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Pulmonary Cell News| Mesenchymal Cell News 10.33 August 21, 2018 | |
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TOP STORYHoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Researchers showed that a single Hoxc gene was sufficient to activate dormant mesenchymal dermal papilla niches and promoted regional hair follicle regeneration through canonical Wnt signaling. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROInvestigators found that MSCs derived from diabetic patients with critical limb ischemia not only exhibited a prothrombotic profile but also had altered multi-differentiation potential, reduced proliferation, and inhibited migration and homing to sites of inflammation. They demonstrated that this aberrant cell phenotype was reversed by the platelet-derived growth factor (PDGF) BB, indicating that PDGF signaling is a key regulator of MSC functionality. [Mol Ther] Abstract | Graphical Abstract Umbilical cord tissue-MSCs expanded using platelet lysate (PL) displayed typical immunophenotype, plasticity, immunomodulatory property and chromosomal stability. PL supplementation showed two-fold increase in MSC yield from explant culture with improved immunomodulatory activity as compared to enzymatically dissociated cultures. [Sci Rep] Full Article Evaluation of Placental Mesenchymal Stem Cell Sheets for Myocardial Repair and Regeneration Scientists found that placental MSC (pMSC) cardiac protein content was enhanced by differentiation media treatment, but no beating cells were produced. However, undifferentiated pMSCs improved migration and proliferation of a cardiac cell population. Undifferentiated pMSCs formed intact, aligned cell sheets. [Tissue Eng Part A] Abstract Human MSCs-seeded scaffold in dynamic culture exhibited homogenous cell distribution, proliferation and higher cell density at the core than static culture. Quantitative-PCR analysis showed upregulation of cartilage-specific genes, thereby confirming the chondrogenic differentiation. [Regen Med] Abstract | Graphical Abstract IN VIVOEmbryonic stem cell-derived MSCs (EMSCs) in spheres intrathecally injected into the central nervous system (CNS), remarkably reduced the clinical symptoms, brain lesions, and neuronal demyelination in experimental autoimmune encephalomyelitis monkeys during a three-month observation. EMSCs transdifferentiated into neural cells in vivo in the CNS of the treated animals. [Cell Death Discov] Full Article The CURE-iv trial was a Phase I, uncontrolled, open label trial for rheumatoid arthritis patients with moderate disease activity despite treatment with methotrexate. Reduced levels of IL-1β, IL-6, IL-8, and TNF-α at 24 hours were observed in the cluster infused with 1 × 108 MSCs. [Stem Cells Transl Med] Full Article Recipients had improved locomotive activity on a rotarod test and their sciatic function index, which suggested that transplanted human tonsil-derived stem cells differentiated into Schwann cells ameliorated demyelination and atrophy of nerve and muscle in trembler-J mice. [Int J Mol Sci] Full Article Meningitis modeling induced robust proliferation of E. coli in cerebrospinal fluid and increased mortality in rat pups, and MSC transplantation significantly reduced this bacterial growth and the mortality rate. MSC transplantation attenuated meningitis caused brain injury including cerebral ventricular dilatation, brain cell death, reactive gliosis, and inflammatory response. [Pediatr Res] Abstract | Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSAdipose-Derived Stem Cells: Effectiveness and Advances in Delivery in Diabetic Wound Healing Through a comprehensive literature search of published and ongoing studies, the authors provide an overview of the experimental basis, the scientific background, and advances in the delivery of adipose-derived stem cells for treating non-healing diabetic wounds. [Biomed Pharmacother] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSDr. Hsu to Continue Stem Cell Research with $2.5 Million Grant Wei Hsu, Ph.D., dean’s professor of Biomedical Genetics in the Center for Oral Biology and a scientist with the Eastman Institute for Oral Health at the University of Rochester Medical Center, received a $2.5 million, five year grant to continue his groundbreaking work involving the role of stem cells in tissue regeneration and reconstructive surgical repair. [University of Rochester Medical Center] Press Release PolyU Develops Novel Self-Fitting Scaffold for Bone Regeneration Researchers from The Hong Kong Polytechnic University (PolyU) have designed and fabricated a high performing self-fitting bone scaffold by combining a shape memory foam and hydroxyapatite. It can be safely and conveniently implanted into bone defects and induce bone regeneration, thus enhancing the recovery of bone injuries and fractures. [The Hong Kong Polytechnic University] Press Release IU School of Medicine Launches Regenerative Medicine Center Indiana University (IU) School of Medicine is investing more than $20 million over the next five years to establish a new center focused on regenerative medicine, a rapidly developing field aimed at repairing and replacing tissue and organs damaged by age, disease or trauma. [Indiana University School of Medicine] Press Release | |
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POLICY NEWSSalk Institute Asks Judge to Narrow Scope of Gender-Discrimination Suit Lawyers representing the Salk Institute for Biological Studies went to court on 17 August in San Diego, California, asking a judge to narrow the scope of a gender-discrimination lawsuit filed by molecular biologist Beverly Emerson. [Nature News] Editorial Prominent Health Policy Researcher Plagiarized Colleagues’ Work, Dartmouth Investigation Finds A Dartmouth College investigation has concluded that Dr. H. Gilbert Welch, one of the country’s most prominent health care policy scholars, committed research misconduct in connection with a paper published in a top medical journal. [STAT News] Editorial
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EVENTSNEW Stem Cells & Organoids in Development & Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Positions – Biomedical Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Research Fellow – Spinal Fusion (Hopkins Spinal Fusion Laboratory) Postdoctoral Fellow – Stem Cell Biology (Washington University School of Medicine in St. Louis) PhD Student Positions – Regenerative Medicine (University Medical Center Utrecht) Senior Lecturer – Stromal Immunology (University of Aberdeen) Faculty Position – Cellular Physiology and Engineering (Mayo Clinic) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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