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Pulmonary Cell News| Mesenchymal Cell News 10.35 September 4, 2018 | |
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TOP STORYGrowth of breast cancer patient-derived xenograft tumors was significantly enhanced by co-transplantation with adipose-derived stem cells (ADSCs) in vivo, and it was weakened when co-transplanted with adipsin knocked-down ADSCs. [Oncogene] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROEnhanced Articular Cartilage Regeneration with SIRT1-Activated MSCs Using Gelatin-Based Hydrogel During chondrogenic differentiation in vitro, resveratrol (RSV)-treated MSCs had higher differentiation potential and reduced hypertrophic maturation, which are limitations for hyaline cartilage formation. The expression levels of chondrogenic markers increased and those of hypertrophic markers decreased in RSV-treated MSCs compared with untreated MSCs. [Cell Death Dis] Full Article miR-431 expression was decreased during adipogenesis of human MSCs (hMSCs). The expression of insulin receptor substance 2 (IRS2) was increased during adipogenic differentiation of hMSCs in conjunction with decreased levels of miR-431, and knockdown of IRS2 in hMSCs inhibited adipogenic differentiation. [Stem Cell Res Ther] Full Article Using computed tomographic imaging and histological staining, scientists found that treatment of mandibular defects using 3-D cultured bone marrow-derived MSCs/demineralized bone matrix (DBM) autografts offered improvements in bone formation over both 2-D cultured autografts and cell-free DBM scaffolds. They found increased osteoid formation in 3-D and 2-D cultures, with more osteogenic cells present in the 3-D constructs. [J Mater Sci Mater Med] Abstract IN VIVOResearchers found that menstrual blood-derived MSC (MenSC) transplantation improved hind limb motor function. They showed that MenSCs treatment markedly reduced cavity formation in the lesion site. The improved motor function of hind limb and the increased cell body area of motor neurons were suppressed by blocking of the brain-derived neurotrophic factor-TrkB signaling. [Cell Death Dis] Full Article Compared to a bare metal stent or a parental umbilical cord blood-derived MSC (UCB-MSC)-coated stent, the stents with stem cells capable of the controlled release of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) successfully reduced restenosis within the stent and induced natural re-endothelialization. [Exp Mol Med] Full Article Flow cytometry analyses revealed that intravenous substance P promoted the mobilization of endogenous CD45−CD11b−CD29+ MSCs after bone defect. Micro-CT showed that intravenous substance P improved the outcomes of calvarial bone repair. Investigators discovered that systemic injection of substance P attenuated inflammation and enhanced the survival of the local-transplanted GFP+ MSCs. [Sci Rep] Full Article In vivo, cerebellar degeneration-related protein 1 transcript (CDR1as) knockdown led to less bone formation compared with the control group. Downregulation of CDR1as or growth differentiation factor 5 (GDF5) inhibited phosphorylation of Smad1/5/8 and p38 mitogen-activated protein kinases (MAPK), while upregulation of miR-7 decreased the level of phosphorylated Smad1/5/8 and p38 MAPK. [Stem Cell Res Ther] Full Article Translin Modulates Mesenchymal Cell Proliferation and Differentiation in Mice Translin-deficient bone marrow-derived mesenchymal stem cells showed substantial expansion in vivo and enhanced proliferation in vitro. These cells also showed enhanced osteogenic and adipocytic differentiation. [Biochem Biophys Res Commun] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSThe authors focus on the currently revealed reactive oxygen species generation mechanisms and the regulatory routes for controlling their rates of proliferation, survival, senescence, apoptosis, and differentiation. [J Cell Mol Med] Full Article Researchers review the current knowledge concerning different types of anti-chondrogenic regulators. They highlight novel therapeutic targets for cartilage repair and discuss suitable tools for suppressing their anti-chondrogenic functions. [J Orthop Res] Abstract MSC Functionalization for Enhanced Therapeutic Applications Investigators discuss how phenotype-based MSC purification and MSC priming technologies can contribute to an improved MSC-based product for safer and more effective therapeutic applications. [Tissue Eng Part B Rev] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSKey Biologics and Blood Centers of America Partner to Advance Cell Therapy and Regenerative Medicine Key Biologics LLC and Blood Centers of America announced an agreement to formalize their existing business relationship and to work collectively to broaden support for cell therapy and regenerative medicine. [Blood Centers of America] Press Release Cynata CYP-001 Stem Cell Therapy Meets All Safety and Efficacy Endpoints in Phase I Trial in GvHD Cynata Therapeutics Limited announced that CYP-001, its lead Cymerus™ MSC product candidate, met all clinical endpoints in a Phase I trial for the treatment of steroid-resistant acute graft-versus-host disease (GvHD). [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release The SanBio Group announced the acquisition of a patent portfolio regarding cell medicines derived from mesenchymal stem cells. [SanBio Co,Ltd. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSRadical Open-Access Plan Could Spell End to Journal Subscriptions Research funders from France, the United Kingdom, the Netherlands and eight other European nations have unveiled a radical open-access initiative that could change the face of science publishing in two years — and which has instantly provoked protest from publishers. [Nature News] Editorial World Bank Pours Hundreds of Millions into African Science A World Bank scheme aimed at building grassroots research capacity in Africa will nearly double its budget with a third, and probably final, investment worth at least US$280 million. [Nature News] Editorial
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EVENTSNEW 7th Annual International Symposium on Regenerative Rehabilitation Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Post-Doctoral Researcher – Mesenchymal Stem Cell Therapy in Severe Asthma (Maynooth University) Postdoctoral Researcher – Interdisciplinary (Oregon Health & Science University) Faculty Positions – Biomedical Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Research Fellow – Spinal Fusion (Hopkins Spinal Fusion Laboratory) Postdoctoral Fellow – Stem Cell Biology (Washington University School of Medicine in St. Louis) Senior Lecturer – Stromal Immunology (University of Aberdeen) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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