Mesenchymal Cell News Volume 12.02 | Jan 21 2020

TOP STORY

A Wnt-Mediated Transformation of the Bone Marrow Stromal Cell Identity Orchestrates Skeletal Regeneration

Cell-lineage analysis using C-X-C motif chemokine ligand 12 (Cxcl12)-creER mice revealed that quiescent Cxcl12-creER⁺ perisinusoidal bone marrow MSCs differentiated into cortical bone osteoblasts solely during regeneration. [Nat Commun] Full Article

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IN VITRO

Sirt1-Overexpressing Mesenchymal Stem Cells Drive the Anti-Tumor Effect through Their Pro-Inflammatory Capacity

Researchers demonstrated that silent information regulator 1 (Sirt1)-overexpressing MSCs significantly exerted anti-tumor activity through increasing the number of CD8⁺ T cells. Sirt1 did not affect chemokines secretion in MSCs induced by inflammatory cytokines, but impaired the immunosuppressive ability of MSCs through suppressing inflammatory cytokines-stimulated iNOS production via deacetylating p65. [Mol Ther] Abstract | Graphical Abstract

Cardiac Nestin⁺ Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage Polarization

The authors demonstrated that Nestin was a suitable marker for cardiac MSCs, which were identified by their self-renewal ability, tri-lineage differentiation potential, and expression of MSC markers. [Mol Ther] Abstract | Graphical Abstract

P53 and Parkin Co-Regulate Mitophagy in Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Early Steroid-Induced Osteonecrosis of the Femoral Head

Scientists upregulated Parkin and downregulated P53 in bone marrow MSCs (BMSCs). They found that this significantly enhanced mitophagy in BMSCs, decreased the accumulation of damaged mitochondria in cells, effectively resisted stress-induced BMSCs apoptosis and senescence, and improved the effect of BMSCs transplantation on early steroid-induced osteonecrosis of the femoral head. [Cell Death Dis] Full Article

Novel Mouse MicroRNA Chr13_novelMiR7354-5p Improves Bone Marrow-Derived Mesenchymal Stem Cell Differentiation into Insulin-Producing Cells

Investigators used next-generation sequencing to detect the miRNA expression profile of normal mouse pancreatic β-cells, non-β-cells, bone marrow mesenchymal stem cells-MSCs and adipose-derived stem cells and determined relative miRNA expression levels in mouse pancreatic β-cells. [Mol Ther Nucleic Acids] Abstract

Mesenchymal Stem Cells Used as Carrier Cells of Oncolytic Adenovirus Results in Enhanced Oncolytic Virotherapy

To address the critical question of how MSCs loaded with oncolytic viruses affect virotherapy outcomes and tumor growth patterns in a tumor microenvironment, researchers developed and analyzed an integrated mathematical-experimental model. [Sci Rep] Full Article

Phenotypic, Transcriptional and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties

Given the known immunomodulatory properties of MSCs, investigators hypothesized that liver (L‐)MSCs were superior immunomodulators and contribute to liver‐mediated tolerance. L‐MSC, generated from human liver allograft biopsies were compared to MSCs from adipose tissue and bone marrow. [Liver Transpl] Abstract

Scaffold‐ and Serum‐Free Hypertrophic Cartilage Tissue Engineering as an Alternative Approach for Bone Repair

Human ASC spheroids were used as a serum‐free in vitro model to recapitulate the molecular events and extracellular matrix organization that orchestrated a hypertrophic cartilage phenotype. [Artif Organs] Abstract

IN VIVO

Tailorable Hydrogel Improves Retention and Cardioprotection of Intramyocardial Transplanted Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

When compared with adipose‐derived mesenchymal stem cells (ADSCs) alone, transglutaminase cross‐linked gelatin‐encapsulated ADSCs significantly enhanced the long‐term retention and cardioprotective effect of ADSCs against myocardial infarction‐induced cardiac injury. [J Am Heart Assoc] Abstract

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Human Adipose Tissue Derivatives as a Potent Native Biomaterial for Tissue Regenerative Therapies

The authors give the overview of next generation biomaterials derived from human adipose tissue and their development with clinical relevance. [J Tissue Eng Regen Med] Abstract

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ISSCR Announces 2020 Award Winners

Stem cell scientists and leaders earn 2020 International Society for Stem Cell Research (ISSCR) Awards for their significant contributions to the field of stem cell research. Honorees include Fred H. Gage, PhD, Salk Institute for Biological Studies and Mitinori Saitou, MD, PhD, Kyoto University. [The International Society for Stem Cell Research] Press Release

Campus Attacks by Nationalists and Police Alarm India’s Scientific Community

The attack on one of India’s most prestigious universities sent shock waves around the country and is the latest sign that the political forces tearing apart Indian society are also affecting the country’s academic community. Students at JNU, a liberal bastion, had been on strike for months against both a major hike in student fees and the government’s controversial Citizenship Amendment Act, widely decried as discriminatory against Muslims. [ScienceInsider] Editorial

Moffitt Cancer Center Details Links of Fired Scientists to Chinese Talent Programs

Six Florida cancer researchers who were dismissed last month for hiding their ties to a Chinese medical university appear to have been motivated by simple greed and a disregard for both institutional and federal rules. [ScienceInsider] Editorial

NEW EHA-SWG Mesenchymal Stromal Cells and Tissue Homeostasis
April 23-24, 2020
Rome, Italy

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NEW Postdoctoral Fellow – Cardiovascular Research (Temple University)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles)

Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York)

PhD Positions – Cell Biology (University of Warwick)

Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen)

PhD Student – Mammalian Development and Disease (Max Planck Institute for Molecular Genetics)

Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Faculty Positions – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

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