Mammary Cell News Volume 6.07 | Feb 27 2014

Estrogen Controls the Survival of BRCA1-Deficient Cells via a PI3K-NRF2-Regulated Pathway
Investigators showed that estrogen (E2) increases the expression of NRF2-dependent antioxidant genes in various E2-responsive cell types. [Proc Natl Acad Sci USA] Abstract

Estrogen Receptor Beta as a Novel Target of Androgen Receptor Action in Breast Cancer Cell Lines
Researchers demonstrated that mibolerone, a synthetic androgen ligand, up-regulates estrogen receptor (ER)-beta mRNA and protein levels in ER-positive breast cancer cells. [Breast Cancer Res] Abstract | Full Article

Eribulin Mesilate Suppresses Experimental Metastasis of Breast Cancer Cells by Reversing Phenotype from Epithelial-Mesenchymal Transition to Mesenchymal-Epithelial Transition States
Treatment of triple negative breast cancer cells with eribulin in vitro led to morphological changes consistent with transition from a mesenchymal to an epithelial phenotype. [Br J Cancer] Full Article

Conditional Over-Expression of Liver Receptor Homolog-1 in Female Mouse Mammary Epithelium Results in Altered Mammary Morphogenesis via the Induction of Transforming Growth Factor-ß
Researchers used siRNA knockdown strategies in order to deplete liver receptor homolog-1 (LRH-1) in breast cancer cells and followed with microarray analysis to identify LRH-1 dependent mechanisms. They identified key genes involved in TGF-ß signaling to be highly responsive to LRH-1 knockdown. [Endocrinology] Abstract

Wnt Modulates MCL1 to Control Cell Survival in Triple Negative Breast Cancer
Researchers directed their focus on identifying the WNT ligand and its underlying mechanism in triple negative breast cancer cells. [BMC Cancer] Abstract | Full Article

Targeting Met and Notch in the Lfng-Deficient, Met-Amplified Triple-Negative Breast Cancer
To examine roles of Met and Notch in triple negative breast cancer cells, scientists established two cell lines that harbor Met amplification as well as Lfng deletion, and possess features of basal and claudin-low breast cancer subtypes. [Cancer Biol Ther] Abstract

Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis
By using both human breast cancer cells and genetically engineered mice, researchers demonstrated that RBP2 is critical for breast cancer metastasis to the lung in multiple in vivo, models. [Cell Rep]
Full Article | Graphical Abstract

CLINICAL RESEARCH

Optimum Duration of Neoadjuvant Letrozole to Permit Breast Conserving Surgery
The aim of this multicenter, prospective, longitudinal Phase IV study was to establish the optimal duration of neoadjuvant letrozole that would allow breast conservation surgery in patients with early breast cancer who were initially unsuitable. [Breast Cancer Res Treat] Abstract

Disseminated Tumor Cells as a Monitoring Tool for Adjuvant Therapy in Patients with Primary Breast Cancer
Investigators aimed to assess whether adjuvant systemic therapy has the ability to eradicate disseminated tumor cells (DTC) and to determine the clinical impact of DTC-persistence. [Breast Cancer Res Treat] Abstract

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Eisai Announces Initiation of a Phase III Trial of Eribulin Mesylate Injection Versus Weekly Paclitaxel in First and Second Lines of Metastatic Breast Cancer
Eisai Inc. announced the start of a large, randomized Phase III trial to compare the efficacy, safety and tolerability of eribulin mesylate to standard weekly paclitaxel as a first- or second- line treatment for HER2-negative locally recurrent or metastatic breast cancer. [PR Newswire Association LLC] Press Release

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Postdoctoral Fellow – Process of Mammary Differentiation (University of British Columbia)

PhD Position – Grading CIN in the Mammary Gland (European Molecular Biology Laboratory)

Studentship – Microtubules and End-Binding Proteins in Epithelial Remodeling and Breast Cancer Invasion (University of East Anglia)

Postdoctoral Fellow – Mechanisms that Contribute to Metastases of Breast Cancer Cells (Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Hodgkin Lymphoma and Breast Cancer (Hackensack University Medical Center)

Postdoctoral Position – Functions of Epigenetic Enzymes in Breast Cancer (University of Wisconsin-Madison)

Postdoctoral Position – Breast Cancer Metastasis (Weizmann Institute of Science)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Research Fellow (Brigham & Women’s Hospital and Harvard Medical School)

Postdoctoral Position – Stem Cells and Cancer (Brigham & Women’s Hospital – Harvard Medical School)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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