Mammary Cell News Volume 9.31 | Aug 10 2017

TOP STORY

Response to Radiotherapy after Breast-Conserving Surgery in Different Breast Cancer Subtypes in the Swedish Breast Cancer Group 91 Radiotherapy Randomized Clinical Trial

Researchers evaluated the effect of adjuvant radiotherapy after breast conservation surgery in different breast cancer subtypes in a large, randomized clinical trial with long-term follow-up. [J Clin Oncol] Full Article

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

Genomic Profiling of ER⁺ Breast Cancers after Short-Term Estrogen Suppression Reveals Alterations Associated with Endocrine Resistance

Scientists profiled 155 ER⁺/human epidermal growth factor receptor 2–negative (HER2⁻) early breast cancers from 143 patients treated with the aromatase inhibitor letrozole for 10 to 21 days before surgery. Twenty-one percent of tumors remained highly proliferative, suggesting that these tumors harbor alterations associated with intrinsic endocrine therapy resistance. [Sci Transl Med] Abstract

Molecular Characterization of Breast Cancer CTCs Associated with Brain Metastasis

Investigators report that breast cancer brain metastasis circulating tumor cells (CTCs) are enriched in a distinct sub-population of cells identifiable by their biomarker expression and mutational content. Deriving from a comprehensive analysis of CTC transcriptomes, they discovered a unique “CTC gene signature” that is distinct from primary breast cancer tissues. [Nat Commun] Full Article

Nanogrid Single-Nucleus RNA Sequencing Reveals Phenotypic Diversity in Breast Cancer

The authors compared the transcriptomes of 485 single nuclei to 424 single cells in a breast cancer cell line, which showed a high concordance in gene levels and abundance. [Nat Commun] Full Article

Estrogen Receptor Coregulator Binding Modulators (ERXs) Effectively Target Estrogen Receptor Positive Human Breast Cancers

Researchers have developed a novel estrogen receptor alpha (ER) coregulator binding modulator, ERX-11. ERX-11 interacts directly with ER and blocks the interaction between a subset of coregulators with both native and mutant forms of ER. [eLife] Full Article | Press Release

ErbB2-Positive Mammary Tumors Can Escape PI3K-p110α Loss through Downregulation of the Pten Tumor Suppressor

Clinical and experimental data have shown that breast tumors treated with a p110α-specific inhibitor often circumvent inhibition and resume growth. To understand this mechanism of resistance, scientists crossed a p110α conditional mouse model with mice that overexpress the ErbB2/Neu-IRES-Cre transgene specifically in the mammary epithelium. [Oncogene] Abstract

Breast Tumors Educate the Proteome of Stromal Tissue in an Individualized but Coordinated Manner

To characterize how patient breast tumors form a niche and educate naïve stroma, subcutaneous breast cancer patient-derived xenografts were globally profiled by species-specific quantitative proteomics. [Sci Signal] Full Article

Connexin-43 Enhances Tumor Suppressing Activity of Artesunate via Gap Junction-Dependent as Well as Independent Pathways in Human Breast Cancer Cells

Scientists exploited the antitumor property of the gap junction protein connexin-43 (Cx43) in conjunction with the artesunate (ART), a plant-based active anti-malarial compound. They revealed that expression of Cx43 helped in reducing the dose-dependent cytotoxicity of ART as well as enhanced the bystander apoptosis of the neighboring cells. [Sci Rep] Full Article

H-Ferritin-Nanocaged Olaparib: A Promising Choice for Both BRCA-Mutated and Sporadic Triple Negative Breast Cancer

The authors developed H-Ferritin nanoformulated olaparib and assessed its anticancer efficacy on both BRCA-mutated and non-mutated triple-negative breast cancer cells. [Sci Rep] Full Article

Lysine Demethylase KDM2A Inhibits TET2 to Promote DNA Methylation and Silencing of Tumor Suppressor Genes in Breast Cancer

Investigators demonstrated that knockdown of lysine demethylase 2A (KDM2A) significantly increased the 5′-hydroxymethylcytosine level in genomic DNA and expression of tet-eleven translocation 2 (TET2) in various breast cancer cell lines. [Oncogenesis] Full Article

CLINICAL RESEARCH

Effect of Neoadjuvant Chemotherapy on Tumor-Infiltrating Lymphocytes and PD-L1 Expression in Breast Cancer and Its Clinical Significance

Researchers assessed stromal tumor-infiltrating lymphocytes and programmed death ligand 1 (PD-L1) protein expression in a cohort of breast cancer patients treated with neoadjuvant chemotherapy. [Breast Cancer Res] Full Article

AKT1^low Quiescent Cancer Cells Persist after Neoadjuvant Chemotherapy in Triple Negative Breast Cancer

Scientists asked whether quiescent cancer cells exist in primary tumors from patients with triple negative breast cancer and persist after treatment with neoadjuvant chemotherapy. [Breast Cancer Res] Full Article

