Mammary Cell News Volume 9.23 | Jun 15 2017

TOP STORY

Metastatic Breast Cancer Cells Use Hedgehog to ‘Evilize’ Docile Neighbors

Researchers showed that metastatic breast cancer cells signal neighboring cells in ways that allow otherwise anchored cells to metastasize. They pinpoint a promising link in the chain of signaling that, when broken, could reduce the metastatic potential of the disease. [Press release from the University of Colorado Cancer Center discussing online publication in Nature Communications] Press Release | Full Article

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

The lncRNA H19 Mediates Breast Cancer Cell Plasticity during EMT and MET Plasticity by Differentially Sponging miR-200b/c and let-7b

Using a mouse model of spontaneous metastatic breast cancer, the authors investigated the molecular mediators of metastatic competence within a heterogeneous primary tumor and how these cells then manipulated their epithelial-mesenchymal plasticity during the metastatic process. [Sci Signal] Full Article

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3

To investigate phenotypic and genotypic alterations before and after bone metastasis, scientists conducted genome-wide mRNA profiling and DNA exon sequencing of two cell lines derived from a mouse xenograft model. [Sci Rep] Full Article

TRPC5-Induced Autophagy Promotes Drug Resistance in Breast Carcinoma via CaMKKβ/AMPKα/mTOR Pathway

Researchers demonstrated that adriamycin up-regulated both levels of TRPC5 and autophagy, and that the increase in autophagy was mediated by TRPC5 in breast cancer cells. Blockade of TRPC5 or autophagy increased the sensitivity to chemotherapy in vitro and in vivo. [Sci Rep] Full Article

Molecular Characterization of Breast Cancer Cell Lines through Multiple Omic Approaches

The authors characterized a large, commonly employed panel of breast cancer cell lines obtained from the American Type Culture Collection to enable researchers to make more informed decisions in selecting cell lines for specific studies. [Breast Cancer Res] Full Article

MLK3 Regulates FRA-1 and MMPs to Drive Invasion and Transendothelial Migration in Triple-Negative Breast Cancer Cells

Researchers report that in non-metastatic, estrogen receptor-positive breast cancer cells, induced mixed-lineage kinase 3 (MLK3) expression robustly upregulates the oncogenic transcription factor, FOS-related antigen-1 (FRA-1), which is accompanied by elevation of matrix metalloproteinases (MMPs), MMP-1 and MMP-9. [Oncogenesis] Full Article

Proline-Rich Homeodomain Protein (PRH/HHEX) Is a Suppressor of Breast Tumor Growth

To determine the consequences of PRH loss of function in breast cancer cells, investigators generated inducible PRH depletion in MCF-7 cells. They showed that PRH depletion resulted in increased MCF-7 cell proliferation in part at least due to increased vascular endothelial growth factor signaling. [Oncogenesis] Full Article | Press Release

Identification of a Novel p53 Target, COL17A1, that Inhibits Breast Cancer Cell Migration and Invasion

Scientists unveiled ten novel p53 target candidates that were up-regulated after the induction of p53 in wild-type cells. Their expressions were also high in breast invasive carcinoma tissues with wild-type p53. [Oncotarget] Full Article

A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells

By displaying various targeting peptides on the EV surface, investigators observed that although displaying GE11 on extracellular vesicles (EVs) modestly increased uptake by MCF-7 cells, NPY display had no effect on uptake by the same cells. In contrast, NTS and uPA display reduced EV uptake by MDA-MB-231 cells. [Tissue Eng Part A] Abstract

Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells

Researchers compared estrogenic activity of bisphenol A to 6 bisphenol analogues in three human breast cancer cell lines. Estrogenicity was assessed by cell growth in an estrogen receptor-mediated cell proliferation assay, and by the induction of estrogen response element-mediated transcription in a luciferase assay. [Toxicol Sci] Abstract | Full Article

Brain-Derived Neurotrophic Factor (BDNF) -TrKB Signaling Modulates Cancer-Endothelial Cells Interaction and Affects the Outcomes of Triple Negative Breast Cancer

