Mesenchymal Cell News Volume 11.39 | Oct 8 2019

TOP STORY

5 PicoNewtons – The Difference Between Osteogenic and Adipogenic Fate Choice in Human Mesenchymal Stem Cells

Investigators utilised self-assembled, block copolymer surfaces to present nanodomains of an adhesive peptide found in many extracellular matrix proteins at different lateral spacings and studied the temporal response of human MSCs using a panel of real-time localization and activity biosensors. [ACS Nano] Abstract

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IN VITRO

Transcriptomic Profiling of the Myeloma Bone-Lining Niche Reveals BMP Signaling Inhibition to Improve Bone Disease

Using transcriptomic profiling of isolated bone lining cell subtypes from a murine myeloma model, scientists found that bone morphogenetic protein (BMP) signaling was upregulated in stromal progenitor cells. [Nat Commun] Full Article

Extracellular IL-37 Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Activation of the PI3K/AKT Signaling Pathway

Extracellular interleukin (IL)-37 significantly increased osteoblast-specific gene expression, the number of mineral deposits, and alkaline phosphatase activity of MSCs. [Cell Death Dis] Full Article

Nuclear Shape, Protrusive Behavior and In Vivo Retention of Human Bone Marrow Mesenchymal Stromal Cells Is Controlled by Lamin-A/C Expression

Scientists demonstrated that human MSCs displayed remarkable low migratory behaviour compared to other mesodermal-derived primary human cell types. [Sci Rep] Full Article

Polyamine Supplementation Reduces DNA Damage in Adipose Stem Cells Cultured in 3D

To establish whether polyamines could protect adipose derived stem cells against oxidative DNA damage in a 3D differentiation model, the level of γH2AX was measured by western blot, and found to correlate with age and BMI of patients. [Sci Rep] Full Article

Maintenance of Neurogenic Differentiation Potential in Passaged Bone Marrow-Derived Human Mesenchymal Stem Cells under Simulated Microgravity Conditions

Immunostaining, quantitative RT-PCR, and western blot analysis of neurogenic differentiation markers, neurofilament heavy, and microtubule-associated protein 2 revealed that differentiated cells from the cells cultured under simulated microgravity conditions expressed higher neurogenic levels than those from conventional gravity conditions. [Stem Cells Dev] Abstract

Effects of Combination TGF-B1 Transfection and Platelet Rich Plasma (PRP) on Three-Dimension Chondrogenic Differentiation of Rabbit Dental Pulp-Derived Mesenchymal Stem Cells

Researchers showed that the combination in culture medium of transforming growth factor-beta 1 (TGF-B1) gene transfection and 10% PRP were accelerated in chondrogenic differentiation of dental pulp-derived MSCs. [Connect Tissue Res] Abstract

Morphogen Delivery by Osteoconductive Nanoparticles Instructs Stromal Cell Spheroid Phenotype

MSC spheroids containing BMP-2-loaded hydroxyapatite (HA) nanoparticles exhibited greater alkaline phosphatase activity and more uniform spatial expression of osteocalcin compared to spheroids with uncoated HA nanoparticles. [Adv Biosyst] Abstract

IN VIVO

The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice

The authors showed that the growth and immune rejection of engineered human fibroblastic tumors was not altered by the injection of human umbilical cord-derived MSCs in immune-deficient or humanized mice, respectively. [J Immunol] Abstract

Mesenchymal Stem Cells and Treadmill Trainnig Enhance Function and Promote Tissue Preservation after Spinal Cord Injury

Researchers investigated whether cell therapy associated with physical activity after mouse spinal cord injury could promote morphological and functional outcomes. [Brain Res] Abstract

Bone Marrow-Mesenchymal Stem Cells Modulate Microglial Activation in the Peri-Infarct Area in Rats during the Acute Phase of Stroke

The transplanted bone marrow MSCs exerted immunomodulatory effect by inactivating the microglias in the peri-infarct area, at least partially, via the CD200-CD200R1 signaling. [Brain Res Bull] Abstract

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Autophagy in Bone Homeostasis and the Onset of Osteoporosis

The authors introduce the topic of autophagy, summarize the understanding of its relevance in bone physiology, and discuss its role in the onset of osteoporosis and therapeutic potential. [Bone Res] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Cynata Advances Toward Phase II Clinical Trial of Cymerus^™ MSCs in Patients with Osteoarthritis

Cynata Therapeutics Limited provided an update on start-up activities of a Phase II clinical trial to evaluate Cynata’s Cymerus^™ MSCs as a treatment for osteoarthritis, following the signing of an agreement with the University of Sydney. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

BrainStorm Announces Notice of US Patent Allowance for NurOwn^® Cellular Therapeutic Technology Platform

BrainStorm Cell Therapeutics Inc. announced that the United States Patent and Trademark Office has issued a Notice of Allowance for BrainStorm’s new US Patent Application, number: 15/113,105, titled: ‘Method of Qualifying Cells’. [BrainStorm Cell Therapeutics Inc.] Press Release

‘More Women Are Being Nominated’: Nobel Academy Head Discusses Diversity

Ahead of this year’s award announcements, Göran Hansson speaks about measures to address the imbalance in gender and ethnicity among winners. [Nature News] Editorial

Biologists Who Decoded How Cells Sense Oxygen Win Medicine Nobel

A trio of researchers has won the 2019 Nobel Prize in Physiology or Medicine for describing how cells sense and respond to changing oxygen levels by switching genes on and off — a discovery that has been key in understanding human diseases such as cancer and anemia. [Nature News] Editorial

There’s No Taboo, No Bad Ideas’: Anyone Can Help Shape European Union’s New €94 Billion Research Program

These encouraging words were spoken here last week at the European Research and Innovation Days, where policy bigwigs working with the European Commission invited the audience to help shape Europe’s next seven-year research funding program, Horizon Europe, set to begin in 2021. Their message: Anyone can help “cocreate” the program’s outlines. [ScienceInsider] Editorial

NEW ISSCR 2020 Stem Cells and Regenerative Medicine
March 13-15, 2020
Shanghai, China

Visit our events page to see a complete list of events in the community.

NEW Assistant Professor – Cell and Molecular Biology (Boston University)

NEW Tier 2 Canada Research Chairs – Stem Cell Biology (Simon Fraser University (SFU))

Postdoctoral Researcher – Stem Cells (University of South Florida)

Postdoctoral Fellow – Stem Cells (The Francis Crick Institute)

Postdoctoral Fellow – Stem Cell Plasticity (Univeristy of Technology)

Lecturer – Stem Cell Biology (The University of Manchester)

Assistant Professors – Regenerative Medicine (Washington University in St. Louis)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Postdoctoral Researcher – Development and Stem Cell Biology (California Institute of Technology)

Postdoctoral Researchers – Stem Cell Biology (Simon Fraser University)

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