Mammary Cell News Volume 8.01 | Jan 14 2016

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
Researchers showed that a bivalent biparatopic antibody targeting two non-overlapping epitopes on HER2 can induce HER2 receptor clustering, which in turn promotes robust internalization, lysosomal trafficking, and degradation. [Cancer Cell] Abstract | Graphical Abstract

CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment
Potential biomarkers for bone metastasis were identified using proteomic comparison of bone-metastatic, lung-metastatic, and nonmetastatic variants of human breast cancer MDA-MB-231 cells. Clinical validation was performed using immunohistochemical staining of tumor tissue microarrays from patients in a large randomized trial of adjuvant zoledronic acid. [J Natl Cancer Inst] Abstract

Identification of p62/SQSTM1 as a Component of Non-Canonical Wnt VANGL2–JNK Signaling in Breast Cancer
Scientists showed that the archetypal Wnt/PCP protein VANGL2 is overexpressed in basal breast cancers, associated with poor prognosis and implicated in tumor growth. [Nat Commun] Full Article

A Novel Cell-Penetrating Peptide Suppresses Breast Tumorigenesis by Inhibiting Beta-Catenin/LEF-1 Signaling
Researchers attempted to synthesize a peptide (TAT-NLS-BLBD-6) that could interfere with the interaction of β-catenin and LEF-1 at nuclei in human breast cancer cells. [Sci Rep] Full Article

Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools
By combining extensive single-cell gene expression profiling with three functional strategies for cancer stem cell enrichment including anchorage-independent culture, hypoxia, and analyses of low-proliferative, label-retaining cells derived from mammospheres, investigators identified distinct stem cell clusters in breast cancer. [Stem Cell Reports] Full Article | Graphical Abstract

Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation
Scientists experimentally revealed that curcumin treatment reduced Akt protein expression in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells, along with an activation of autophagy and suppression of ubiquitin-proteasome system function. [PLoS One] Full Article

CLINICAL RESEARCH

Clinical Verification of Sensitivity to Preoperative Chemotherapy in Cases of Androgen Receptor-Expressing Positive Breast Cancer
A total of 177 patients with resectable early-stage breast cancer were treated with neoadjuvant chemotherapy. Estrogen receptor, progesterone receptor, HER2, Ki67 and androgen receptor status were assessed immunohistochemically. [Br J Cancer] Full Article

Androgen Receptor Expression Predicts Beneficial Tamoxifen Response in Estrogen Receptor-α-Negative Breast Cancer
In patients with estrogen receptor-negative tumors, expression of androgen receptor (AR) predicted decreased recurrence rate with tamoxifen, whereas the opposite was seen in the AR− group. [Br J Cancer] Abstract

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Saudi Food and Drug Authority Approves Gamma Medica’s LumaGEM^® Molecular Breast Imaging Solution
Gamma Medica, Inc. announced the Saudi Food and Drug Authority has issued a Medical Device Marketing Authorization for their LumaGEM^® breast imaging product. [Gamma Medica, Inc.] Press Release

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NEW Post-Doc Fellowship – Breast Cancer Functional Genomics (University of Cambridge)

NEW Post-Doc Fellowship – Breast Cancer Translational Research (University of Bern)

Post-Doc Fellowship – Breast/Ovarian Cancer Therapeutics (Fred Hutchinson Cancer Research Center)

Post-Doc Fellowship – Epidemiologist (German Cancer Research Center)

PhD Studentships – Various Projects (University of Cambridge)

Postdoctoral Researcher – Breast Tumor Image Analysis (Institute of Cancer Research)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

PhD Researcher – Cancer Signaling/Epigenetics/Tumor Biology (Institut Curie)

PhD Researcher – Personalized Immunotherapy for Cancer (ISPIC Consortium Members)

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