Mammary Cell News 9.00 January 5, 2017 | |
| |
TOP STORYA Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland Scientists identified a quiescent mammary epithelial cell population expressing high levels of Bcl11b and located at the interface between luminal and basal cells. Bcl11bhigh cells are enriched for cells that can regenerate mammary glands in secondary transplants. [Cell Stem Cell] Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHGpr132 Sensing of Lactate Mediates Tumor–Macrophage Interplay to Promote Breast Cancer Metastasis Investigators showed that G protein-coupled receptor 132 (Gpr132) functions as a key macrophage sensor of the rising lactate in the acidic tumor milieu to mediate the reciprocal interaction between cancer cells and macrophages during breast cancer metastasis. [Proc Natl Acad Sci USA] Abstract RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer PARP inhibitors have shown promising results in early studies for treatment of breast cancer susceptibility gene (BRCA)–deficient breast cancers; however, resistance ultimately develops. Researchers demonstrated that the cancer stem cells in BRCA1-mutant triple-negative breast cancers were resistant to PARP inhibition, and that these cells had both elevated RAD51 protein levels and activity. [Clin Cancer Res] Abstract HIC1 and miR-23~27~24 Clusters Form a Double-Negative Feedback Loop in Breast Cancer Scientists showed that all members of the miR-23~27~24 clusters are upregulated and function as oncogenes in breast cancer and simultaneously target HIC1. Furthermore, they found that HIC1 functions as a transcriptional repressor to negatively control the expression of miR-23~27~24 clusters and forms a double-negative (overall positive) feedback loop. [Cell Death Differ] Full Article Metabotypes of Breast Cancer Cell Lines Revealed by Non-Targeted Metabolomics Investigators presented an analysis of intracellular metabolism by non-targeted, high-throughput metabolomics profiling of 18 breast cell lines. The identified metabotypes recapitulated functional differences at the pathway level. [Metab Eng] Abstract Somatostatin Receptor Targeted Liposomes with Diacerein Inhibit IL-6 for Breast Cancer Therapy Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. A synthetic somatostatin analogue was used as SSTR2 targeting agent and diacerein was employed as therapeutic molecule. [Cancer Lett] Abstract | Graphical Abstract Functional Roles of Sialylation in Breast Cancer Progression through miR-26a/26b Targeting ST8SIA4 Scientists investigated the N-glycan profiles of breast cancer patients and cell lines to reveal sialylation associated with breast cancer progression, and provided new evidences of miRNA-mediated sialylation. The forced expression of miR-26a/26b was able to induce a decrease of ST8SIA4 level and also to affect breast cancer cells progression, while altered expression of ST8SIA4 in breast cancer cells modulated progression upon transfection with miR-26a/26b mimics or inhibiter. [Cell Death Dis] Full Article The authors adopted a gene co-expression network approach that draws on the functional parallels between naturally occurring bone marrow-derived mesenchymal stem cells and cancer stem cells. Knockdown of RARRES3 in near-normal mammary epithelial and breast cancer cell lines increased overall transcript and protein levels of the immunoproteasome subunits, but not of their constitutively expressed counterparts. [Sci Rep] Full Article Heparanase Augments Insulin Receptor Signaling in Breast Carcinoma Researchers analyzed clinical samples of breast carcinoma derived from diabetic/non-diabetic patients, and investigated effects of heparanase on insulin signaling in breast carcinoma cell lines, as well as insulin-driven growth of breast tumor cells. [Oncotarget] Full Article Prolactin (PRL)-induced activation of the transcription factor signal transducer and activator of transcription 5 (STAT5) results in the upregulation of numerous genes implicated in breast cancer pathogenesis. The authors showed that PRL signaling induces chromatin decompaction at promoter DNA, corresponding with STAT5 binding. [J Biol Chem] Abstract | Full Article Scientists investigated the effects of MK-8776 on the radiosensitivity of 3 human triple-negative breast cancer cell lines MDA-MB-231, BT-549 and CAL-51. MK-8776 dose-dependently inhibited the proliferation of MDA-MB-231, BT-549 and CAL-51 cells. [Acta Pharmacol Sin] Full Article Cysteine-rich protein 61 (CCN1/Cyr61) has been implicated as an important mediator in the proliferation and metastasis of breast cancer. Researchers reported that baicalein significantly inhibits the expression of Cyr61 and migration and invasion of MDA-MB231 human breast cancer cells. Further analysis revealed that baicalein inhibited the expression of lysyl oxidase like-2 (LOXL-2). [Mol Cells] Full Article CLINICAL RESEARCHAmong women with ERBB2-positive metastatic breast cancer receiving taxanes, the use of a proposed trastuzumab biosimilar compared with trastuzumab resulted in an equivalent overall response rate at 24 weeks. [JAMA] Abstract | Press Release | |
| |
REVIEWSThe author reviews recent work delineating mechanisms by which hypoxia-inducible factor 1 mediates adaptive metabolic responses to hypoxia, including increased flux through the glycolytic pathway and decreased flux through the tricarboxylic acid cycle, in order to decrease mitochondrial reactive oxygen species production. [EMBO J] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
| |
INDUSTRY NEWSBiocept, Inc. announced that Columbia University Medical Center will conduct a study to evaluate the clinical utility of the company’s Target Selector™ platform to diagnose leptomeningeal metastases in patients with breast cancer. [Biocept, Inc.] Press Release Genomic Health, Inc. announced that based on unparalleled clinical evidence, the American Joint Committee on Cancer (AJCC) incorporated the Oncotype DX® test in its recently published Eighth Edition AJCC Cancer Staging Manual. [Genomic Health, Inc.] Press Release | |
| |
POLICY NEWSUS Scientists Fear New Restrictions on Fetal-Tissue Research House Republicans conclude that tissue from aborted fetuses is of limited value for research and seek to reduce funding. [Nature News] Editorial Argentina’s Researchers Occupy Science Ministry Hundreds of young researchers occupied Argentina’s science ministry in Buenos Aires last month, angry at budget cuts that they say have denied them permanent jobs at the country’s National Scientific and Technical Research Council. The occupation was the most extreme action yet by Argentinian scientists after months of protests at last year’s budget, the first under President Mauricio Macri. And the occupation seems to have paid off, in part: many of those involved have been offered extensions to their fellowships. [Nature News] Editorial
| |
EVENTSNEW 19th International AEK Cancer Congress Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoc Position – Mammary Epithelium and Breast Cancer (Helmholtz Association) NEW Postdoctoral Fellow – Breast Cancer (University of Hawaii Cancer Center) NEW Postdoctoral Fellow – Cancer Biology (University of Illinois) Two Postdoctoral Opportunities – Cancer Epigenetics (International Agency for Research on Cancer) Postdoctoral Researcher – Nuclear Medicine Dosimetry (University of Oxford) Postdoctoral Fellow – Breast Cancer Biology (Icahn School of Medicine at Mount Sinai) Postdoctoral Associate – Mammary Stem Cell and Cancer Biology (University of Miami) Assistant Professor – Molecular Therapeutics of Cancer (Dartmouth College) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mammary Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|