Mammary Cell News 9.25 June 29, 2017 | |
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TOP STORYMutant p53 Dictates the Oncogenic Activity of c-Abl in Triple-Negative Breast Cancers Researchers showed that c-Abl is predominantly restricted to the cytoplasm of human MDA-MB-231 TNBC cells, and to the nucleus of human MCF-7 luminal A cells. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHDACH1 Suppresses Breast Cancer as a Negative Regulator of CD44 A mouse transplanted tumor model indicated that breast cancer cells Met-1 with up-regulation of dachshund homolog 1 (DACH1) were endowed with remarkably reduced potential of tumorigenesis. [Sci Rep] Full Article Vitamin D Modulation of TRAIL Expression in Human Milk and Mammary Epithelial Cells Western blot analysis of total cell lysate obtained from normal human mammary epithelial cells treated with variable doses of vitamin D for 24 hours demonstrated that low levels significantly increased the tumor necrosis factor-related apoptosis inducing ligand (TRAIL) α but no change in β expression. [Sci Rep] Full Article Scientists showed that intraductal cisplatin and poly (ADP)-ribose polymerase 1-inhibition can successfully ablate mammary epithelial cells, and this approach attenuated tumor onset in a mouse model of Brca1-associated breast cancer from 153 to 239 days. [Oncotarget] Full Article The authors adopted a phosphoproteomic-based approach to identify salt modulated kinase-proteome specific molecular targets. The phosphoprotemics based binary comparison between heavy labelled MCF-7 cells treated with high salt and light labelled MCF-7 cells cultured under basal conditions demonstrated an enhanced phosphorylation of Serine-493 of SIK3 protein. [PLoS One] Full Article Synergistic Cytotoxic Effects of Arsenite and Tetrandrine in Human Breast Cancer Cell Line MCF-7 To provide novel insight into the development of new therapeutic strategies to combat breast cancer using trivalent arsenic (AsIII)-based combination therapy, the cytotoxicity of a combination of AsIII and tetrandrine, a Chinese plant-derived alkaloid, was investigated in the human breast cancer cell line MCF-7. [Int J Oncol] Abstract The authors evaluated the effect of HS-1793 on hypoxia-inducible factor-1α (HIF-1α), which drives angiogenesis and the growth of solid tumors, in addition to the in vivo therapeutic effects of HS-1793 on breast cancer cells. [Int J Oncol] Abstract Scientists investigated whether apigenin is able to reverse drug resistance using adriamycin-resistant breast cancer cells. Apigenin significantly decreased cell growth and colony formation in MCF-7/ADR cells and parental MCF-7 cells. [Oncol Rep] Abstract Investigators showed that salinomycin is effective in inhibiting MCF-7/LCC2 and MCF-7/LCC9 cell lines which are well-established endocrine resistant cells and have a synergistic effect in combination with tamoxifen using a MTT proliferation assay. [Clin Exp Pharmacol Physiol] Abstract CLINICAL RESEARCHTumor Uptake of 64Cu-DOTA-Trastuzumab in Patients with Metastatic Breast Cancer Researchers characterized the relationship between tumor uptake of 64Cu-DOTA-trastuzumab as measured by PET/CT and standard, immunohistochemistry-based, histopathologic classification of human epidermal growth factor receptor 2 status in women with metastatic breast cancer. [J Nucl Med] Abstract The efficacy and safety of palbociclib, a cyclin-dependent kinase 4/6 inhibitor, combined with fulvestrant and goserelin was assessed in premenopausal women with advanced breast cancer who had progressed on prior endocrine therapy. [Oncologist] Abstract | |
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REVIEWSMUC1 Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer The authors enumerate the role of MUC1-C proto-oncogene in tamoxifen resistance and describe a number of signaling pathways by which MUC1-C would mediate the development of resistance. [Expert Rev Anticancer Ther] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSTapImmune, Inc. announced that it has enrolled 50% of the patients in its randomized Phase II clinical study of its novel T-cell vaccine candidate TPIV 200 for treating triple-negative breast cancer. [TapImmune, Inc.] Press Release Cell Medica Acquires WT1 Cancer Immunotherapy from Cell and Gene Therapy Catapult Cell Medica announced the acquisition of Catapult Therapy TCR Limited and the initiation of a collaboration to establish cell therapy manufacturing for Cell Medica at CGT Catapult’s GMP manufacturing facility in Stevenage, UK. [Cell Medica] Press Release | |
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POLICY NEWSCanada’s Basic Science at Risk of Fading Away, Report Argues Canada’s scientific enterprise is at risk of sinking to junk bond status as a result of a funding crunch and misguided government and granting council policies, argues a report. In particular, the authors decry a steady shift away from basic science that has left a smaller portion of the nation’s growing scientific community focused on fundamental research. [ScienceInsider] Editorial Putin Tightens Control over Russian Academy of Sciences The Russian government has taken further steps to tighten its grip on the Russian Academy of Sciences (RAS) in Moscow. The State Duma—one of the two chambers of the Russian parliament—passed the first draft of a new law that would give president Vladimir Putin the final say in the elections for RAS’s presidency. [ScienceInsider] Editorial
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EVENTSNEW San Antonio Breast Cancer Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Positions – Breast Cancer (Northwestern University – Feinberg School of Medicine) NEW Postdoctoral Training Fellow – Cancer Metabolism (The Francis Crick Institute) Research Assistant – Breast Cancer (University of British Columbia) Research Fellow – Breast Cancer Research (Monash University) Postdoctoral Training Fellow – Bioinformatics and Cancer Metabolism (The Francis Crick Institute) Clinician Investigator – Breast Cancer Research (Mayo Clinic) Cancer Bioinformatician – Breast Cancer (Institute of Cancer Research) Postdoctoral Research Associate – Breast Cancer (University of Nebraska Medical Center) Research Position – Translational Breast Cancer Research (Northwestern University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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