Mesenchymal Cell News Volume 11.04 | Feb 5 2019

TOP STORY

HBV Infection-Induced Liver Cirrhosis Development in Dual-Humanized Mice with Human Bone Mesenchymal Stem Cell Transplantation

The Generated human bone marrow mesenchymal stem cells-Fah^-/-Rag2^-/-IL-2Rγc^-/- SCID mice were subjected to assessments of sustained viremia, specific immune and inflammatory responses and liver pathophysiological injury to characterize the progression of chronic hepatitis and cirrhosis after hepatitis B virus infection. [Gut] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Volume Expansion and TRPV4 Activation Regulate Stem Cell Fate in Three-Dimensional Microenvironments

Investigators found that mesenchymal stem cells in viscoelastic hydrogels exhibited volume expansion during cell spreading, and greater volume expansion was associated with enhanced osteogenesis. [Nat Commun] Full Article

Soluble Matrix Protein Is a Potent Modulator of Mesenchymal Stem Cell Performance

The authors showed that tropoelastin alone drives mesenchymal stem cell proliferation and phenotypic maintenance, akin to the synergistic effects of potent growth factors such as insulin-like growth factor 1 and basic fibroblast growth factor. [Proc Natl Acad Sci USA] Full Article

Mass Spectrometry-Based Absolute Quantification of 20S Proteasome Status for Controlled Ex-Vivo Expansion of Human Adipose-Derived Mesenchymal Stromal/Stem Cells

Researchers presented a method to determine the absolute quantity and stoichiometry of ubiquitous and tissue-specific human 20S proteasome subtypes based on a robust, absolute SILAC-based multiplexed LC-selected reaction monitoring quantitative mass spectrometry assay with high precision, accuracy, and sensitivity. It was then successfully applied to reveal IFNγ- and O₂-dependent variations of proteasome status during primary culture of adipose-derived-mesenchymal stromal/stem cells. [Mol Cell Proteomics] Abstract

High Doses of Synthetic Antioxidants Induce Premature Senescence in Cultivated Mesenchymal Stem Cells

Scientists examined the effects of different antioxidants on mesenchymal stem cells maintained in normal physiological conditions. They used high, but non-cytotoxic antioxidant doses which are widely used in laboratory practice to protect cells from oxidative damage. [Sci Rep] Full Article

Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone Metabolism

Gene expression analysis was performed in multiple myeloma-mesenchymal stem cells (MSC) and normal donors-MSC after in vitro expansion. To validate these findings, some genes were selected to be evaluated by quantitative real time PCR, and also functional in vitro analyses were performed. [Sci Rep] Full Article

Effect of Magnesium on Reducing the UV-Induced Oxidative Damage in Marrow Mesenchymal Stem Cells

In this study, in order to explore the property of anti-oxidative damage of magnesium (Mg) metal, rat bone marrow mesenchymal stem cells (MSCs) oxidative damaged by UV radiation was employed to co-culture with Mg metal. The effect of Mg metal on the response of antioxidant enzymes and mitochondria in MSCs was studied. [J Biomed Mater Res A] Abstract

IN VIVO

Exosomes from Hypoxia-Treated Human Adipose-Derived Mesenchymal Stem Cells Enhance Angiogenesis through VEGF/VEGF-R

Exosomes were collected from normoxia-treated or hypoxia-treated human adipose mesenchymal stem cells, and their pro-angiogenic capacity was evaluated in human umbilical vein endothelial cells and a nude mouse model of subcutaneous fat grafting. [Int J Biochem Cell Biol] Abstract

TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model

Scientists established tauroursodeoxycholic acid (TUDCA)-treated mesenchymal stem cells (MSCs) using MSCs isolated from patients with chronic kidney disease (CKD-hMSCs) and assessed the survival and ROS generation of neural cell line SH-SY5Y cells by co-culturing with TUDCA-treated CKD-hMSCs. [Int J Mol Sci] Full Article

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Mesenchymal Stem Cells in Suppression or Progression of Hematologic Malignancy: Current Status and Challenges

The authors emphasize that research on the therapeutic applications of mesenchymal stem cells must consider that they exert both antitumorigenic and protumorigenic effects on hematologic malignancies. [Leukemia] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Samumed to Present Novel Biological Targets of SM04690 for Treatment of Knee Osteoarthritis

Samumed, LLC, announced that it will present data introducing the novel mechanism of action of SM04690, its investigational small-molecule Wnt pathway inhibitor currently in development as a potential disease-modifying treatment for knee osteoarthritis. [Press release from Samumed, LLC discussing research presented at Orthopaedic Research Society 2019 Annual Meeting, Austin] Press Release

Hitachi Chemical Co. Ltd. to Acquire apceth Biopharma GmbH, Expanding Global Footprint of Its Cell and Gene Therapy Contract Development and Manufacturing Services

Hitachi Chemical Advanced Therapeutics Solutions, LLC announced an agreement by which apceth Biopharma GmbH will join Hitachi Chemical’s PCT global services platform. [Hitachi Chemical Advanced Therapeutics Solutions, LLC (Business Wire, Inc.)] Press Release

Thousands of Scientists Run Up against Elsevier’s Paywall

Researchers at German institutions that have let their Elsevier subscriptions lapse while negotiating a new deal are hitting the paywall for the publisher’s most recent articles around 10,000 times a day, according to Elsevier — which publishes more than 400,000 papers each year. [Nature News] Editorial

Indian Government to Boost Stipend for Early-Career Scientists

The Indian government announced that it will increase the stipend for PhD students who have qualified for a research fellowship by up to 25%. [Nature News] Editorial

NEW Regenerative Medicine Workshop
March 20-23, 2019
Isle of Palms, South Carolina, United States

Visit our events page to see a complete list of events in the community.

NEW Research Scientist – Stem Cell Biology (MD Anderson Cancer Center)

Stem Cell Production Officer – Clinical Grade MSCs (University of London – Royal Veterinary College)

Postdoctoral Fellow – MSC Research (University of Illinois at Chicago College of Medicine)

PhD Positions – Cancer Biology (Institut Curie)

Postdoctoral Training Fellow – Cancer Genomics (The Francis Crick Institute)

Assistant Professor – Sarcoma & Skeletal-Related Malignancies (UC Davis School of Medicine)

Postdoctoral Fellow – Stem Cell Biology (City of Hope)

Research Fellow – Stem Cell Biology (Brigham & Women’s Hospital – Harvard Medical School)

Post Doctoral Fellow – Stem Cell Biology (Technion – Israel Institute of Technology)

Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine)

Assistant Professor – Department of Biological Sciences (Rutgers University Newark)

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