Mesenchymal Cell News Volume 10.16 | Apr 24 2018

TOP STORY

Biomaterial Surface Energy-Driven Ligand Assembly Strongly Regulates Stem Cell Mechanosensitivity and Fate on Very Soft Substrates

Scientists revealed that surface energy-driven supramolecular ligand assembly can regulate MSC sensing of substrate mechanical compliance and subsequent cell fate. [Proc Natl Acad Sci USA] Full Article

(Ranked by impact factor of the journal)

IN VITRO

The Deubiquitinating Enzyme UCHL1 Negatively Regulates the Immunosuppressive Capacity and Survival of Multipotent Mesenchymal Stromal Cells

Researchers identified that the deubiquitinating enzyme ubiquitin C-terminal hydrolase 1 (UCHL1) was upregulated in MSCs upon stimulation of proinflammatory cytokines IFN-γ plus TNF-α. [Cell Death Dis] Full Article

Long Noncoding RNA TUG1 Facilitates Osteogenic Differentiation of Periodontal Ligament Stem Cells via Interacting with Lin28A

Scientists found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present long noncoding RNA was significantly upregulated in osteogenically induced periodontal ligament stem cells compared to their undifferentiated counterparts. [Cell Death Dis] Full Article

Mutual Inhibition between HDAC9 and miR-17 Regulates Osteogenesis of Human Periodontal Ligament Stem Cells in Inflammatory Conditions

Investigators report that histone deacetylase (HDAC)9 was the most affected HDAC family member under inflammatory conditions in periodontal ligament stromal cells (PDLSCs). HDAC9 impaired osteogenic differentiation capacity of PDLSCs under inflammatory conditions. [Cell Death Dis] Full Article

STAT-3 Regulation of CXCR4 Is Necessary for the Prenylflavonoid Icaritin to Enhance Mesenchymal Stem Cell Proliferation, Migration and Osteogenic Differentiation

Using an in vitro cell culture model, researchers investigated the benefits of icaritin treatment in enhancing MSC proliferation, migration and osteogenic differentiation, and provided novel data to describe its mechanism of action. [Biochim Biophys Acta] Abstract

Combining Electrical Stimulation and Tissue Engineering to Treat Large Bone Defects in a Rat Model

The authors performed in vitro experiments and demonstrated that exposing MSCs + scaffold to electrical stimulation for three weeks resulted in significant increases in osteogenic differentiation. [Sci Rep] Full Article

Long Noncoding RNA H19 Upregulates Vascular Endothelial Growth Factor A to Enhance Mesenchymal Stem Cells Survival and Angiogenic Capacity by Inhibiting miR-199a-5p

Overexpression of long noncoding RNA H19 improved survival and angiogenic capacity of MSCs under both normoxia and hypoxia/serum deprivation conditions, whereas its knockdown impaired cell viability and their angiogenic potential. [Stem Cell Res Ther] Full Article

-5p and -3p Strands of miR-145 and miR-140 during Mesenchymal Stem Cell Chondrogenic Differentiation

Investigators examined both -5p and -3p strands of two key miRNAs miR-140 and miR-145 that are known to be involved in the chondrogenic differentiation of MSCs. The gene expression profiles of several genes related to MSC chondrogenesis were compared with these miRNA profiles along the same timeline. [Tissue Eng Part A] Abstract

IN VIVO

A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells Associated with Enhanced Wound Healing

After injection of MSCs, which had been pretreated with the calcium-binding danger associated molecular pattern protein S100A8/A9 into murine full-thickness wounds, scientists observed a significant acceleration of healing even exceeding that of non-treated MSCs. [Sci Rep] Full Article

Transplantation of Adipose-Derived Mesenchymal Stem Cells Attenuates Pulmonary Fibrosis of Silicosis via Anti-Inflammatory and Anti-Apoptosis Effects in Rats

