Mammary Cell News 8.45 November 17, 2016 | |
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TOP STORYPalbociclib and Letrozole in Advanced Breast Cancer The authors performed a Phase III study that was designed to confirm and expand the efficacy and safety data for palbociclib plus letrozole for treatment of postmenopausal women with estrogen-receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer. [N Engl J Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHThe authors established a tamoxifen resistant MCF-7 cell line (MCF-7-Tam-R) by continuously incubating MCF-7 cells with 4-OH-tamoxifen. They found that melanoma cell adhesion molecule (MCAM/CD146), a unique epithelial-to-mesenchymal transition inducer, was significantly up-regulated at both mRNA and protein levels in MCF-7-Tam-R cells compared to parental MCF-7 cells. [Cancer Lett] Full Article Scientists investigated the role of thioredoxin reductase 1 (TrxR1) in dysplastic transformation of human breast epithelial cell line MCF-10A induced by chronic oxidative stress. TrxR1 is a pivotal intracellular redox sensor and antioxidant enzyme. [Sci Rep] Full Article Investigators evaluated alternative antiangiogenic therapies, which target multiple VEGF family members or differentially modulate the Angiopoietin/Tie2 pathway, in a mouse model of resectable triple-negative breast cancer. [Sci Rep] Full Article Researchers found that Notch3 inhibits epithelial–mesenchymal transition by activating the Hippo/YAP pathway by upregulating Kibra in breast cancer epithelial cells, and Kibra is a downstream effector of Notch3. [Oncogenesis] Full Article TRIM28 Multi-Domain Protein Regulates Cancer Stem Cell Population in Breast Tumor Development Investigators evaluated the role of tripartite motif-containing protein 28 (TRIM28) in the regulation of breast cancer stem cell (CSC) populations and tumorigenesis in vitro and in vivo. They demonstrated that the downregulation of TRIM28 gene expression reduced the ability of CSCs to self-renew that resulted in significant reduction of tumor growth. [Oncotarget] Full Article The authors identified high expression of lncRNA H19 as a powerful factor associated with paclitaxel (PTX) resistance in ERα-positive breast cancer cells, but not in ERα-negative breast cancer cells. LncRNA H19 attenuated cell apoptosis in response to PTX treatment by inhibiting transcription of pro-apoptotic genes BIK and NOXA. [Oncotarget] Full Article miR-199a-5p Confers Tumor-Suppressive Role in Triple-Negative Breast Cancer Researchers investigated the functional implication of miR(microRNA)-199a-5p in triple-negative breast cancer (TNBC) and its potential underlying mechanisms. For the first time, the tumor-suppressive role of miR-199a-5p in TNBC was discovered. [BMC Cancer] Full Article miR-124-3p Functions as a Tumor Suppressor in Breast Cancer by Targeting CBL Scientists found that miR(microRNA)-124-3p was consistently downregulated in breast cancer tissues. They showed that miR-124-3p significantly suppressed the proliferation and invasion of breast cancer cells. [BMC Cancer] Full Article NTN4 Is Associated with Breast Cancer Metastasis via Regulation of EMT-Related Biomarkers Investigators revealed that nerve guidance factor 4 (NTN4) was decreased in breast cancer compared with normal breast tissues. NTN4 is associated with breast cancer cell migration and invasion via regulation of epithelial mesenchymal transition (EMT)-related biomarkers. [Oncol Rep] Abstract CLINICAL RESEARCHScientists showed that substituting nab-paclitaxel for standard solvent-based paclitaxel significantly improved the pathologic complete response rate achieved with a sequential neoadjuvant chemotherapy regimen of paclitaxel, epirubicin and cyclophosphamide for high-risk primary breast cancer. [Ann Oncol] Abstract | |
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REVIEWSPIN1 in Breast Development and Cancer: A Clinical Perspective The authors discuss PIN1’s roles in normal mammary development and cancerous progression, as well as the clinical impact of targeting this enzyme in breast cancer patients. [Cell Death Differ] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSGTx, Inc. announced the achievement of the Stage 1 milestone for the 18 mg cohort of its Phase II clinical trial of enobosarm to treat women with advanced, estrogen receptor positive (ER+), androgen receptor positive (AR+) breast cancer. [GTx, Inc.] Press Release Roche launched the global cancer immunotherapy Centers of Research Excellence (imCORE™) Network. This network brings together many of the world’s leading scientific and clinical experts in cancer immunotherapy to collaborate in investigating the most promising new treatment approaches. [Roche] Press Release Van Andel Research Institute, in collaboration with Cedars-Sinai, has received a $2.5 million, five-year grant from the National Cancer Institute, part of the National Institutes of Health, that will fuel efforts by investigators to uncover the underpinnings of cancer, ultimately helping scientists develop better diagnostic and treatment strategies for a class of diseases that claim more than eight million lives each year worldwide. [Van Andel Institute] Press Release | |
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POLICY NEWSArgentina President’s First Budget Angers Scientists Researchers in Argentina are incensed about budget cuts that look set to hit the nation’s science ministry especially hard next year—even though President Mauricio Macri pledged to boost science spending when he took office. [Nature News] Editorial Biomedical Research Leaders Urge Trump Administration to Quickly Appoint an NIH Director A science star–studded group that including two former directors of the National Institutes of Health (NIH) in Bethesda, Maryland, released a set of recommendations aimed at making NIH run better and offered advice on choosing an NIH director—ideally within Trump’s first 100 days in office. [Science Insider] Editorial Canary Islands Scientists Up in Arms After Airlines Stop Shipping Research Animals Two major airlines have stopped transporting laboratory animals from mainland Spain to the Canary Islands, an archipelago in the Atlantic Ocean. Their move has put research projects on the islands on hold and has left scientists and politicians scrambling for solutions. The ban is particularly problematic for researchers who need transgenic mice, which are often ordered from specialized labs. The issue may soon be debated in the Spanish parliament; some members want the federal government in Madrid to force the companies to lift their ban, according to a story in Spanish newspaper El PaÃs. [Science Insider] Editorial
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EVENTSNEW 19th International Conference on Clinical Application of Adult Stem Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Breast Cancer Research (Dana-Farber Cancer Institute) NEW Bioinformatician – Breast Cancer (Queen Mary University of London) NEW Postdoctoral Fellow – Cancer Prevention Studies (American Cancer Society) Research Fellow – Breast Cancer Research (University of New Mexico Comprehensive Cancer Center) Postdoctoral Position – Immunology (Inserm) Postdoctoral Training Fellow (Institute of Cancer Research) Postdoctoral Fellow – BioMarker Research Cancer (Houston Methodist Research Institute) Postdoctoral Associate – Mammary Stem Cell and Cancer Biology (University of Miami) Postdoctoral Position – Neovascularization and Cancer Biology (The Ohio State University) Postdoctoral Associate – Functional Genomics and Cancer (The Jackson Laboratory) Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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