Mammary Cell News Volume 8.26 | Jul 7 2016

TOP STORY

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells

An abnormal differentiation state is common in BRCA1-deficient mammary epithelial cells, but the underlying mechanism is unclear. Scientists report a convergence between DNA repair and normal, cultured human mammary epithelial cell differentiation. [Mol Cell] Abstract

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

COPS5 Amplification and Overexpression Confers Tamoxifen-Resistance in ERα-Positive Breast Cancer by Degradation of NCoR

Using integrated genomic and functional studies, scientists report that amplification and/or overexpression of COPS5 confers resistance to tamoxifen. [Nat Commun] Full Article

The Landscape of Chromosomal Aberrations in Breast Cancer Mouse Models Reveals Driver-Specific Routes to Tumorigenesis

Researchers experimentally validate that loss of Stratifin promotes HER2-induced tumorigenesis in human cells. Their results demonstrate the power of genetically engineered mouse model copy-number alteration analysis to inform the pathogenesis of human cancer. [Nat Commun] Full Article

Hormone‐Induced Repression of Genes Requires BRG1‐Mediated H1.2 Deposition at Target Promoters

The authors report that in breast cancer cells, ligand‐activated progesterone receptor is directly recruited to transcriptionally repressed genes involved in cell proliferation along with the kinases ERK1/2 and MSK1. [EMBO J] Abstract | Graphical Abstract | Press Release

Inhibition of DNA Methylation Promotes Breast Tumor Sensitivity to Netrin-1 Interference

Scientists showed that a substantial fraction of human breast tumors exhibits simultaneous DNA methylation-dependent loss of expression of NTN1 and of DAPK1, a serine threonine kinase known to transduce the netrin-1 dependence receptor pro-apoptotic pathway. [EMBO Mol Med] Full Article

TNFα-Activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis by Recruiting CXCR2⁺ Neutrophils

Employing a lung metastasis model of murine breast cancer, the authors found that tumor necrosis factor α (TNFα)-activated mesenchymal stromal cells (MSCs) strikingly enhanced tumor metastasis compared with normal MSCs. [Oncogene] Full Article

Apigenin Inhibits the Inducible Expression of Programmed Death Ligand 1 by Human and Mouse Mammary Carcinoma Cells

Investigators showed that the dietary phytochemical apigenin inhibited interferon-γ-induced programmed death ligand 1 (PD-L1) upregulation by triple-negative MDA-MB-468 BC cells, HER2M⁺ SK-BR-3 breast cancer (BC) cells, and 4T1 mouse mammary carcinoma cells, as well as human mammary epithelial cells, but did not affect constitutive PD-L1 expression by triple-negative MDA-MB-231 BC cells. [Cancer Lett] Abstract

Stiffness of the Microenvironment Upregulates ERBB2 Expression in 3D Cultures of MCF10A within the Range of Mammographic Density

The effects of the stiffness of the microenvironment on the molecular response of 3D colony organization, at the maximum level of mammographic density, were investigated. [Sci Rep] Full Article

Disrupting VEGF-A Paracrine and Autocrine Loops by Targeting SHP-1 Suppresses Triple Negative Breast Cancer Metastasis

Scientists investigated the potential of regorafenib to suppress metastasis of triple-negative breast cancer (TNBC) cells through targeting SHP-1/p-STAT3/VEGF-A axis. They found a significant correlation between cancer cell migration and SHP-1/p-STAT3/VEGF-A expression in human TNBC cells. [Sci Rep] Full Article

MicroRNA-145 Functions as a Tumor Suppressor by Targeting Matrix Metalloproteinase 11 and Rab GTPase Family 27a in Triple-Negative Breast Cancer

The expression of microRNA (miR)-145 in human triple-negative breast cancer (TNBC) cells and samples from 30 patients was analyzed by stem-loop real-time PCR. Researchers found that miR-145 was significantly downregulated in TNBC tissues and cells. [Cancer Gene Ther] Abstract

CLINICAL RESEARCH

Tumor-Infiltrating Lymphocytes (TILs) Are a Powerful Prognostic Marker in Patients with Triple-Negative Breast Cancer Enrolled in the IBCSG Phase III Randomized Clinical Trial 22-00

The purpose of this study was to assess the prognostic and predictive value of TILs in the triple-negative breast cancer cohort of the Phase III IBCSG trial 22-00, comparing low-dose oral ‘metronomic’ cyclophosphamide-methotrexate maintenance chemotherapy (CM-maintenance) to no-CM-maintenance in early breast cancer. [Breast Cancer Res Treat] Abstract

Multifaceted Breast Cancer: The Molecular Connection with Obesity

The authors describe how adipose inflammation that characterizes obesity is responsible of microenvironment to promote cancer, and discuss how steroid hormones, that are essential for the maintenance of the normal development, growth and differentiation of the cells, influence the induction and progression of breast cancer. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Elsevier Launches PracticeUpdate Metastatic Breast Cancer Center of Excellence

Elsevier announced that it has launched its newest PracticeUpdate Center of Excellence (COE) focused on metastatic breast cancer. The COE, an important new benefit for PracticeUpdate members, brings together medical experts in oncology to discuss and provide relevant treatment advice and disease information on metastatic breast cancer. [Elsevier] Press Release

Puma Biotechnology Submits Marketing Authorization Application for PB272 (Neratinib) as Extended Adjuvant Treatment of HER2-Positive Early Stage Breast Cancer in Europe

Puma Biotechnology, Inc. announced that it has submitted its Marketing Authorization Application to the European Medicines Agency for neratinib. The potential indication is for the extended adjuvant treatment of HER2-positive early stage breast cancer that has previously been treated with trastuzumab-based adjuvant therapy. [Puma Biotechnology] Press Release

NCI Launches Largest-Ever Study of Breast Cancer Genetics in Black Women

The largest study ever to investigate how genetic and biological factors contribute to breast cancer risk among black women launched. This collaborative research project will identify genetic factors that may underlie breast cancer disparities. The effort is funded by the National Cancer Institute, part of the National Institutes of Health. [National Institute of Health/National Cancer Institute] Press Release

Policy Implications of Aging in the NIH-Funded Workforce

Because of national interest in the “graying” of the biomedical workforce, the authors examine aging and funding within the pool of NIH-funded investigators and applicants, particularly in the growing field of stem cell research. They provide evidence of a maturing and more competitive stem cell workforce and discuss policy implications. [Cell Stem Cell] Editorial

NEW 2016 World Cancer Congress
October 31-November 3, 2016
Paris, France

Visit our events page to see a complete list of events in the mammary cell community.

NEW Postdoctoral Fellow – Various Projects (National University of Singapore)

NEW Postdoctoral Fellow – Breast Cancer Monitoring through Digital Imaging (University Rovira i Virgili)

Research Technologist – Mammary and Prostate Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Breast Cancer Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Basic & Translational Breast Cancer Research (Northwestern Universtiy)

Postdoctoral Associate – Premalignant Progression to Invasive Breast Cancer (Tulane Medical School)

Postdoctoral Fellow – Molecular Genetics of Breast Cancer (German Cancer Research Centre)

Postdoctoral Researcher – Aheransotic Agents against Intracellular Cancer Targets (University of Oxford)

Postdoctoral Fellowship – Cancer Research (German Cancer Research Center)

Postdoctoral Fellow – Proteogenomic Bioinformatics of Breast Cancer (Lund University)

Postdoctoral Fellow – Cancer Biology (Hamad bin Khalifa University)

PhD Fellow – Small X-Ray Angle for Breast Cancer Diagnosis (CEA Tech)

Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

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