The authors investigated the role of BDNF on the tumor cell microenvironment, namely, the cancer cell-endothelial cell interaction of TNBC cells. [PLoS One] Full Article

CLINICAL RESEARCH

Accelerated versus Standard Epirubicin Followed By Cyclophosphamide, Methotrexate, and Fluorouracil or Capecitabine as Adjuvant Therapy for Breast Cancer in the Randomized UK TACT2 Trial (CRUK/05/19): A Multicenter, Phase III, Open-Label, Randomized, Controlled Trial

In this multicenter, Phase III, randomized, controlled trial, scientists enrolled patients aged 18 years or older from 129 UK centres who had histologically confirmed node-positive or high-risk node-negative operable breast cancer, had undergone complete excision, and were due to receive adjuvant chemotherapy. [Lancet Oncol] Full Article

27-Hydroxycholesterol: A Novel Player in Molecular Carcinogenesis of Breast and Prostate Cancer

The authors highlight recent findings pertaining to the role of 27 hydroxycholesterol in breast cancer and PCa and delineates the signaling mechanisms involved in the governing of different facets of tumor biology, that include tumor cell proliferation, epithelial-mesenchymal transition, as well as tumor cell invasion, migration, and metastasis. [Chem Phys Lipids] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

OncoSec Announces Technology Access Program Agreement with Jounce Therapeutics, Inc.

OncoSec Medical Incorporated announced that they have engaged in a preclinical agreement through the OncoSec Technology Access Program with Jounce Therapeutics, Inc. Under the agreement, Jounce can utilize OncoSec’s gene delivery technology to evaluate in vivo efficacy in murine models of intratumorally-delivered therapeutic candidates. [OncoSec Medical Incorporated] Press Release

DanDrit Biotech Announces New Therapeutic Research Strategy

DanDrit Biotech USA, Inc. announced that Mr. Rene Sindlev and Mr. Torben Bjørn Christensen joined DanDrit’s Board of Directors as part of a new strategy to expand the company’s focus beyond its ongoing clinical drug trials to develop new therapeutic programs to treat cancer and other serious diseases. [DanDrit Biotech USA, Inc.] Press Release

Texas Has Sanctioned Unapproved Stem Cell Therapies. Will It Change Anything?

Texas Governor Greg Abbott signed a bill allowing clinics and companies in the state to offer people unproven stem cell interventions without the testing and approval required under federal law. Like the “right to try” laws that have sprung up in more than 30 states, the measure is meant to give desperately ill patients access to experimental treatments without oversight from the U.S. Food and Drug Administration. [ScienceInsider] Editorial

Empty Rhetoric over Data Sharing Slows Science

Government agencies lack the funds to build platforms for data sharing and resist taking responsibility for such infrastructure. They may hope that universities will host data, but the development of institutional repositories is patchy, and to rely on them is effectively to discourage common data standards and curation. [Nature News] Editorial

NEW Tumor Immunology and Immunotherapy
October 1-4, 2017
Boston, Massachusetts, United States

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NEW Postdoctoral Training Fellow – Bioinformatics and Cancer Metabolism (The Francis Crick Institute)

Clinician Investigator – Breast Cancer Research (Mayo Clinic)

Cancer Bioinformatician – Breast Cancer (Institute of Cancer Research)

Postdoctoral Research Associate – Breast Cancer (University of Nebraska Medical Center)

Research Position – Translational Breast Cancer Research (Northwestern University)

Postdoctoral Training Fellow – Cancer Metabolism (The Francis Crick Institute)

Postdoctoral Fellow – Metastatic Breast Cancer Stem Cells (Memorial Sloan-Kettering Cancer Center)

Postdoctoral Researcher Positions – Fundamental Mechanisms of Tyrosine Kinase Mediated Epigenetic Modifications (Moffitt Comprehensive Cancer Center)

Postdoctoral Positions – Cancer Research (Baylor College of Medicine)

Researcher – Tumor Microenvironment and Invasion Program (SUNY Upstate Medical University)

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