Mammary Cell News Volume 6.16 | May 1 2014

NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis
To examine the impact of NCOA1 overexpression on morphogenesis and carcinogenesis in the mammary gland (MG), researchers generated MMTV-hNCOA1 transgenic mice. In the context of two distinct transgenic models of breast cancer, NCOA1 overexpression did not affect the morphology or tumor forming capability of MG epithelial cells. [Cancer Res] Abstract

Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Researchers report here that rhomboid family-1 expression in breast cancer is highly elevated and is strongly correlated with escalated disease progression, metastasis, poor prognosis, and poor response to chemotherapy. [Cancer Res] Abstract

SIP1/NHERF2 Enhances Estrogen Receptor Alpha Transactivation in Breast Cancer Cells
Investigators identified the protein Na+/H+ Exchanger Regulatory Factor 2 (NHERF2) as an estrogen receptor alpha (ERα)-associated coactivator that interacts predominantly with the AF-1 domain of the nuclear receptor. Overexpression of NHERF2 in breast cancer MCF7 cells produced an increase in ERα transactivation. [Nucleic Acids Res] Full Article

The Sodium Channel β1 Subunit Mediates Outgrowth of Neurite-Like Processes on Breast Cancer Cells and Promotes Tumor Growth and Metastasis
Scientists found that SCN1B mRNA/β1 protein were up-regulated in breast cancer (BCa) specimens, compared with normal breast tissue. β1 upregulation substantially increased tumor growth and metastasis in a xenograft model of BCa. [Int J Cancer] Full Article | Press Release

Induced Pluripotent Stem Cell-Derived Neural Stem Cells Transduced with Baculovirus Encoding CD40 Ligand for Immunogene Therapy in Mouse Models of Breast Cancer
Neural stem cells were derived from human induced pluripotent stem cells, transduced in vitro with a baculoviral vector encoding CD40 ligand, and intravenously injected into mice with orthotopic and metastatic breast cancers in immunocompetent mice. [Hum Gene Ther] Abstract

Dioscin Induces Caspase-Independent Apoptosis through Activation of Apoptosis-Inducing Factor in Breast Cancer Cells
Scientists found that dioscin treatment induced cell death in dose-dependent manner in breast cancer cells such as MDA-MB-231, MDA-MB-453, and T47D cells. Dioscin decreased expressions of Bcl-2 and cIAP-1 proteins, which were down-regulated at the transcriptional level. [Apoptosis] Abstract

Notch-1 Signaling Promotes the Malignant Features of Human Breast Cancer through NF-κB Activation
Using multiple cellular and molecular approaches, researchers demonstrated that activation of Notch-1 signaling pathway promoted the malignant behaviors of MDA-MB-231 cells such as increased cell proliferation, colony formation, adhesion, migration, and invasion, and inhibited apoptosis; whereas deactivation of this signaling pathway led to the reversal of the aforementioned malignant cellular behaviors. [PLoS One] Full Article

Down-Regulation of Asparagine Synthetase Induces Cell Cycle Arrest and Inhibits Cell Proliferation of Breast Cancer
Investigators employed RNA interference as an efficient tool to silence endogenous asparagine synthetase (ASNS) expression in breast cancer cell lines. The relationship between ASNS expression and breast cancer cell growth was investigated, and the therapeutic value of ASNS in breast cancer was further evaluated. [Chem Biol Drug Des] Abstract

CLINICAL RESEARCH

US Incidence of Breast Cancer Subtypes Defined by Joint Hormone Receptor and HER2 Status
Joint hormone receptor/human epidermal growth factor 2 (HER2) status distributions by age, race/ethnicity, county-level poverty, registry, stage, Bloom-Richardson grade, tumor size, and nodal status were evaluated using multivariable adjusted polytomous logistic regression. [J Natl Cancer Inst] Abstract

Population Pharmacometric Analyses of Eribulin in Patients with Locally Advanced or Metastatic Breast Cancer Previously Treated with Anthracyclines and Taxanes
Pharmacometric investigation of eribulin was undertaken in patients with metastatic breast cancer and other advanced solid tumors. A population pharmacokinetic model used data combined from seven Phase I studies, and one Phase II, and one Phase III study. [J Clin Pharmacol] Abstract

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Scripps Florida Scientists Awarded Grant to Develop New Diagnostics for Cancer, Rheumatoid Arthritis, Colitis
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis. [The Scripps Research Institute] Press Release

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NEW Research Technologist – hPSC (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Cancer Biology (University of Cincinnati)

Postdoctoral Fellow – Mechanisms that Contribute to Metastases of Breast Cancer Cells (Icahn School of Medicine at Mount Sinai)

PhD Position – Breast Cancer Translational Research Laboratory (Jules Bordet Institute)

Postdoctoral Position in Stem Cell and Cancer (Harvard Medical School)

Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

Junior Faculty Position – Breast Pathology (Northwestern University)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Breast Cancer Metastasis (Weizmann Institute of Science)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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