Mesenchymal Cell News Volume 11.21 | May 31 2022

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    2022-05-31 | MESCN 11.21


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 11.21 – 31 May, 2022
    TOP STORY

    Stem Cell Membrane-Encapsulated Zeolitic Imidazolate Framework-8: A Targeted Nano-Platform for Osteogenic Differentiation

    Nanoscale zeolitic imidazolate framework-8, a Zn-based metal–organic framework, was modified to direct MSCs toward an osteoblast lineage.
    [Small]

    Abstract
    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    Interaction Between Mesenchymal Stem Cells and Myoblasts in the Context of Facioscapulohumeral Muscular Dystrophy Contributes to the Disease Phenotype

    Scientists used cell motility assays and co-culture of mesenchymal stem cells with myoblasts to study their mutual effects on cell migration, differentiation, proliferation, and extracellular matrix formation.
    [Journal of Cellular Physiology]

    Full Article

    Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes for Treating Traumatic Pancreatitis in Rats

    The authors established a rat model of traumatic pancreatitis and evaluated and compared the therapeutic effects of human umbilical cord (hUC)-MSCs and hucMSC-exosomes.
    [Stem Cell Research & Therapy]

    Full Article

    Magnetic Exposure Using Samarium Cobalt (SmCO5) Increased Proliferation and Stemness of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs)

    Researchers investigated the impact of induced static MF on hUC-MSCs using SmCO5.
    [Scientific Reports]

    Full Article

    Morinda officinalis Polysaccharide Regulates Rat Bone Mesenchymal Stem Cell Osteogenic–Adipogenic Differentiation in Osteoporosis by Upregulating miR-21 and Activating the PI3K/AKT Pathway

    ZIF-8 nanoparticles were encapsulated using stem cell membranes to mimic natural molecules and improve the biocompatibility and targeted ability toward MSCs.
    [Kaohsiung Journal of Medical Sciences]

    Abstract

    MMP2 Promotes Osteoblast Differentiation and Calcification of Muscle-Derived Mesenchymal Stem Cells by Interaction with miR-29b-3p

    Researchers found that matrix metalloproteinase 2 (MMP2) could facilitate the osteoblast differentiation and calcification of muscle-derived MSCs by up-regulating the expression of some typical osteogenic differentiation phenotype markers, such as runt-related transcription factor 2, alkaline phosphatase, and osteocalcin.
    [Tissue and Cell]

    Abstract

    Investigation of the Effect of IFN-γ/TNF-α-Treated Mesenchymal Stem Cells on Th9- and Treg Cell-Related Parameters in a Mouse Model of Ovalbumin-Induced Allergic Asthma

    The modulatory effects of IFN-γ/TNF-α-induced MSCs on Th9- and Treg cell-related parameters were investigated using an asthma model.
    [Immunopharmacology and Immunotoxicology]

    Abstract

    Oral Delivery of Stem-Cell-Loaded Hydrogel Microcapsules Restores Gut Inflammation and Microbiota

    The oral delivery of stem-cell-loaded hydrogel microcapsules enhanced MSC survival and retention in the hostile stomach environment due to the intermediate oil layer and low value of the overall stiffness.
    [Journal of Controlled Release]

    AbstractGraphical Abstract

    Therapeutic Effects of Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells on a Murine Model of Acute Type-2-Dominated Airway Inflammation

    The authors investigated the effects of human iPSC-derived MSCs on airway hyperresponsiveness and acute type-2-dominated inflammation throughout the upper and lower airways.
    [Stem Cell Reviews and Reports]

    Abstract

    Standard Toxicity Study of Clinical-Grade Allogeneic Human Bone Marrow-Derived Clonal Mesenchymal Stromal Cells

    Investigators determined the probable toxicity effects of local and systemic injections of cryopreserved human bone marrow-derived clonal MSCs during subacute and subchronic periods of time.
    [Stem Cell Research & Therapy]

    Full Article
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Carcinoma Associated Mesenchymal Stem/Stromal Cells – Architects of the Pro-Tumorigenic Tumor Microenvironment

    Scientists review the impact of carcinoma-associated (CA)-MSCs on cancer progression and metastasis and the ongoing work on CA-MSC identification, nomenclature and mechanism of action.
    [Stem Cells]

    AbstractGraphical Abstract

    Roles of Circular RNAs in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

    Further studies on the role of circRNAs in the osteogenic differentiation of BMSCs can provide a new theoretical and experimental basis for bone tissue engineering and clinical treatment.
    [Molecular Medicine Reports]

    Abstract
    INDUSTRY AND POLICY NEWS

    UCalgary Student’s Stem Cell Research Paper Wins National Award

    The University of Calgary (UCalgary) PhD student, who has always wanted to work in the health field, found her calling after completing her undergraduate degree in chemical engineering, with a specialization in biomedical engineering.
    [University of Calgary]

    Press Release
    FEATURED EVENT

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    June 26 – 28, 2022
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    JOB OPPORTUNITIES

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    China Medical University – Shenyang, China

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    Utrecht University – Utrecht, Netherlands

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    Baylor College of Medicine – Houston, Texas, United States

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