Mammary Cell News 8.33 August 25, 2016 | |
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TOP STORY70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. Researchers sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical–pathological criteria in selecting patients for adjuvant chemotherapy. [N Engl J Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHResearchers have uncovered an important spindle assembly role of the RNF20/40 complex, and implicated the RNF20/40-Eg5 axis in breast carcinogenesis, supporting the pursuit of these proteins as potential targets for breast cancer therapeutic interventions. [Nat Commun] Full Article Stratification and Therapeutic Potential of PML in Metastatic Breast Cancer Researchers showed that promyelocytic leukemia protein (PML) is a novel target in aggressive breast cancer. The acquisition of aggressiveness and metastatic features in breast tumors is accompanied by the elevated PML expression and enhanced sensitivity to its inhibition. [Nat Commun] Full Article Interleukin-30 Promotes Breast Cancer Growth and Progression The inflammatory tissue microenvironment which promotes the development of breast cancer (BRCA) is not fully understood. Researchers reported a role for elevated interleukin-30 in supporting the BRCA cell viability and invasive migration. [Cancer Res] Abstract Addiction to the IGF2-ID1-IGF2 Circuit for Maintenance of the Breast Cancer Stem-Like Cells Investigators identified insulin-like growth factor 2 (IGF2) is a key target of nuclear factor-κB activated by HER2/HER3 signaling to form tumor spheres in breast cancer cells. [Oncogene] Full Article Scientists found that downregulation of Alpha1,2-fucosyltransferases (FUT1), which leads to the perinuclear localization of lysosome-associated membrane protein 1 (LAMP)-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR signaling and increasing autolysosome formation. [Cell Death Dis] Full Article Investigators characterized for the first time the mammary epithelial stem/progenitor cells in the common marmoset. The mammary stem cell-enriched cells formed four major types of morphologically distinct colonies when cultured on plates pre-seeded with irradiated NIH3T3 fibroblasts, and were also capable of forming mammospheres in suspension culture and subsequent formation of 3D organoids in Matrigel culture. [Sci Rep] Full Article The ELK3-GATA3 Axis Orchestrates Invasion and Metastasis of Breast Cancer Cells In Vitro and In Vivo Investigators showed that ELK3 is overexpressed in a subset of breast cancers, in particular basal-like and normal-like/claudin-low cell lines. Suppression of ELK3 in MDA-MB-231 cells led to transdifferentiation from an invasive mesenchymal phenotype to a non-invasive epithelial phenotype both in vitro and in vivo. [Oncotarget] Full Article CLINICAL RESEARCHHER2 Expression Identifies Dynamic Functional States Within Circulating Breast Cancer Cells Scientists analyzed circulating tumor cells from 19 women with estrogen-receptor (ER)+/human epidermal growth factor receptor 2 (HER2)− primary tumors, 84% of whom had acquired circulating tumor cells expressing HER2. [Nature] Abstract | Press Release Scientists investigated gene expression profiles of the NF-κB pathway in patients with TNBC receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. [Sci Rep] Full Article | |
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REVIEWSOncogenic and Tumor-Suppressive Mouse Models for Breast Cancer Engaging HER2/Neu To understand the pathophysiology of HER2-driven carcinogenesis and test HER2-targeting therapeutic agents in vivo, numerous mouse models have been created that faithfully reproduce HER2(+) breast cancers in mice. [Int J Cancer] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSChinese FDA Grants MammaTyper® Innovative Product Status for Expedited Approval BioNTech Diagnostics GmbH and its Chinese partner Shuwen Biotech Co. Ltd. announced that the Chinese FDA has granted the “Innovative Medical Product” status for MammaTyper®, a real-time PCR kit for breast cancer stratification. [BioNTech Diagnostics GmbH] Press Release UCF Technology for Killing Metastatic Breast Cancer Cells Discovered, Licensed A UCF College of Medicine cancer researcher has discovered a way to kill spreading breast cancer cells and her new technology has generated a licensing agreement that will accelerate the therapy’s path to clinical trials. [University of Central Florida] Press Release | |
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POLICY NEWSNew Leader of NIH’s Research Watchdog Faces Staff Revolt The Office of Research Integrity (ORI) in Rockville, Maryland, which guards against misconduct in biomedical research, usually attracts attention with its findings, not its internal workings. But two years ago, its director, David Wright, quit in a public huff, complaining that ORI was hobbled by a dysfunctional federal bureaucracy. Now, his successor is encountering her own rough waters. [Nature News] Editorial Obama’s Science Legacy: Uneven Progress on Scientific Integrity Many researchers who watched Barack Obama’s inauguration in 2009 were thrilled by his pledge to “restore science to its rightful place”. But scientists and legal scholars say that, in many ways, Obama has failed to live up to that lofty promise. [Nature News] Editorial Updated: Companies Settle Gene Technology Patent Fight That Was Shrouded in Mystery Illumina Inc. and Oxford Nanopore Technologies have reached a settlement in this legal battle, according to a U.S. International Trade Commission document released last week. Oxford has agreed not to import or sell any product containing a pore with an amino acid sequence at least 68% similar to Mycobacterium smegmatis porin — the protein at the heart of Illumina’s infringement claim — and to destroy any inventory of such products. [ScienceInsider] Editorial Putin Appoints Church Historian as Science Minister Russian President Vladimir Putin has appointed a church historian as the country’s new science and education minister. The president announced that Olga Vasilyeva would succeed the current science minister, Dmitry Livanov, who will become presidential envoy on trade and economic relations with Ukraine, according to the Russian news agency Interfax. [Nature News] Editorial
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EVENTSNEW Advances in Cell Engineering, Imaging, and Screenings Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Pathologist – Breast Pathology (University of California Los Angeles) NEW Postdoctoral Researcher – Breast Cancer (Purdue University) Postdoctoral and PhD Positions – Personalized Medicine for Breast Cancer (University of Basel) Product Specialist – Oncology (Celgene Corporation) Robert Stowell Chair – Experimental Pathology (University of California, Davis) Lead Bioinformatician – Cancer-Related Genes and Targeted Drugs (Institute of Cancer Research) Postdoctoral Position – Metastatic Reactivaction of Cancer (MD Anderson Cancer Center) Scientific Director – Oncology (Merck) Postdoctoral Fellow – Various Projects (National University of Singapore) Postdoctoral Fellow – Breast Cancer Monitoring through Digital Imaging (University Rovira i Virgili) Postdoctoral Fellowship – Cancer Research (German Cancer Research Center) Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center) Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mammary Cell News Volume 8.33 | Aug 25 2016