Mammary Cell News Volume 7.45 | Nov 19 2015

An EGFR/Src-Dependent β4 Integrin/FAK Complex Contributes to Malignancy of Breast Cancer
Scientists demonstrated for the first time physical and functional interactions between β4 integrin and FAK that influence breast cancer malignancy. [Sci Rep] Full Article

EpCAM Expression in Breast Cancer Cells Is Associated with Enhanced Bone Metastasis Formation
Investigators examined the roles of epithelial cell adhesion molecule (EpCAM) in the development of bone metastasis of breast cancer by using well-characterized animal models. Morphological and real-time RT-PCR data showed that the EpCAM-negative and -positive cell populations isolated from breast cancer cell lines exhibited mesenchymal and epithelial phenotypes, respectively. [Int J Cancer] Abstract

XBP1 Regulates the Biosynthetic Capacity of the Mammary Gland During Lactation by Controlling Epithelial Expansion and Endoplasmic Reticulum Formation
To assess the role of XBP1 in mammary epithelial cells, researchers studied floxed XBP1 female mice lacking or expressing the Cre recombinase under the control of the ovine β-lactoglobulin promoter. [Endocrinology] Abstract

Emerging Prognostic Markers Related to Mesenchymal Characteristics of Poorly Differentiated Breast Cancers
The authors investigated the correlation among poorly differentiated carcinoma, epithelial to mesenchymal transition phenomenon, and expression of NF-kB, Sonic hedgehog, K-RAS, and PTX3 in breast cancer in 100 breast biopsies. [Tumor Biol] Abstract

miR130b-Regulation of PPARγ Coactivator-1α Suppresses Fat Metabolism in Goat Mammary Epithelial Cells
Scientists utilized an improved microRNA (miRNA) detection assay, S-Poly-(T), to profile the expression of miRNAs in the goat mammary gland in different periods, and found that miR-130b was abundantly and differentially expressed in goat mammary gland. Additionally, overexpressing miR-130b impaired adipogenesis while inhibiting miR-130b enhanced adipogenesis in goat mammary epithelial cells. [PLoS One] Full Article

Assessment of Interactions between Cisplatin and Two Histone Deacetylase Inhibitors in MCF7, T47D and MDA-MB-231 Human Breast Cancer Cell Lines – An Isobolographic Analysis
Scientists investigated the influence of valproic acid and suberoylanilide hydroxamic acid, alone or in combination with cisplatin on proliferation, induction of apoptosis and cell cycle progression in MCF7, T47D and MDA-MB-231 human breast carcinoma cell lines. [PLoS One] Full Article

Gain-of-Function p53 Mutant with 21-bp Deletion Confers Susceptibility to Multidrug Resistance in MCF-7 Cells
Researchers investigated the role of a deletion spanning codons 127-133 in the p53 gene and its association with the proliferation, metastasis and drug resistance of MCF-7 cells. [Int J Mol Med] Abstract

CLINICAL RESEARCH

A Phase I Trial of BKM120 (Buparlisib) in Combination with Fulvestrant in Postmenopausal Women with Estrogen Receptor Positive Metastatic Breast Cancer
This trial was conducted to determine the maximum tolerated dose and preliminary efficacy of buparlisib, an oral pan-class I PI3K inhibitor, plus fulvestrant in postmenopausal women with metastatic estrogen receptor positive breast cancer. [Clin Cancer Res] Abstract

A Multicenter Prospective Phase II Trial of Neoadjuvant Epirubicin, Cyclophosphamide, and 5-Fluorouracil (FEC100) followed by Cisplatin–Docetaxel with or without Trastuzumab in Locally Advanced Breast Cancer
Investigators evaluated the efficacy and safety profile of FEC100 followed by cisplatin/docetaxel with and without trastuzumab as primary chemotherapy for patients with locally advanced breast cancer. [Cancer Chemother Pharmacol] Abstract

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Enterome and Gustave Roussy Enter into a Microbiome-Based Collaboration to Develop Novel Immunotherapy Solutions to Treat Cancer
Enterome Bioscience SA announced that it has entered into a collaborative development agreement with Gustave Roussy. They aim to develop of a new generation of drugs and non-invasive monitoring tools of the gut microbiome in immuno-oncology. [Enterome Bioscience SA] Press Release

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NEW Postdoctoral Position – Epigenetics and Cancer (Moffitt Cancer Center)

Cancer Biologist (Wake Forest Baptist School of Medicine)

Postdoctoral Research Fellow – Ovarian and Breast Cancer (Fred Hutchinson Cancer Research Center)

Academic Breast Pathologist (Beth Israel Deaconess Medical Center)

Group Leader Position – Cancer Research (Oslo University Hospital)

Postdoctoral Fellow – Metastatic Breast Cancer (Purdue University Center for Cancer Research)

Biological Imaging Scientist – 3D Cellular Models of Organs and Disease (University of Pittsburgh Drug Discovery Institute)

Postdoctoral Fellow – Tumor Dormancy (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Fellow – Metastatic Breast Cancer (Fred Hutchinson Cancer Research Center)

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