Mammary Cell News 9.35 September 7, 2017 | |
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TOP STORYThis neoadjuvant Phase II trial was conducted to test the hypothesis that adding MK-2206 to anastrozole induces pathologic complete response in PIK3CA mutant estrogen receptor positive ER+ breast cancer. [Clin Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHResearchers identified a mechanism, unique to breast cancer cells, whereby cystathionine β-synthase (CBS) promotes elevated ratio of reduced to oxidized glutathione (GSH/GSSG). Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2) and processes downstream of Nrf2 that promoted GSH synthesis and regeneration of GSH from GSSG. [J Med Chem] Abstract A novel class of benzocoumarin-stilbene hybrid molecules were synthesized and evaluated for their antiproliferative activity against various cancer cell lines followed by in vivo antitumor activity in a mouse model of cancer. The most promising molecule among the series, i.e. compound (E)-4-(3,5-dimethoxystyryl)-2H-benzo[h]chromen-2-one, showed maximum antiproliferative activity in breast cancer cell lines (MDA-MB-231 and 4T1) and decreased the tumor size in the in vivo 4T1 cell-induced orthotopic syngeneic mouse breast cancer model. [Sci Rep] Full Article The efficacy of two front-line chemotherapeutic agents are described within three distinct in vitro models employing the triple-negative basal breast cancer cell line MDA-MB-231 and the luminal breast cancer cell line MCF7: a) a 3D collagen embedded multicellular spheroid tumor model, which reflects the architecture and cellular heterogeneity of tumors in vivo; b) a 3D collagen model with a single cell-type diffusely embedded; and c) a 2D monolayer. [Sci Rep] Full Article BRCA1 Regulation on β-hCG: A Mechanism for Tumorigenicity in BRCA1 Defective Breast Cancer Scientists identified that human chorionic gonadotropin β (β-hCG) expression is linked to BRCA1 status and its overexpression is seen in BRCA1 mutated breast cancer cells, BRCA1 conditional knockout mouse breast cancer tissues and BRCA1 floxed basal cell carcinoma tissues. [Oncogenesis] Full Article FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells Investigators present that, in the presence of tamoxifen, fibroblast growth factors (FGFs) promoted breast cancer cell growth with the strongest effect being produced by FGF7. FGFR2 was identified as a mediator of FGF7 action and the FGFR2-induced signaling was found to underlie cancer-associated fibroblasts-dependent resistance to tamoxifen. [Neoplasia] Full Article The authors report on the finding that stable knockdown of vitamin D receptor expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induced cell apoptosis and inhibited cell proliferation in vitro. [Bone Res] Full Article A TP73-AS1/MiR-200a/ZEB1 Regulating Loop Promotes Breast Cancer Cell Invasion and Migration Researchers evaluated the effect of TP73-AS1 in breast cancer cell invasion and migration, and further demonstrated the direct binding between TP73-AS1 and miR-200a, between miR-200a and 3’UTR of ZEB1, an essential metastasis-related transcription factor. [J Cell Biochem] Abstract Scientists demonstrated that phospholipase C (PLC-β2) induces the conversion of CD133high to CD133low cells, explored its possible role in down-modulating the expression of both CD133 and EpCAM and, ultimately, in reducing the number of triple negative breast cancer cells with a stem-like phenotype. [BMC Cancer] Full Article Human pre-adipocytes and HER2+ breast cancer cells were grown on tannic acid (TA)-crosslinked collagen type I beads. Cell attachment, growth, and proliferation of the cells result in remodeling of the collagen matrix and release of the crosslinking TA. [J Biomed Mater Res A] Abstract CLINICAL RESEARCHInvestigators determined if imaging with (89)Zr-trastuzumab, a human epidermal growth factor receptor 2 (HER2)-targeting PET tracer, could detect HER2-positive metastases in patients with HER2-negative primary breast cancer. [Clin Nucl Med] Abstract Scientists investigated progesterone receptor (PgR) expression as predictive factor for response to neoadjuvant therapy and long-term outcome. Estrogen receptor-positive/PgR-negative breast carcinomas were associated with higher response but also worse long-term outcome after neoadjuvant therapy. [Breast Cancer Res Treat] Abstract | |
