Mammary Cell News 9.47 November 30, 2017 | |
| |
TOP STORYNew Breast Cell Types Discovered by Multidisciplinary Research Team A joint effort by breast cancer researchers and bioinformaticians has provided new insights into the molecular changes that drive breast development. The research team compared genes expressed in single cells in the mammary gland to understand the broad molecular changes that occur during development. [Press release from The Walter and Eliza Hall Institute of Medical Research discussing online prepublication in Nat Commun] Press Release | Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)The HSF1–PARP13–PARP1 Complex Facilitates DNA Repair and Promotes Mammary Tumorigenesis The authors showed that heat shock transcription factor 1 (HSF1) recruits Poly(ADP-ribose) polymerase 1 (PARP1) through the scaffold protein PARP13. In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociated from HSF1–PARP13, and redistributed to DNA lesions and DNA damage-inducible gene loci. [Nat Commun] Full Article To investigate t-Darpp’s mechanism of action, scientists evaluated t-Darpp:IGF-1R complexes by co-immunoprecipitation and proximity ligation assays. They used pathway-specific inhibitors to study the dependence of t-Darpp effects on IGF-1R signaling and used siRNA knockdown to determine if glucose reliance in trastuzumab-resistant SK-BR-3 cells was mediated by t-Darpp. [Clin Cancer Res] Abstract Investigators evaluated the utility of combining circulating tumor cells and circulating tumor DNA to predict prognosis in metastatic breast cancer. [Clin Cancer Res] Abstract | Full Article The authors showed how the efficacy of PARP inhibitors in triple-negative breast cancers (TNBC) can be expanded by targeting MYC-induced oncogenic addiction. In BRCA-mutant/sporadic TNBC patients, amplification of the MYC gene was correlated with increased expression of the homologous DNA recombination enzyme RAD51 and tumors overexpressing both genes were associated with worse overall survival. [Cancer Res] Abstract Mammosphere formation, flow cytometry, soft agar colony and tumor formation assays were performed to evaluate the effects of VEGF-A/Neuropilin 1 (NRP-1) on breast cancer stemness. Overexpression of VEGF-A or NRP-1 conferred cancer stem cell (CSC)-related traits in MCF-7 cells, while knockdown of VEGF-A or NRP-1 reduced CSC-related traits in MDA-MB-231 cells in vitro and in vivo. [Cell Physiol Biochem] Full Article A Distinct Endocytic Mechanism of Functionalized-Silica Nanoparticles in Breast Cancer Stem Cells Researchers demonstrated that the uptake of silica nanoparticles (SiNPs), particularly amino-functionalized SiNPs, in MCF-7 cells is strongly affected by the actin depolymerization, whereas breast cancer stem cells more strongly inhibit the amino-functionalized SiNP uptake after the scavenger receptor disruption. [Sci Rep] Full Article Investigators characterized the transcriptional response of MDA-MB-231 and MDA-MB-468 breast cancer cells to retinaldehyde dehydrogenase 1A3 (ALDH1A3) and all-trans retinoic acid (atRA). They demonstrated limited overlap between ALDH1A3-induced gene expression and atRA-induced gene expression in both cell lines, suggesting that the function of ALDH1A3 in breast cancer progression extends beyond its role as a retinaldehyde dehydrogenase. [Sci Rep] Full Article Estrogen Induces c-Kit and An Aggressive Phenotype in a Model of Invasive Lobular Breast Cancer Scientists examined BCK4 xenograft tumors from mice supplemented with or without estrogen using gene expression arrays. To elucidate genes regulated in vitro by estrogen in BCK4 cells, they performed expression profiling using Illumina arrays of the BCK4 cell line, treated with or without estrogen in vitro. [Oncogenesis] Full Article The LPI/GPR55 Axis Enhances Human Breast Cancer Cell Migration via HBXIP and p-MLC Signaling Researchers showed that G protein-coupled receptor 55 (GPR55) expression levels in 38 metastatic lymph nodes of breast cancer patients were profoundly elevated, and were positively associated in human breast cancer cells with their migratory ability. [Acta Pharmacol Sin] Abstract miR205 Inhibits Stem Cell Renewal in SUM159PT Breast Cancer Cells Investigators analyzed the impact of miR205 ectopic expression in the initial tumorigenic processes of SUM159PT, a triple negative breast cancer cell line with low endogenous levels of miR205. In SUM159PT, miR205 inhibited expression of its targets VEGFA, ErbB3, Zeb1, Fyn and Lyn A/B; it reduced cell proliferation, and Myc/cyclin D1 levels, while increased p27kip1 expression. [PLoS One] Full Article | |
| |
REVIEWSThe Dual Regulatory Role of MiR-181a in Breast Cancer The authors summarize the current literature demonstrating established links between miR-181a and human breast cancer with a focus on recently identified mechanisms of action. This review also to explores the potential of miR-181a as a diagnostic and/or prognostic biomarker for breast cancer and discusses the contradicting data regarding its targeting therapeutics and the associated challenges. [Cell Physiol Biochem] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
