Mammary Cell News 9.24 June 22, 2017 | |
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TOP STORYZEB1-Regulated Inflammatory Phenotype in Breast Cancer Cells Investigators identified a zinc finger E-box binding protein 1 (ZEB1)-regulated inflammatory phenotype in breast cancer cells using chromatin immunoprecipitation-sequencing and RNA sequencing, followed by gene set enrichment analysis of ZEB1-bound genes. [Mol Oncol] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHOptofluidic Device for the Quantification of Circulating Tumor Cells in Breast Cancer Researchers designed and demonstrated a 3D-flow focusing microfluidic device, where all optics were integrated into the chip, for the fluorescence quantification of CTCs in real samples. [Sci Rep] Full Article Methylation of DACT2 Promotes Breast Cancer Development by Activating Wnt Signaling To explore the role of disheveled-associated antagonist of β-catenin (DACT)2 in breast cancer, five cell lines and 153 cases of primary cancer were studied. The expression of DACT2 was detected in BT474, MDA-MB-231 and BT549 cells, while no expression was found in MDA-MB-468 and HBL100 cells. [Sci Rep] Full Article Functional studies showed that inhibition of miR-23a suppressed the TGF-β1-induced epithelial-mesenchymal transition (EMT), migration, invasion and metastasis of breast cancer both in vitro and in vivo. [Oncotarget] Full Article Secretory Pathway Ca2+-ATPases Promote In Vitro Microcalcifications in Breast Cancer Cells Scientists report on a rapid and quantitative in vitro assay to monitor microcalcifications in breast cancer cell lines, including MCF7, MDA-MB-231 and Hs578T. They showed that the secretory pathway Ca2+-ATPases SPCA1 and SPCA2 are strongly induced under osteogenic conditions that elicit microcalcifications. [Mol Carcinog] Abstract The authors present a novel method to characterize the response of breast cancer cells to drug stimuli through use of off-chip passivated-electrode insulator-based dielectrophoresis and the application of AC electric fields. [Electrophoresis] Abstract E2F8 Confers Cisplatin Resistance to ER+ Breast Cancer Cells via Transcriptionally Activating MASTL The authors investigated the mechanism of its dysregulation in breast cancer and its involvement in cisplatin resistance in ER+ breast cancer cells. [Biomed Pharmacother] Abstract CLINICAL RESEARCHInvestigators performed a multicenter, open label Phase II trial of the addition of Irosustat to a first-line aromatase inhibitor (AI) in patients with advanced BC to evaluate the safety of the combination and to test the hypothesis that the addition of Irosustat to AI may further suppress estradiol levels and result in clinical benefit. [Breast Cancer Res Treat] Abstract Data were obtained from the Cancer and Leukemia Group B (CALGB) 40502 trial, a randomized Phase III trial of paclitaxel vs. nab-paclitaxel vs. ixabepilone as first-line chemotherapy for locally recurrent or metastatic breast cancer. Chemotherapy-induced peripheral neuropathy was measured using a subset of the Functional Assessment of Cancer Therapy-Gynecologic Oncology Group Neurotoxicity scale. [AAPS J] Abstract | |
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REVIEWSViral Gene Therapy for Breast Cancer: Progress and Challenges The authors describe the therapeutic strategies that are currently under development to treat breast cancer using engineered viral vectors including: adenovirus, adeno-associated virus, lentivirus, poxvirus, reovirus, baculovirus, herpesvirus and oncolytic viruses. [Expert Opin Biol Ther] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSMenarini Ricerche and the UK company Oxford BioTherapeutics will present the latest data about their novel antibody drug-conjugate (ADC) MEN1309/OBT076, in development for solid and hematological tumors. [Press release from Menarini Ricerche discussing research to be presented at the 29th Pezcoller Symposium, Trento] Press Release | |
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INDUSTRY NEWSHuntsman Cancer Institute Unveils New Primary Children’s and Families’ Cancer Research Center Huntsman Cancer Institute (HCI) at the University of Utah announced the official opening of its Primary Children’s and Families’ Cancer Research Center. Jon M. Huntsman also announced a commitment from the Huntsman family and Huntsman Cancer Foundation to give $120 million to HCI. [Huntsman Cancer Institute] Press Release Tessa Therapeutics and the Parker Institute for Cancer Immunotherapy announced the establishment of a multi-year strategic alliance to combine their capabilities to jointly advance research in the field of cancer immunotherapy. [Tessa Therapeutics Pte Ltd.] Press Release | |
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POLICY NEWSUniversity of Tokyo Scientist Hit by Anonymous Allegations Fights Back Anonymous allegations of questionable data and images in 22 papers by six prominent groups at the prestigious University of Tokyo prompted the school to set up an investigating committee. Now, even before the panel completes its investigation, one of the accused researchers has mounted a staunch defense of his work. [ScienceInsider] Editorial China Cracks Down on Fake Peer Reviews The Chinese government is going on the offensive against scientists who dupe journals by creating fraudulent reviews of submitted papers. A coalition of agencies led by the science ministry announced that the government would suspend the grants of researchers involved in such fraud, which surfaced earlier this year when a cancer journal retracted 107 research papers from Chinese authors. [Nature News] Editorial Strengthened US Sanctions on Cuba Disappoint Scientists US President Donald Trump announced that he would strengthen travel and trade restrictions against Cuba, reversing his predecessor’s attempts to normalize relations with the country. The move is a blow to scientists who hoped that former president Barack Obama’s push to relax US restrictions on Cuba would make it easier for researchers there to travel and to collaborate with colleagues in the United States. [Nature News] Editorial
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EVENTSNEW 2017 National Cancer Research Institute (NCRI) Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Assistant – Breast Cancer (University of British Columbia) NEW Research Fellow – Breast Cancer Research (Monash University) Postdoctoral Training Fellow – Bioinformatics and Cancer Metabolism (The Francis Crick Institute) Clinician Investigator – Breast Cancer Research (Mayo Clinic) Cancer Bioinformatician – Breast Cancer (Institute of Cancer Research) Postdoctoral Research Associate – Breast Cancer (University of Nebraska Medical Center) Research Position – Translational Breast Cancer Research (Northwestern University) Postdoctoral Fellow – Metastatic Breast Cancer Stem Cells (Memorial Sloan-Kettering Cancer Center) Postdoctoral Positions – Cancer Research (Baylor College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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