The authors investigated the anti-pulmonary fibrosis effects of the transplantation of adipose-derived (AD)-MSCs in rats in which lung fibrosis was induced by oral tracheal intubation with silica suspension. Treatment with AD-MSC transplantation led to a remissive effect on pulmonary fibrosis. [Stem Cell Res Ther] Full Article

Application of Mesenchymal Stem Cells to Enhance Non‐Union Bone Fracture Healing

A combination of adipose derived MSCs, cancellous bone graft, and chitosan hydrogel was applied to the in non‐union bone fracture and healing effects were evaluated. [J Biomed Mater Res A] Abstract

Challenges and Research Progress of the Use of Mesenchymal Stem Cells in the Treatment of Ischemic Stroke

Cerebral ischemic stroke (CIS) has become a hot issue in medical research because of the diversity of risk factors and the uncertainty of prognosis. Scientists discuss the progresses and some obstacles of using MSCs for the treatment of CIS. [Brain Dev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Merck KGaA, Darmstadt, Germany, Presents New Osteoarthritis Data

Merck KGaA announced that 16 abstracts, including two oral presentations, will be presented. [Press release from Merck KGaA discussing research to be presented at the Osteoarthritis Research Society International (OARSI) 2018 World Congress, Liverpool] Press Release

New Stem Cell Therapy May Transform Heart Failure Treatment

Clinical trial planning is underway at MedStar Heart & Vascular Institute to determine whether a novel stem cell therapy will improve heart function for patients with heart failure. MedStar Heart, in partnership with CardioCell, a subsidiary of Stemedica Cell Technologies, pioneered the use of stem cells in regenerative medicine. The trial will use CardioCell’s proprietary MSCs, manufactured by Stemedica. [Stemedica Cell Technologies, Inc.] Press Release

Cynata Therapeutics Completes Patent Application to Cover Cymerus^™ Stem Cell Technology in the Treatment of Side Effects Related to CAR-T Therapy

Cynata Therapeutics Limited announced that it has completed the filing of a patent application with IP Australia that would cover the therapeutic use of its Cymerus^™ stem cell technology in the treatment of adverse reactions associated with chimeric antigen receptor T-cell (CAR-T) immunotherapy. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

Scientists’ Early Grant Success Fuels Further Funding

Young researchers who narrowly miss out on postdoctoral grant struggle to compete with those who just qualify. [Nature News] Editorial

Speaking Science to Power

A statement released by 317 National Academy of Sciences members challenges the widespread dismissal of science and scientific understanding by the Trump administration. [Scientific American] Editorial

Salk Puts Cancer Scientist Inder Verma on Leave after Harassment Allegations, Announces Investigation

The Salk Institute for Biological Studies has placed prominent cancer and gene therapy scientist Inder Verma on administrative leave and launched an investigation into allegations against him. [ScienceInsider] Editorial

Dutch Universities, Journal Publishers Agree on Open-Access Deals

Despite some difficult negotiations, academic institutions in the Netherlands have been securing subscriptions that combine publishing and reading into one fee. [The Scientist] Editorial

NEW 11^th Annual Business of Regenerative Medicine: Innovation, Clinical Translation, and Entrepreneurship Symposium
July 17-18, 2018
Philadelphia, Pennsylvania, United States

NEW 7^th Annual International Symposium on Regenerative Rehabilitation
October 11-13, 2018
Seattle, Washington, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow/Senior Scientist – Aortic Aneurysm and Postnatal Bone Growth (Icahn School of Medicine at Mount Sinai)

Scientist – Stem Cell and Regenerative Biology (Moderna Therapeutics)

Assistant Professor – Regenerative Medicine (University of California, San Diego)

Postdoctoral Research Fellow – Musculoskeletal Tissue Regeneration (University of South Dakota)

Postdoctoral Fellow – Bone Biology (Cornell University)

Postdoctoral Positions – Bioengineering (George Washington University)

Postdoctoral Fellowship – Skeletal Stem Cell Biology (Johns Hopkins University)

Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois)

Postodoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories)

Postdoctoral Researcher – Cell Biology (University of Pennsylvania)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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