Mammary Cell News 8.42 October 27, 2016 | |
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TOP STORYResearchers identified PIM1, a non-essential serine–threonine kinase, in a synthetic lethal interaction with MYC. PIM1 expression was higher in triple-negative tumors than in receptor-positive tumors and was associated with poor prognosis in patients with hormone- and HER2-negative tumors. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHScientists identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with triple-negative breast cancers. [Nat Med] Abstract Investigators report that FOXK2 interacts with transcription corepressor complexes NCoR/SMRT, SIN3A, NuRD, and REST/CoREST to repress a cohort of genes including HIF1β and EZH2 and to regulate several signaling pathways including the hypoxic response. [Cancer Cell] Abstract | Graphical Abstract Researchers evaluated how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer. [J Clin Invest] Full Article Wnt and Neuregulin1/ErbB Signaling Extends 3D Culture of Hormone Responsive Mammary Organoids Current three-dimensional mammary culture systems have not demonstrated concurrent proliferation and functional differentiation ex vivo in any system for longer than 2 weeks. Investigators identified conditions including Neuregulin1 and R-spondin 1, allowing maintenance and expansion of mammary organoids for 2.5 months in culture. [Nat Commun] Full Article Researchers studied the interplay between p53 loss and Wnt/β-catenin signaling in stem cell function and tumorigenesis, by deleting p53 from the mammary epithelium of K5ΔNβcat mice displaying a constitutive activation of Wnt/β-catenin signaling in basal cells. [Oncogene] Abstract Recently myoferlin has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion of cancer cells. The authors report a consistent overexpression of myoferlin in triple-negative breast cancer cells over cells originating from other breast cancer subtypes. [Oncogene] Abstract Liposomal Prednisolone Inhibits Tumor Growth in a Spontaneous Mouse Mammary Carcinoma Model The authors investigated the antitumor effect of liposomal corticosteroids in transgenic mice developing spontaneous breast carcinomas. [J Control Release] Abstract Scientists observed that 91H, H19 and IGF2 are overexpressed in breast tumors. By using 91H-knockdown breast cancer cells, they demonstrated that 91H exerts oncogenic properties by promoting cell growth, migration and invasion as well as tumor growth in xenografted immunodeficient mouse model. [Cancer Lett] Abstract CLINICAL RESEARCHThe authors investigated the effect of copper depletion using tetrathiomolybdate on the tumor microenvironment in preclinical models. [Clin Cancer Res] Abstract | Full Article | |
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REVIEWSThe authors describe the types of heterogeneity so far identified and the key role played by the epithelial-to-mesenchymal transition in driving circulating tumor cells heterogeneity. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSAnti-HER3 Monoclonal Antibody Patritumab Selected for I-SPY 2 TRIAL in Breast Cancer Daiichi Sankyo Company, Limited and QuantumLeap Healthcare Collaborative announced that a new treatment arm of the I-SPY2 TRIAL will include patritumab, an investigational anti-HER3 monoclonal antibody. [Daiichi Sankyo Company, Limited] Press Release How Does the Gut Microbiome Influence Breast Cancer? Researchers from the University of Illinois at Chicago and the University of Chicago have received a three-year, $900,000 Defense Department grant to investigate how the gut microbiome influences breast cancer. [University of Illinois] Press Release BERG announced that it has entered into a Cooperative Research and Development Agreement with partners of the Department of Defense’s Clinical Breast Care Project including Walter Reed National Military Medical Center, The Windber Research Institute and The Henry Jackson Foundation for the Advancement of Military Medicine, to advance breast cancer research and develop personalized treatment strategies for breast cancer patients. [BERG, LLC ( PR Newswire Association LLC)] Press Release OncoDNA SA has signed a partnership agreement, through its Spanish distributor BioSequence, with SOLTI, to supply tumor molecular profiling analysis for SOLTI’s AGATA breast cancer screening program. [OncoDNA (Business Wire, Inc)] Press Release Mersana Announces FDA Clearance of IND Application for Lead Antibody-Drug Conjugate XMT-1522 Mersana Therapeutics, Inc. announced that the U.S. Food and Drug Administration cleared the company’s Investigational New Drug application to begin Phase I clinical trials for its lead oncology drug candidate XMT-1522. The compound is Mersana’s first pipeline product, and defines a new class of HER2-targeted therapies. [Mersana Therapeutics] Press Release $596K Grant Supports Examination of Chronic Stress in Breast Cancer Development Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, has received a $596,250 Breakthrough Award from the U.S. Department of Defense through its Breast Cancer Research Program to study the role of chronic stress in breast cancer development. [Rutgers, The State University of New Jersey] Press Release | |
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POLICY NEWSScientific Challenges Loom for Canada’s Popular Prime Minister Many in Canada’s science community say they are reserving judgement, waiting to see whether Trudeau can sustain his string of victories as he tackles some of country’s thorniest science-policy issues. [Nature News] Editorial Review Finds Misconduct in Events Surrounding WHO Fetal Growth Study For the first time in its 68-year history, the World Health Organization (WHO) has concluded that researchers are guilty of research misconduct. An independent review commissioned by WHO has found that “research ethics misconduct occurred” in a multimillion-dollar global study on fetal growth led by researchers at the University of Oxford in the United Kingdom. [ScienceInsider] Editorial Two Major California Research Institutes Will Merge One of the biggest nonprofit biomedical research outfits in the world is getting a new translational medicine research arm, aimed at speeding the conversion of basic research insights into novel medicines. Officials at the Scripps Research Institute announced that it will merge with the California Institute for Biomedical Research, which was launched in 2012 as a nonprofit version of a drug development company. [ScienceInsider] Editorial To Save Money, NSF Requires University Cost-Sharing for Rotators The National Science Foundation (NSF) has decided that universities should pay 10% of the salaries of faculty members working temporarily at the agency. NSF hopes the new policy will demonstrate its commitment to saving taxpayer dollars without alienating the academic community that it relies upon to stay on the cutting edge of basic science. [ScienceInsider] Editorial
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EVENTSNEW 4th Immunotherapy of Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow- Breast Cancer Research (Icahn School of Medicine at Mount Sinai) NEW Postdoctoral Position – Immunology (Inserm) Postdoctoral Training Fellow (Institute of Cancer Research) Research Associate – Patient-Derived Organoid Models of Breast Cancer (King’s College London) Postdoctoral Fellow – BioMarker Research Cancer (Houston Methodist Research Institute) Postdoctoral Associate – Mammary Stem Cell and Cancer Biology (University of Miami) Postdoctoral Position – Neovascularization and Cancer Biology (The Ohio State University) Postdoctoral Associate – Functional Genomics and Cancer (The Jackson Laboratory) Assistant Professor – Physiology and Biophysics (University of Illinois at Chicago) Postdoctoral Researcher – Breast Cancer (Purdue University) Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mammary Cell News Volume 8.42 | Oct 27 2016