Mesenchymal Cell News Volume 10.17 | May 1 2018

TOP STORY

Histone Demethylase LSD1 Regulates Bone Mass by Controlling WNT7B and BMP2 Signaling in Osteoblasts

Knockdown of lysine-specific demethylase 1 (LSD1) promoted osteoblast differentiation of human MSCs in vitro and mice lacking LSD1 in MSCs displayed increased bone mass secondary to accelerated osteoblast differentiation. [Bone Res] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Immune System Augmentation via Humanization Using Stem/Progenitor Cells and Bioengineering in a Breast Cancer Model Study

Scientists developed an advanced humanized model with features of an organ bone by providing different bone tissue cellular compartments including pre‐osteoblasts, MSCs, endothelial and hematopoietic cells in an engineered microenvironment. [Int J Cancer] Abstract

Multilayered Coating of Titanium Implants Promotes Coupled Osteogenesis and Angiogenesis In Vitro and In Vivo

The authors used surface-modified titanium substrates with a multilayered structure composed of chitosan-catechol, gelatin and hydroxyapatite nanofibers, which were previously shown to improve osteogenesis, as a platform to investigate the interaction of osteogenesis and angiogenesis during bone healing. [Acta Biomater] Abstract | Graphical Abstract

Therapeutic Delivery Specifications Identified through Compartmental Analysis of a Mesenchymal Stromal Cell-Immune Reaction

Researchers conducted a systems level microenvironment approach to define compartmental features that can influence the delivery of MSCs’ immunomodulatory effect in vitro in a more quantitative manner than ever before. [Sci Rep] Full Article

GH Prevents Adipogenic Differentiation of Mesenchymal Stromal Stem Cells Derived from Human Trabecular Bone via Canonical Wnt Signaling

Using primary human MSCs isolated from trabecular bone, scientists assessed the possible effect of growth hormone (GH) on human MSC differentiation potential into adipocytes. [Bone] Full Article

IN VIVO

Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids

Transplanting runt-related transcription factor 2-transfected MSC spheroids into bone defects on rat femurs induced significantly faster bone regeneration compared with nontransfected MSC spheroids or genetically modified MSCs from conventional monolayer culture. [Mol Ther Methods Clin Dev] Full Article | Graphical Abstract

C-Met-Activated Mesenchymal Stem Cells Rescue Ischemic Damage via Interaction with Cellular Prion Protein

Transplantation of hypoxia-pre-exposed MSCs to the ischemic site increased anti-apoptosis and enhanced the survival and proliferation of transplanted MSCs in a murine hindlimb model, resulting in improved functional recovery of the ischemic tissue. [Cell Physiol Biochem] Full Article

3D Bio-Printed Scaffold-Free Nerve Constructs with Human Gingiva-Derived Mesenchymal Stem Cells Promote Rat Facial Nerve Regeneration

Investigators explored the potential use of human gingiva-derived MSCs as the only cellular component in 3D bio-printed scaffold-free neural constructs that were transplantable to bridge facial nerve defects in rats. [Sci Rep] Full Article

Mesenchymal Stem Cells Form 3D Clusters following Intraventricular Transplantation

The authors investigated the in vivo behavior of canine, human, and murine MSCs following intra-cerebroventricular transplantation. [J Mol Neurosci] Abstract

Limbal Niche Cells Are a Potent Resource of Adult Mesenchymal Progenitors

Limbal niche cells located in the limbal Palisades of Vogt are mesenchymal stem cells that reside next to limbal basal epithelial cells. Expanded limbal niche cells have the capability to undergo adipogenesis, chondrogenesis, osteogenesis and endogenesis in vitro, indicating that they are in fact a valuable resource of adult progenitors. [J Cell Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Mesenchymal Stem Cell-Seeded High-Density Collagen Gel for Annular Repair: In Vivo Sheep Study

Winner of the Stewart B. Dunsker, MD, Award, Ibrahim Hussain, MD, presented his research, Mesenchymal Stem Cell-Seeded High-density Collagen Gel for Annular Repair: In Vivo Sheep Study. [Press release from American Association of Neurological Surgeons (Newswise, Inc.) discussing research presented at the 2018 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting, New Orleans] Press Release

STEMCELL Technologies Announces $45 Million Government Funding for Advanced Manufacturing Facility

STEMCELL Technologies announced a $45 million joint funding agreement between the Governments of Canada and British Columbia to help the company build a state-of-the-art advanced manufacturing facility. [STEMCELL Technologies Inc.] Press Release

Amgen Receives Positive CHMP Opinion to Expand Use of Prolia^® (Denosumab) to Patients with Glucocorticoid-Induced Osteoporosis

Amgen announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion for the marketing authorization of Prolia^® for the treatment of bone loss associated with long-term systemic glucocorticoid therapy in adult patients at increased risk of fracture. [Amgen] Press Release

Altum Pharmaceuticals, Inc. Completes Acquisition of Lexi Pharma Inc, and Its Pipeline of Novel Therapies for Bone Disease and Oncology

Altum Pharmaceuticals Inc. announced that it has completed the acquisition of Lexi Pharma Inc. [Altum Pharmaceuticals Inc.] Press Release

Federal Appeals Court Hears CRISPR Patent Dispute

A federal appeals court heard arguments that the U.S. patent office made legal mistakes when reviewing its ruling on CRISPR, the genome editor. [ScienceInsider] Editorial

Harassment and Discrimination Allegations Roil a Top US Biomedical Institute

Allegations of sexual harassment and assault levelled against Inder Verma, a prominent cancer biologist at the Salk Institute for Biological Studies in La Jolla, California, cap a tumultuous ten months for the well-known research centre. [Nature News] Editorial

Science in North Korea: How Easing the Nuclear Stand-Off Might Bolster Research

The isolated nation publishes fewer than 100 scholarly articles a year — but as political tensions thaw, researchers hope for greater collaboration. [Nature News] Editorial

Disgraced Surgeon Is Still Publishing on Stem Cell Therapies

Paolo Macchiarini, an Italian surgeon, has been fired from two institutions and faces the retraction of many of his papers after findings of scientific misconduct and ethical lapses in his research—yet this hasn’t prevented him from publishing again in a peer-reviewed journal. [ScienceInsider] Editorial

NEW 23^rd Congress of European Hematology Association (EHA)
June 14-17, 2018
Stockholm, Sweden

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Cell Biology and Disease (European Molecular Biology Laboratory)

NEW Senior Lecturer – Cell Biology and Genetics (University of Chicago)

NEW Postdoctoral Position – Cell Biology (University of Houston)

NEW Review Scientists – Gene and Cell Therapy (Center for Biologics Evaluation and Research)

Postdoctoral Fellow/Senior Scientist – Aortic Aneurysm and Postnatal Bone Growth (Icahn School of Medicine at Mount Sinai)

Scientist – Stem Cell and Regenerative Biology (Moderna Therapeutics)

Assistant Professor – Regenerative Medicine (University of California, San Diego)

Postdoctoral Research Fellow – Musculoskeletal Tissue Regeneration (University of South Dakota)

Postdoctoral Fellow – Bone Biology (Cornell University)

Postdoctoral Positions – Bioengineering (George Washington University)

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