Prognostic and Predictive Importance of the Estrogen Receptor Coactivator AIB1 in a Randomized Trial Comparing Adjuvant Letrozole and Tamoxifen Therapy in Postmenopausal Breast Cancer: The Danish Cohort of Big 1-98

Investigators evaluated the estrogen receptor coactivator amplified in breast cancer 1 (AIB1) as a prognostic marker, as well as a predictive marker for response to adjuvant tamoxifen and/or aromatase inhibitors, in early estrogen receptor-positive breast cancer. [Breast Cancer Res Treat] Full Article

Aberrantly miRNA Promoter Methylation and EMT-Involving miRNAs in Breast Cancer Metastasis: Diagnosis and Therapeutic Implications

The authors examine the interplay of DNA methylation mechanisms and miRNA function in invasive tumorigenesis, specifically epithelial-mesenchymal transition (EMT) of breast cancer, to highlight its potential for advancements on breast cancer etiology, diagnosis and therapy. [J Cell Physiol] Abstract

MACF1, a Novel Potential Target in Cancer

Aberrant expression of microtubule actin cross-linking factor 1 (MACF1) initiates the tumor cell proliferation, migrations and metastasis in numerous cancers such as breast cancer, colon cancer, lung cancer and glioblastoma. Scientists summarize the current knowledge of (MACF1) and its critical role in different human cancer. [Cancer Sci] Abstract

Altered Glutamine Metabolism in Breast Cancer; Subtype Dependencies and Alternative Adaptations

The most recent findings in breast cancer cell metabolism are discussed, with particular emphasis on glutamine and its transporters which is considered one of the key amino acids fueling cancer growth. Furthermore, the metabolic differences between the molecular subtypes of breast cancer are examined, highlighting the clinical utility for breast cancer diagnosis and treatment. [Histopathology] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Cancer Research Institute and Israel Cancer Research Fund Announce Launch of The Immunotherapy Promise Initiative

The Cancer Research Institute and Israel Cancer Research Fund announced the establishment of The Immunotherapy Promise™ fund, a groundbreaking, collaborative campaign bringing together the leading funder of immunotherapy research internationally with North America’s largest nonprofit dedicated to supporting Israeli cancer research. [Cancer Research Institute] Press Release

Cancer Research UK and Biotecnol to Trial New Immuno-Oncology Treatment for Advanced Tumors

An experimental immuno-oncology treatment will move into early phase clinical trials for patients with advanced solid tumors, including lung cancers, under a collaboration agreement between Cancer Research UK and Biotecnol Limited. [Cancer Research UK] Press Release

CRISPR Patent Battle in Europe Takes a ‘Wild’ Twist with Surprising Player

MilliporeSigma, a subsidiary of pharmaceutical giant Merck KGaA of Darmstadt, Germany, has become a new major player in the complicated European patent battles over CRISPR, the revolutionary genome-editing tool. [ScienceInsider] Editorial

Thousands across India March in Support of Science

Thousands of scientists, university students and science enthusiasts gathered in dozens of Indian cities to march in support of science — lamenting their country’s low levels of funding for research, and complaining about government promotion of ‘unscientific ideas’. [Nature News] Editorial

FDA Cracks Down on Pioneering Doctor Who Created a Three-Parent Baby

The New York-based doctor who helped a couple have a child using DNA from three people has been told by the U.S. FDA that he can’t go ahead with clinical trials meant to test the technique. [MIT Technology Review] Editorial

NEW Gordon Research Conferences: Mammary Gland Biology
May 27-June 1, 2018
Barga, Italy

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Training Fellow – Breast Cancer Research (Institute of Cancer Research)

NEW Clinician Investigator – Breast Cancer Research (Mayo Clinic)

NEW Research Fellows – Cancer Research (National University of Singapore)

NEW Multiple Positions – Cancer Research (National University of Singapore)

Postdoctoral Position – Breast Cancer Research (Massachusetts General Hospital Cancer Center)

Canada Research Chair – Tumor Biology (University of Manitoba)

Higher Scientific Officer – Breast Cancer Research (Institute of Cancer Research)

PhD Student – Breast Cancer Biology (VIB-KULeuven Center for Cancer Biology)

Associate Medical Director/Medical Director – Breast Cancer (Genentech, Inc.)

RCSI Funded PhD – Cancer Systems Biology/Bioinformatics (Royal College of Surgeons in Ireland)

Postdoctoral Fellow – Cancer Research (University of Texas Health Science Center at San Antonio)

Postdoctoral Fellow – Cancer Genomics (University of Texas Health Science Center at Houston)

Postdoctoral Research Position – Experimental Oncology (KTH Royal Institute of Technology)

Postdoctoral Positions – Breast Cancer (Northwestern University – Feinberg School of Medicine)

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