Mammary Cell News 9.18 May 11, 2017 | |
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TOP STORYSingle-Cell RNA-Seq Enables Comprehensive Tumor and Immune Cell Profiling in Primary Breast Cancer The authors analyzed 515 cells from 11 patients. Inferred copy number variations from the single-cell RNA-seq data separate carcinoma cells from non-cancer cells. At a single-cell resolution, carcinoma cells displayed common signatures within the tumor as well as intratumoral heterogeneity regarding breast cancer subtype and crucial cancer-related pathways. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHInhibition of PTP1B Disrupts Cell–Cell Adhesion and Induces Anoikis in Breast Epithelial Cells Researchers analyzed the protein tyrosine phosphatase 1B (PTP1B) expression in normal breast tissue, primary breast cells and the breast epithelial cell line D492. In normal breast tissue and primary breast cells, PTP1B was widely expressed in both epithelial and stromal cells, with highest expression in myoepithelial cells and fibroblasts. [Cell Death Dis] Full Article Scientists showed that co-treatment of anoikis-resistant MDA-MB-231 cells with metformin and 2-deoxy-D-glucose increased the percentage of floating cells, of which about 95% were viable. Floating cells resumed their proliferation once they were reseeded in the pharmacological compound-free medium. [Sci Rep] Full Article The authors observed an inverse correlation between Slug, a zinc-finger transcriptional repressor, and estrogen receptor α (ERα) expression in both human breast cancer tissues and cell lines. In ERα-negative breast cancer patients, high Slug messenger RNA expression showed obviously shorter relapse-free survival. [Oncogenesis] Full Article G Protein-Coupled Receptor GPR19 Regulates E-Cadherin Expression and Invasion of Breast Cancer Cells Investigators showed that overexpression of G protein-coupled receptor (GPR)19 drives mesenchymal-like breast cancer cells to adopt an epithelial-like phenotype, as demonstrated by the upregulation in E-cadherin expression and changes in functional behavior. [Biochim Biophys Acta] Abstract ATP-P2Y2-β-Catenin Axis Promotes Cell Invasion in Breast Cancer Cells Researchers found that P2Y2 was highly expressed in breast cancer cells and associated with human breast cancer metastasis. ATP could promote the in vitro invasion of breast cancer cells and enhance the expression of β-catenin as well as its downstream target genes CD44, c-Myc and cyclin D1, while P2Y2 knockdown attenuated above ATP-driven events in vitro and in vivo. [Cancer Sci] Abstract The authors demonstrated roles of STIMs in TGF-β-induced epithelial–mesenchymal transition (EMT) in breast cancer cells. In particular, STIM1 and STIM2 expression affected TGF-β-induced EMT by mediating store-operated calcium entry in MDA-MB-231 and MCF-7 breast cancer cells. [Biochem Biophys Res Commun] Abstract Scientists evaluated the selectivity profile, apoptotic cell death and cell cycle arrest induced by 7-chloroquinoline-1,2,3-triazoyl carboxamides derivatives in hormonal-dependent and hormonal-independent breast cancer cells. [Biomed Pharmacother] Abstract CLINICAL RESEARCHtAnGo was an international, open-label, randomized, Phase III superiority trial that enrolled women aged 18 years or older with newly diagnosed, early-stage breast cancer who had a definite indication for chemotherapy, any nodal status, any hormone receptor status, Eastern Cooperative Oncology Group performance status of zero to one, and adequate bone marrow, hepatic, and renal function. [Lancet Oncol] Abstract The effect on whole-transcriptome mRNA expression was investigated in a randomized Phase II clinical trial to assess the effect of neoadjuvant chemotherapy with the addition of bevacizumab. [Clin Cancer Res] Abstract | |
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REVIEWSMammary Stem Cells: Premise, Properties, and Perspectives The authors review recent advances – discussing fundamental unresolved properties of mammary stem cell potency, dynamics, and plasticity – and point to evolving technologies that promise to shed new light on this intractable debate. [Trends Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSOncolytics Biotech® Inc. announced that the United States Food and Drug Administration (FDA) has granted Fast Track designation for REOLYSIN®, the company’s proprietary immuno-oncology viral agent, for the treatment of metastatic breast cancer. [Oncolytics Biotech® Inc.] Press Release Novartis announced that the US Food and Drug Administration (FDA) has approved the Kisqali® Femara® Co-Pack for the treatment of hormone receptor-positive, human epidermal growth factor receptor-2 negative advanced or metastatic breast cancer in postmenopausal women. [Novartis (PR Newswire Association LLC.)] Press Release EpiThany announced that they have entered into a collaboration agreement with Merck KGaA and Pfizer to evaluate avelumab, a human anti-PD-L1 antibody, and EP-101 STEMVAC, a multi-antigen, polyepitope vaccine, in a Phase II trial in women with breast cancer. [EpiThany] Press Release Duke, NCCU Researchers Receive $2 Million Grant to Study Rare Form of Breast Cancer A new grant from the National Cancer Institute will support researchers at Duke and North Carolina Central University in their joint fight against a rare type of cancer. Collaborators at Duke and NCCU recently received a $2 million grant from the National Cancer Institute to study cancer disparities amongst different races. [The Chronicle] Press Release Einstein Shares in $2.9 Million Grant to Combat Breast Cancer Metastasis Researchers at Albert Einstein College of Medicine and three other institutions are sharing a five-year, $2.9 million grant from the National Cancer Institute to study how different types of cells influence breast cancer metastasis. [Albert Einstein College of Medicine] Press Release | |
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POLICY NEWSThe Secret War against Counterfeit Science China is famous for knock-off DVDs, Louis Vuitton bags and Rolex watches. But counterfeit reagents aren’t on sale in busy public markets. They are sold through sophisticated websites, mixed in with legitimate supplies, and sourced and sold using a network of unwitting partners. [Nature News] Editorial Science Publishers Try New Tack to Combat Unauthorized Paper Sharing The unauthorized sharing of copyrighted research papers is on the rise, say analysts who track the publishing industry. Faced with this problem, science publishers seem to be changing tack in their approach to researchers who breach copyright. [Nature News] Editorial Biotech Execs, Academic Leaders Make Case for NIH Funding at White House Meeting Could the Trump administration be changing its mind about slashing funding for the National Institutes of Health (NIH)? Scientific leaders were optimistic after meeting at the White House with several biotech executives to discuss the “ecosystem” in which federally funded basic research leads to discoveries that companies turn into treatments. [ScienceInsider] Editorial
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EVENTSNEW The TGF-β Superfamily: Signaling in Development and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Statistical Bioinformatician – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Positions – Cancer Research (Baylor College of Medicine) Researcher – Tumor Microenvironment and Invasion Program (SUNY Upstate Medical University) Postdoctoral Research – Cancer Biology (University of Pennsylvania) Bioinformatics Scientist – Breast Cancer (Windber Research Institute) Postdoctoral Fellow – Breast Cancer Stem Cell (University of Kentucky) Postdoctoral Position – Metastatic Breast Cancer (Purdue University) Postdoctoral Associate – Mammary Stem Cell and Cancer Biology (University of Miami) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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