Mammary Cell News Volume 8.03 | Jan 28 2016

Cross-Kingdom Inhibition of Breast Cancer Growth by Plant miR159
Scientists found that Western donor sera contained the plant microRNA miR159, whose abundance in the serum was inversely correlated with breast cancer incidence and progression in patients. [Cell Res] Full Article

Rad51c– and Trp53 tumor-Double-Mutant Mouse Model Reveals Common Features of Homologous Recombination-Deficient Breast Cancers
Researchers demonstrated that deletion of Rad51c invariably requires inactivation of the Trp53 tumor suppressor (TP53 in humans) to produce mammary carcinomas in 63 percent of female mice. [Oncogene] Abstract

Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-Dependent Growth, Survival and Sensitivity towards Metformin in Breast Cancer Bone Metastasis
The authors investigated Runt-related transcription factor (Runx2) role in cell growth and metabolic signaling in bone-seeking breast cancer cells. They performed systemic inoculation of control or (Runx2) knockdown invasive MDA-MB-231 cells in NOD/SCID mice, and compared parental and bone-derived variants for phenotypic and molecular alterations. [Oncogene] Abstract

CDK9 Inhibitors Selectively Target Estrogen Receptor-Positive Breast Cancer Cells through Combined Inhibition of MYB and MCL-1 Expression
Researchers examined the effects of CDK9i on breast cancer cells and the involvement of MYB in these effects. Estrogen receptor-positive (ER^+ve) breast cancer cell lines including MCF-7 were much more sensitive to killing by CDK9i than ER-ve/MYB-ve cells. [Oncotarget] Full Article

The Dual Function of PRMT1 in Modulating Epithelial-Mesenchymal Transition and Cellular Senescence in Breast Cancer Cells through Regulation of ZEB1
Scientists showed that the epithelial-mesenchymal transition program induced by protein arginine methyltransferase 1 (PRMT1) endowed the human mammary epithelial cells with cancer stem cell properties. Moreover, PRMT1 promoted the migratory and invasive behaviors in breast cancer cells. [Sci Rep] Full Article

Correlating Confocal Microscopy and Atomic Force Indentation Reveals Metastatic Cancer Cells Stiffen during Invasion into Collagen I Matrices
Investigators found that actively invading and fully embedded cells are significantly stiffer than cells remaining on top of the collagen, a clear example of phenotypical change in response to the three-dimensional environment. [Sci Rep] Full Article

X-Linked Inhibitor of Apoptosis Protein Mediates Tumor Cell Resistance to Antibody-Dependent Cellular Cytotoxicity
Investigators demonstrated that the most potent caspase inhibitor, X-linked inhibitor of apoptosis protein, overexpressed in inflammatory breast cancer, drives resistance to antibody-dependent cellular cytotoxicity mediated by cetuximab (anti-EGFR) and trastuzumab (anti-HER2). [Cell Death Dis] Full Article

Combined Niclosamide with Cisplatin Inhibits Epithelial-Mesenchymal Transition and Tumor Growth in Cisplatin-Resistant Triple-Negative Breast Cancer
Scientists found that niclosamide or combination with cisplatin inhibited both 231-CS and 231-CR cell proliferation in vitro. In addition, niclosamide reversed the epithelial-mesenchymal transition phenotype of 231-CR by downregulation of snail and vimentin. [Tumour Biol] Abstract

Molecular Characterization of Irinotecan (SN-38) Resistant Human Breast Cancer Cell Lines
Scientists established breast cancer (BC) cell lines with acquired or de novo resistance to SN-38, by exposing the human BC cell lines MCF-7 and MDA-MB-231 to either stepwise increasing concentrations over 6 months or an initial high dose of SN-38 (the active metabolite of irinotecan), respectively. [BMC Cancer] Full Article

Autophagy Mediated by Arginine Depletion Activation of the Nutrient Sensor GCN2 Contributes to Interferon-γ-Induced Malignant Transformation of Primary Bovine Mammary Epithelial Cells
Scientist provide the first evidence of the correlation between IFN-γ treatment, autophagy and malignant transformation and of the mechanism underlying IFN-γ-induced autophagy and subsequent malignant transformation in primary bovine mammary epithelial cells. [Cell Death Discov] Full Article

CLINICAL RESEARCH

Serum Human Epidermal Growth Factor 2 Extracellular Domain as a Predictive Biomarker for Lapatinib Treatment Efficacy in Patients with Advanced Breast Cancer
Investigators analyzed serum human epidermal growth factor 2 (HER2) and tissue HER2 data from 1,902 patients who were randomly assigned to receive lapatinib or control in the trials EGF30001, EGF30008, and EGF100151. [J Clin Oncol] Abstract

Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer
Forty-five patients enrolled in nine dose cohorts plus five in an expansion cohort at the highest dose level and recommended phase II dose, 300 mg BID. Maximum tolerated dose of veliparib was not reached. [Clin Cancer Res] Abstract

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lifeIMAGE Acquires Mammosphere, an Innovative Network Enhancing Women’s Health Through Mammography Image Exchange
lifeIMAGE, the nation’s largest medical image exchange platform that enables imaging data interoperability across healthcare networks, providers and patients, announced that it has acquired Mammosphere, the leading national medical exchange network specializing in mammography and women’s imaging. [lifeIMAGE Inc.] Press Release

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NEW Clinical Pathways Associate – Cancer Therapeutics (Fred Hutchinson Cancer Research Center)

Clinical Researcher – Breast Cancer (Massachusetts General Hospital-Cancer Center)

Post-Doc Fellowship – Breast Cancer Development (University of Pennsylvania)

Post-Doc Fellowship/PhD Studentship – Cancer Cell-Tumor Microenvironment Interactions (University of Helsinki)

Academic Surgical Pathologist – Breast Pathology (Northwestern University)

Post-Doc Fellowship – Breast Cancer Functional Genomics (University of Cambridge)

Post-Doc Fellowship – Breast Cancer Translational Research (University of Bern)

Post-Doc Fellowship – Breast/Ovarian Cancer Therapeutics (Fred Hutchinson Cancer Research Center)

Post-Doc Fellowship – Epidemiologist (German Cancer Research Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

PhD Researcher – Cancer Signaling/Epigenetics/Tumor Biology (Institut Curie)

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