| |
SCIENCE NEWSAgendia, Inc. announced the presentation of extensive new data highlighting the value of its MammaPrint® 70-Gene Breast Cancer Risk-of-Recurrence Test and BluePrint® Breast Cancer Molecular Subtyping Test. A total of eleven posters and discussions are being presented. [Press release from Agendia, Inc. discussing research to be presented at 40th San Antonio Breast Cancer Symposium (SABCS), San Antonio] Press Release Merck announced that new and updated data from six abstracts investigating KEYTRUDA®, the company’s anti-PD-1 therapy, as both monotherapy and combination therapy, across a range of difficult-to-treat breast cancers, will be presented. [Press release from Merck Sharp & Dohme Corp. discussing research to be presented at 40th San Antonio Breast Cancer Symposium (SABCS), San Antonio] Press Release Genomic Health, Inc. announced that it will present ten Oncotype DX® studies. [Press release from Genomic Health, Inc. discussing research to be presented at 40th San Antonio Breast Cancer Symposium (SABCS), San Antonio] Press Release | |
| |
INDUSTRY NEWSResearchers at Albert Einstein College of Medicine, part of Montefiore, and Hackensack Meridian Health John Theurer Cancer Center at Hackensack University Medical Center have secured a five-year, $6.4 million grant from the National Institutes of Health (NIH) to identify biomarkers that can predict which women with pre-cancerous tissue in their breast will develop invasive breast cancer. [Albert Einstein College of Medicine] Press Release Epic Sciences Launches Metastatic Breast Cancer Circulating Tumor Cell Panel Epic Sciences, Inc. announced the release of its breast cancer single-cell profiling panel. The Epic breast cancer panel is the most comprehensive breast cancer biomarker panel available for characterization of circulating tumor cells within a blood sample. [Epic Sciences, Inc.] Press Release Mylan N.V. and Biocon Ltd. announced that the European Medicines Agency has accepted for review Mylan’s Marketing Authorization Applications for proposed biosimilar trastuzumab and proposed biosimilar pegfilgrastim. [Mylan N.V.] Press Release | |
| |
POLICY NEWSHealth Agency Reveals Scourge of Fake Drugs in Developing World One in ten medicines in developing countries is fake or substandard, data from the World Health Organization suggest. Malaria drugs and antibiotics are among the most commonly reported, the agency found. But the problem extends to a variety of medications, including those for cancer, heart disease and HIV, as well as contraceptives and painkillers. [Nature News] Editorial China to Roll Back Regulations for Traditional Medicine Despite Safety Concerns Support for traditional medicine in China goes right to the top. President Xi Jinping has called this type of medicine a “gem” of the country’s scientific heritage and promised to give alternative therapies and Western drugs equal government support. The country is taking dramatic steps to promote these cures even as researchers raise concerns about such treatments. [Nature News] Editorial Zimbabwe’s Researchers Hope Political Change Will Revitalize Science Academics are optimistic that the end of Robert Mugabe’s authoritarian rule could boost research and international collaboration. [Nature News] Editorial United Kingdom Relies on Science to Revive Flagging Economy The United Kingdom has laid out how it will pour money into research to boost its economy — including cash for artificial intelligence and other high-tech industries — as the country prepares to leave the European Union in 2019. [Nature News] Editorial
| |
EVENTSNEW SYStem – Symposium for the Next Generation of Stem Cell Researchers Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Associate – Breast Cancer Research (University of Miami) NEW Postdoctoral Associate – Melanoma and Breast Cancer Research (University of Miami) Cancer Bioinformatician – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Research Scientist/Fellow – Breast Cancer (Columbia University) Executive Director – Breast Cancer Research (Indiana University School of Medicine) Postdoctoral Positions – Breast Cancer (Northwestern University – Feinberg School of Medicine) Physician Scientist – Translational Research in Breast Cancers (University of New Mexico) Postdoctoral Fellowship – Breast Cancer Research (Geisel School of Medicine at Dartmouth) Assistant Professor – Cancer Biology (Perelman School of Medicine) Postdoctoral Position – Transcriptomics and Cancer Epigenetics (Universität Basel) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mammary Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|