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Pulmonary Cell News| Mammary Cell News 9.44 November 9, 2017 | |
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TOP STORYProof of Region-Specific Multipotent Progenitors in Human Breast Epithelia Researchers showed that stem-like activity in serial passage culture and in vivo breast morphogenesis relies on the preservation of a myoepithelial phenotype. By enrichment for region-specific progenitors, they identified bipotent and multipotent progenitors in ducts and terminal duct lobular units, respectively. [Proc Natl Acad Sci USA] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Puberty is characterized by dynamic tissue remodeling in the mammary gland involving ductal elongation, resolution into the mature epithelial bilayer, and lumen formation. To decipher the cellular mechanisms underlying these processes, investigators studied the fate of putative stem cells, termed cap cells, present in terminal end buds of pubertal mice. [Dev Cell] Abstract | Graphical Abstract Glycolysis Gatekeeper PDK1 Reprograms Breast Cancer Stem Cells under Hypoxia Scientists showed that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells, whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-related transcriptional factor expression, and inhibits sphere-formation ability and tumor growth. [Oncogene] Abstract Researchers showed that calycosin inhibited the proliferation of both estrogen receptor-negative and estrogen receptor-positive breast cancer cells and that these inhibitory effects were associated with the up-regulation of the long non-coding RNA WDR7-7. They demonstrated that the expression of WDR7-7 was reduced in breast cancer cell lines and that the overexpression of WDR7-7 inhibits growth through a mechanism that involves G-protein coupled estrogen receptor 30 (GPR30). [J Exp Clin Cancer Res] Full Article Novel aptamers were successfully selected and characterized against mammaglobin B and mammaglobin A proteins using a hybrid SELEX approach. The potential use of the selected aptamers in breast circulating tumor cell detection was studied using spiked breast cancer cells in whole blood lysate. [Sci Rep] Full Article The authors identified the Ephrin type-A receptor 4 (EPHA4) as a novel target of transforming growth factor-beta (TGFβ) in breast cancer. They showed that TGFβ induction of EPHA4 gene expression is specific to basal-like tumors and is required for TGFβ-mediated cell migration. [Sci Rep] Full Article Simultaneous inhibition of epidermal growth factor receptor and insulin-like growth factor 1 receptor in cisplatin-resistant triple negative breast cancer cell lines was synergistic regarding inhibition of proliferation and induction of apoptosis. Co-treatment with targeted therapies, NVP-BEZ235 or with a combination of NVP-AEW541 and lapatinib, restored cisplatin sensitivity. [BMC Cancer] Full Article The cytotoxic effect of sodium butyrate (NaBu) on the growth of breast cancer cells and normal breast cells was determined using MTT assay. NaBu induced a dose and time-dependent cell toxicity in breast cancer cells which was related to the cell cycle arrest and induction of apoptosis. [Lipids Health Dis] Full Article Scientists explored the utility of a clinical-stage monoclonal antibody that neutralizes IL-8 (HuMax-IL8) as a potential therapeutic option for triple negative breast cancer (TNBC). HuMax-IL8 was shown to revert mesenchymalization in claudin-low TNBC models both in vitro and in vivo as well as to significantly decrease the recruitment of polymorphonuclear myeloid-derived suppressor cells at the tumor site, an effect substantiated when used in combination with docetaxel. [JCI Insight] Full Article | |
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REVIEWSRecent Advances in Comprehending the Signaling Pathways Involved in the Progression of Breast Cancer The authors describe recent advances in the comprehension of signaling pathways involved in breast cancer progression. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSPharmaMar and Boryung Pharm Sign a Licensing Agreement for Zepsyre in Korea PharmaMar announced a licensing agreement with Boryung Pharm to commercialize the marine-derived anticancer drug Zepsyre®, if approved, in South Korea. [PharmaMar] Press Release Novartis announced positive topline results from the global MONALEESA-7 trial, the second Phase III trial of Kisqali® in advanced or metastatic breast cancer. The MONALEESA-7 trial met its primary endpoint of progression-free survival in premenopausal women with hormone-receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2–) advanced breast cancer. [Novartis] Press Release | |
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POLICY NEWSUK Government Appoints Next Chief Scientific Adviser Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial Indian Scientists Urged to Speak Out about Pseudoscience A leading Indian science-advocacy group is urging the country’s researchers to speak out against pseudoscience, which it fears has gained a foothold in the past few years, partly through support from some agencies of the Indian government. [Nature News] Editorial Court Demands that Search Engines and Internet Service Providers Block Sci-Hub The American Chemical Society (ACS) has won a lawsuit against Sci-Hub, a website providing illicit free access to millions of paywalled scientific papers. ACS had alleged copyright infringement, trademark counterfeiting and trademark infringement; a district court in Virginia ruled that Sci-Hub should pay the ACS $4.8 million in damages after Sci-Hub representatives failed to attend court. [ScienceInsider] Editorial
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EVENTSNEW International Istanbul Breast Cancer Conference – BREASTANBUL 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Scientist/Fellow – Breast Cancer (Columbia University) Postdoctoral Training Fellow – Breast Cancer Organoids (Institute of Cancer Research) Executive Director – Breast Cancer Research (Indiana University School of Medicine) Cancer Bioinformatician – Breast Cancer Research (Institute of Cancer Research) PhD Studentships – Cancer Research (University of Cambridge) Postdoctoral Positions – Breast Cancer (Northwestern University- Feinberg School of Medicine) Physician Scientist – Translational Research in Breast Cancers (University of New Mexico) Postdoctoral Training Fellows – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Fellowship – Breast Cancer Research (Geisel School of Medicine at Dartmouth) Assistant Professor – Cancer Biology (Perelman School of Medicine) Assistant Professor – Cancer Research (University of Minnesota) Postdoctoral Position – Transcriptomics and Cancer Epigenetics (Universität Basel) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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