Mammary Cell News Volume 9.43 | Nov 2 2017

TOP STORY

A Vimentin Binding Small Molecule Leads to Mitotic Disruption in Mesenchymal Cancers

Researchers identified a small molecule, FiVe1, which selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells and soft tissue sarcomas of diverse histological subtypes. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

Coexpression of NOS2 and COX2 Accelerates Tumor Growth and Reduces Survival in Estrogen Receptor-Negative Breast Cancer

Scientists found that the key products of nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2), NO and prostaglandin E2 (PGE2), respectively, promoted feed-forward NOS2/COX2 crosstalk in both MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cell lines in which NO induced COX2 and PGE2 induced NOS2 proteins. [Proc Natl Acad Sci USA] Full Article

Dual mTOR Kinases MLN0128 Inhibitor Sensitizes HR⁺/HER2⁺ Breast Cancer Patient-Derived Xenografts to Trastuzumab or Fulvestrant

Compared to the standard trastuzumab treatment, investigators demonstrated alternative therapeutic strategies against HR⁺/HER2⁺ tumors through establishment of two patient-derived xenografts coupling with integrative omics analyses and in vivo drug efficacy examination. [Clin Cancer Res] Abstract | Full Article

Transcription Factor c-Myb Inhibits Breast Cancer Lung Metastasis by Suppression of Tumor Cell Seeding

Researchers showed that increased c-Myb expression in breast cancer cells inhibited spontaneous lung metastasis through impaired tumor cell extravasation. They identified a specific inflammatory signature, including Ccl2 chemokine, that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. [Oncogene] Abstract

ZEB1-Repressed MicroRNAs Inhibit Autocrine Signaling that Promotes Vascular Mimicry of Breast Cancer Cells

Scientists showed that serum withdrawal induces mesenchymal breast cancer cells to undergo vascular mimicry and that knockdown of the epithelial-to-mesenchymal transition regulator, Zinc finger E-box binding homeobox 1 (ZEB1), or overexpression of the ZEB1-repressed miRNAs, miR-200c, miR-183, miR-96 and miR-182 inhibits this process. [Oncogene] Full Article

Flubendazole Overcomes Trastuzumab Resistance by Targeting Cancer Stem-Like Properties and HER2 Signaling in HER2-Positive Breast Cancer

The authors investigate the effect of flubendazole (FLU) on apoptosis, HER2/Akt signaling, breast cancer stem cell-like properties and trastuzumab resistance in HER2-positive breast cancer cells. FLU treatment induced apoptosis, associated with a significant downregulation of truncated p95HER2, phospho-HER2, phospho-HER3 and phospho-Akt levels, as well as suppression of HER2/HER3 hetero-dimerization in both trastuzumab-sensitive and –resistant lines. [Cancer Lett] Abstract

Eugenol Potentiates Cisplatin Anti-Cancer Activity through Inhibition of ALDH-Positive Breast Cancer Stem Cells and the NF-κB Signaling Pathway

Adding eugenol to cisplatin potentiated the inhibition of breast cancer stem cells by inhibiting ALDH enzyme activity and ALDH-positive tumor initiating cells. Researchers provided evidence that eugenol potentiates cisplatin inhibition of the NF-κB signaling pathway. [Mol Carcinog] Abstract

A High Throughput Method to Study the Physiology of E2:ERα Signaling in Breast Cancer Cells

Scientists performed a Western blotting-based screen to identify novel pathways affecting estrogen receptor α (ERα) intracellular levels and breast cancer cell proliferation. [J Cell Physiol] Abstract

miR-1296-5p Decreases ERBB2 Expression to Inhibit the Cell Proliferation in ERBB2-Positive Breast Cancer

Investigators suggest that miR-1296-5p is involved in the regulation of proliferation in breast cancer cells via targeting ERBB2/mTORC1 signaling pathway. [Cancer Cell Int] Full Article

PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer

The authors provide an overview of the treatment options for basal-like triple-negative breast cancer, including poly (ADP-ribose) polymerase (PARP) inhibitors, and focuses on the pharmacotherapeutic options in these patients. [Clin Pharmacokinet] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Natera Chosen for Longitudinal Circulating Tumor DNA Study in Breast Cancer

