Mesenchymal Cell News Volume 10.23 | Jun 12 2018

TOP STORY

Exosome-Mediated Transfer of lncRUNX2-AS1 from Multiple Myeloma Cells to MSCs Contributes to Osteogenesis

The authors identified that bioactive lncRNA RUNX2-AS1 in myeloma cells could be packed into exosomes and transmitted to MSCs, thus repressing the osteogenesis of MSCs. [Oncogene] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass

Investigators used Pt_57.5Cu_14.7Ni_5.3P_22.5 bulk metallic glass with nanopatterned surfaces achieved by thermoplastic forming to influence differentiation of human MSCs. [Sci Rep] Full Article

An Immortalized Mesenchymal Stem Cell Line Maintains Mechano-Responsive Behavior and Can Be Used as a Reporter of Substrate Stiffness

Researchers showed that an immortalized, clonal line of human MSCs maintains the responsiveness to substrate mechanics observed in primary cells, and can be used as a reporter of stiffness. [Sci Rep] Full Article

Phospholipase C Delta 4 (PLCδ4) Is a Nuclear Protein Involved in Cell Proliferation and Senescence in Mesenchymal Stromal Stem Cells

Human PLCδ4 was found to be mainly nuclear in human adipose-derived mesenchymal stem cells (hASC). PLCδ4 knockdown demonstrated that it is essential for hASC proliferation, without inducing cell death. [Cell Signal] Abstract

Time-Dependent Contribution of BMP, FGF, IGF, and HH Signaling to the Proliferation of Mesenchymal Stroma Cells during Chondrogenesis

Human MSC were subjected to chondrogenesis in the presence or absence of pathway inhibitors or activators up to day 14 or from days 14 to 28, before proliferation, DNA and proteoglycan content were quantified. [J Cell Physiol] Abstract

The Therapeutic Effect of Mesenchymal Stem Cells on Pulmonary Myeloid Cells following Neonatal Hyperoxic Lung Injury in Mice

Researchers investigated the modulation of myeloid cell sub-populations and the reduction of fibrosis in the lungs following administration of human MSCs to neonatal mice exposed to hyperoxia. [Respir Res] Full Article

CGRP Gene-Modified rBMSCs Show Better Osteogenic Differentiation Capacity In Vitro

Overexpression of the calcitonin gene-related peptide (CGRP) gene significantly promoted rat bone MSC (rBMSC) proliferation. In addition, expressions of osteogenesis-related indexes were upregulated in the CGRP group compared with vector and control groups, and more mineralization nodules were observed in the CGRP group. [J Mol Histol] Abstract

IN VIVO

Mesenchymal Stromal Cells-Derived Matrix Gla Protein Contribute to the Alleviation of Experimental Colitis

Scientists investigated whether the abundant MSCs-derived matrix Gla protein (MGP) participate in the therapeutic mechanisms for MSCs treating Crohn’s disease. Obvious suppression of cell proliferation and cytokine production in T cells were observed in vitro through MSCs-derived MGP. [Cell Death Dis] Full Article

Intraperitoneal Infusion of Mesenchymal Stem Cell Attenuates Severity of Collagen Antibody Induced Arthritis

Researchers showed that MSCs alleviated the clinical and histological signs of synovitis in collagen antibody-induced arthritis mice. Peritoneal lavage cells from mice treated with MSCs expressed higher levels of stromal cell-derived factor-1α and regulated on activation, normal T cell expressed and secreted than those from mice not treated with MSCs. [PLoS One] Full Article

Immunoregulatory Mechanisms of Mesenchymal Stem and Stromal Cells in Inflammatory Diseases

The authors review current understanding of the immunomodulatory mechanisms of MSCs and the issues related to their therapeutic applications. [Nat Rev Nephrol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Cynata Reports Positive Six-Month Data from Cohort A in Phase I Trial of CYP-001 in GvHD

Cynata Therapeutics Limited announced positive safety and sustained overall survival rates from a six month follow-up assessment of patients enrolled in Cohort A of its Phase I clinical trial of CYP-001, the company’s lead Cymerus™ mesenchymal stem cell product candidate, in steroid-resistant acute graft-versus-host disease (GvHD).” [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

VistaGen Therapeutics Receives Notice of Allowance for Japanese Patent for Use of Stem Cells to Treat Cancer and Autoimmune Disorders

VistaGen Therapeutics, Inc. and its wholly-owned stem cell technology-focused subsidiary, VistaStem Therapeutics, Inc., announced that the Japanese Patent Office has issued a Notice of Allowance for a patent related to certain methods for producing blood cells, platelets and bone marrow stem cells. [VistaGen Therapeutics, Inc.] Press Release

Leading Salk Scientist Resigns after Allegations of Harassment

The prominent cancer biologist Inder Verma unconditionally resigned from the Salk Institute for Biological Studies in San Diego, California, June 6, and the research institute’s board of trustees voted unanimously to accept his resignation. [ScienceInsider] Editorial

China Introduces Sweeping Reforms to Crack Down on Academic Misconduct

China is getting tough on scientific misconduct. The country’s most powerful bodies, the Chinese Communist Party and the State Council, introduced a raft of reforms on 30 May aimed at improving integrity across the research spectrum, from funding and job applications to peer-review and publications. [Nature News] Editorial

More Restrictive U.S. Policy on Chinese Graduate Student Visas Raises Alarm

Reversing yet another policy of the previous administration, the U.S. Department of State began applying tougher restrictions on some Chinese graduate students. The new policy shortens from five years to one year the duration of visas for those planning to study aviation, robotics, and advanced manufacturing. [ScienceInsider] Editorial

NEW The New York Stem Cell Foundation (NYSCF) Conference
October 23-24, 2018
New York, New York, United States

Visit our events page to see a complete list of events in the community.

NEW Canada Excellence Research Chair – Cardiac Regeneration (University of Toronto and The Hospital for Sick Children)

Research Associate – Advanced Cell Culture Biology (The University of Manchester)

Experimental Postdoctoral Position – Single-Cell Functional Genomics (Heidelberg University)

Postdoctoral Researcher – Stem Cell Based Regenerative Medicine (Karolinska Institutet)

Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia)

Postdoctoral Research Assistant – Cell Biology (University of Oxford)

Postdoctoral Researcher – Skeletal Cell Metabolism in Bone Pathology and Regeneration (KU Leuven)

Postdoctoral Position – Cell Biology (University of Houston)

Review Scientists – Gene and Cell Therapy (Center for Biologics Evaluation and Research)

Postdoctoral Fellow/Senior Scientist – Aortic Aneurysm and Postnatal Bone Growth (Icahn School of Medicine at Mount Sinai)

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