-dependent kinase 5 (CDK5) participated in transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT). In MCF10A, TGF-β1 upregulated the CDK5 and p35 expression, and CDK5 knockdown inhibited TGF-β1-induced EMT. [Sci Rep] Full Article

CLINICAL RESEARCH

Randomized Trial of Preoperative Docetaxel with or without Capecitabine After Four Cycles of 5-Fluorouracil-Epirubicin-Cyclophosphamide (FEC) in Early-Stage Breast Cancer: Exploratory Analyses Identify Ki67 as a Predictive Biomarker for Response to Neoadjuvant Chemotherapy
Patients were randomized to four cycles of docetaxel/capecitabine or docetaxel alone after completion of four cycles of FEC. The primary endpoint was the pathological complete response rate. [Breast Cancer Res Treat]
Full Article

Treatment of Older Patients with HER2-Positive Metastatic Breast Cancer with Pertuzumab, Trastuzumab, and Docetaxel: Subgroup Analyses from a Randomized, Double-Blind, Placebo-Controlled Phase III Trial (CLEOPATRA)
Patients who had not received previous chemotherapy or biological therapy for HER2-positive locally recurrent, unresectable or metastatic breast cancer were randomly assigned to treatment with placebo, trastuzumab, and docetaxel or with pertuzumab, trastuzumab, and docetaxel. Primary endpoint was independently assessed progression-free survival. [Breast Cancer Res Treat] Full Article

Association of Positive EBAG9 Immunoreactivity with Unfavorable Prognosis in Breast Cancer Patients Treated with Tamoxifen
Researchers examined immunohistochemical staining of estrogen receptor-binding fragment associated antigen 9 (EBAG9) in 100 breast cancer specimens excised from patients at surgery before tamoxifen treatment. [Clin Breast Cancer] Abstract

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PARP Inhibitors May Hold Key to Better HER2-Positive Breast Cancer Treatment
Shih-Hsin Yang, M.D., Ph.D., the Regional Oncology Active Research Southeast Cancer Foundation Endowed Chair in the University of Alabama at Birmingham Department of Radiation Oncology, has received a $450,000 grant from Susan G. Komen for the Cure to further investigate human epidermal growth factor receptor 2 (HER2)-positive breast tumor susceptibility to poly ADP ribose polymerase (PARP) inhibitors. [The University of Alabama at Birmingham] Press Release

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