Natera, Inc. has entered into a research collaboration with Imperial College London and the University of Leicester, U.K., to leverage the company’s Signatera^™ personalized circulating tumor DNA technology to evaluate retrospectively the use of ctDNA to detect disease recurrence in women breast cancer patients. [Natera, Inc.] Press Release

Xia Awarded Komen Grant for Breast Cancer Imaging Research

Jun Xia, PhD, assistant professor of biomedical engineering, has been awarded a $450,000 grant that will help improve screening for women with dense breast tissue. [University at Buffalo] Press Release

FDA Approves the Roll-Over Combination Study with Checkpoint Inhibitor Immunotherapies to Allow Continued Access to BriaVax^™ in Patients with Advanced Breast Cancer

BriaCell Therapeutics Corp. announced that the FDA has approved the roll-over combination study of BriaVax^™ with pembrolizumab or ipilimumab for patients previously treated with BriaVax^™ from the ongoing Phase I/IIa Clinical Trial in Advanced Breast Cancer. [BriaCell Therapeutics Corp.] Press Release

Dr. Nancy Davidson Receives Jill Rose Award from Breast Cancer Research Foundation

Breast cancer researcher Dr. Nancy Davidson, senior vice president and director of the Clinical Research Division at Fred Hutchinson Cancer Research Center, has received the Jill Rose Award from the Breast Cancer Research Foundation. [Fred Hutchinson Cancer Research Center] Press Release

Susan Bulkeley Butler Award Presented at International Breast Cancer Prevention Symposium

The Susan Bulkeley Butler Leadership Excellence Award was presented to the president of Uruguay and an oncologist at Indiana University during the International Breast Cancer Prevention Symposium, co-organized by the Purdue University Center for Cancer Research in partnership with the International Breast Cancer and Nutrition collaboration. [Purdue University] Press Release

Pay for US Postdocs Varies Wildly by Institution

The salary data are incomplete and — in some cases — appear to be incorrect. Some researchers are listed as earning nothing, and another study underway suggests a higher overall rate of pay for US postdocs. But the latest analysis underscores the challenges of getting basic information about an under-recognized and misunderstood segment of the academic workforce. [Nature News] Editorial

Leading Western Publisher Bows to Chinese Censorship

Springer Nature, whose publications include Nature and Scientific American, acknowledged that at the government’s request, it had removed articles from its mainland site that touch on topics the ruling Communist Party considers sensitive, including Taiwan, Tibet, human rights and elite politics. [The New York Times] Editorial

Spanish Government Takes Control of Catalonian Universities

The Spanish government has taken over responsibility for higher education and research in Catalonia, following the region’s unilateral declaration of independence. It will retain control of spending on research centres and universities, which the League of European Research Universities says threatens institutional autonomy. [Nature News] Editorial

NEW International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting
June 20-23, 2018
Melbourne, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Training Fellow – Breast Cancer Organoids (Institute of Cancer Research)

NEW Executive Director – Breast Cancer Research (Indiana University School of Medicine)

NEW Cancer Bioinformatician – Breast Cancer Research (Institute of Cancer Research)

PhD Studentships – Cancer Research (University of Cambridge)

Postdoctoral Positions – Breast Cancer (Northwestern University- Feinberg School of Medicine)

Physician Scientist – Translational Research in Breast Cancers (University of New Mexico)

Postdoctoral Fellow – Translational Research in Breast Cancer (University of Texas Southwestern Medical Center)

Postdoctoral Training Fellows – Breast Cancer Research (Institute of Cancer Research)

Postdoctoral Positions – Interdisciplinary Translational Research (University of Texas Health Science Center at San Antonio)

Postdoctoral Fellowship – Breast Cancer Research (Geisel School of Medicine at Dartmouth)

Assistant Professor – Cancer Biology (Perelman School of Medicine)

Assistant Professor – Cancer Research (University of Minnesota)

Postdoctoral Position – Cancer Metabolism (University of Louvain)

Postdoctoral Position – Transcriptomics and Cancer Epigenetics (Universität Basel)

Postdoctoral Opportunities – Cancer Research (Albert Einstein College of Medicine in New York)

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