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REVIEWSClassification cannot be performed based on traditional approaches such as segregation analyses, including for many missense variants, which are therefore referred to as variants of uncertain significance (VUS). Functional assays provide an important alternative for classification of BRCA1 and BRCA2 VUS. [J Med Genet] Abstract Circulating MicroRNAs in Breast Cancer: Novel Diagnostic and Prognostic Biomarkers The authors provide current state-of-the-art of miRNA biogenesis, function and discuss the advantages, limitations, as well as pitfalls of using circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management. [Cell Death Dis] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSStudy in Early Stage Breast Cancer Shows that Even Small Tumors Can Be Aggressive Even small tumors can be aggressive, according to a study in patients with early stage breast cancer that will be presented. Researchers found that nearly one in four small tumors were aggressive and patients benefited from chemotherapy. [Press release from the European Society for Medical Oncology discussing research to be presented at at the European Society for Medical Oncology (ESMO) 2017 Congress, Madrid] Press Release | Press Release 2 | |
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INDUSTRY NEWSLasker Prizes Recognize Work on Cell Growth, Cancer Prevention, and Reproductive Care The Albert and Mary Lasker Foundation announced its three annual prizes, each of which comes with a $250,000 award. Regarded as the United States’s most prestigious biomedical research awards, the Laskers often precede a Nobel Prize in Physiology or Medicine: Eighty-seven Lasker laureates have gone on to win a Nobel. [ScienceInsider] Editorial | Press Release H3 Biomedicine Announces First Patient Dosed with H3B-6545 in Phase I Study in Breast Cancer H3 Biomedicine Inc. announced dose administration for the first patient in a Phase I, open-label, dose-escalation and expansion study of single agent H3B-6545, an orally bioavailable, potent and selective small molecule antagonist of wild-type and mutant estrogen receptor (ERα). Preclinical data indicates H3B-6545 inhibits the growth of cell line and patient-derived xenograft models of wild-type and mutant ERα. [H3 Biomedicine Inc.] Press Release Lumicell, Inc. announced the initiation of clinical studies in breast cancer and prostate cancer with its LUM System. The newly-initiated breast cancer study builds on previous clinical trials in breast cancer patients with the LUM System, and is a pivotal study in breast cancer following an initial training period with surgeons. [Lumicell, Inc.] Press Release Delphinus Medical Technologies, Inc. announced that the SoftVue Discover Breast Ultrasound Prospective Case Collection project has launched, enrolling the first patient. Information gathered from the project will compare SoftVue imaging to digital mammography to determine the effectiveness of detecting additional cancers with SoftVue that are not seen with mammography alone, particularly in women with dense breast tissue. [Delphinus Medical Technologies, Inc.] Press Release | |
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POLICY NEWSUnited Kingdom Wants Cozy Science Ties with Europe after Brexit The United Kingdom government released a long-awaited position paper on the future of scientific collaborations with the European Union (EU) after Brexit. Its overarching goal is “a more ambitious and close partnership with the EU than any yet agreed between the EU and a non-EU country. [ScienceInsider] Editorial Senate Spending Panel Approves $2 Billion Raise for NIH in 2018 A Senate subcommittee approved a $2 billion raise, to $36.1 billion, for the National Institutes of Health (NIH) in the 2018 fiscal year. To the relief of research universities, the Senate draft spending bill would also block a Trump proposal to slash NIH payments to cover the overhead costs of research. [ScienceInsider] Editorial Researchers Thought Peace in Colombia Would Mean More Science Funding. They Were Wrong Wearing lab coats and hoisting placards with slogans such as “A country without science is a country without a future,” hundreds of scientists poured into plazas in cities across Colombia. Their beef: a proposed 42% cut to the 2018 budget of Colciencias, the nation’s science ministry in Bogotá, which doles out research grants and supports graduate students. [ScienceInsider] Editorial
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EVENTSNEW UK Interdisciplinary Breast Cancer Symposium 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Triple Negative Breast Cancer (University of Cambridge) Postdoctoral Position – Mammary Gland Stem Cells (Université Libre de Bruxelles) Postdoctoral Training Fellows – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Position – Mammary Tumors (Cancer Research UK Beatson Institute) Clinician Investigator – Breast Cancer Research (Mayo Clinic) Research Fellows – Cancer Research (National University of Singapore) Multiple Positions – Cancer Research (National University of Singapore) Postdoctoral Position – Breast Cancer Research (Massachusetts General Hospital Cancer Center) PhD Student – Breast Cancer Biology (VIB-KULeuven Center for Cancer Biology) Associate Medical Director/Medical Director – Breast Cancer (Genentech, Inc.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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