Mesenchymal Cell News Volume 12.12 | Mar 31 2020

TOP STORY

In Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia-Reperfusion Injury

Researchers revealed that the accumulated MSC-extracellular vesicles stimulated mitochondrial antioxidant defense and ATP production via activating the Keap1-Nrf2 signaling pathway, which protected tubular epithelia cells against oxidative insult by reducing mitochondrial fragmentation, normalizing mitochondrial membrane potential and increasing mitochondrial DNA copy number. [ACS Nano] Abstract

(Ranked by impact factor of the journal)

IN VITRO

LAMA2 Regulates the Fate Commitment of Mesenchymal Stem Cells via Hedgehog Signaling

Both in vitro and in vivo studies indicated that laminin α2 (LAMA2) inhibited osteogenesis and promoted adipogenesis. [Stem Cell Res Ther] Full Article

Loss of Receptor Tyrosine Kinase-Like Orphan Receptor 2 Impairs the Osteogenesis of mBMSCs by Inhibiting Signal Transducer and Activator of Transcription 3

Investigators revealed the role and mechanism of receptor tyrosine kinase-like orphan receptor 2 (Ror2) in the osteogenic differentiation from mouse bone marrow MSCs (mBMSCs) and explored the effect of signal transducer and activator of transcription 3 on Ror2-mediated osteogenesis. [Stem Cell Res Ther] Full Article

IN VIVO

In Vivo Priming of Human Mesenchymal Stem Cells with Hepatocyte Growth Factor-Engineered Mesenchymal Stem Cells Promotes Therapeutic Potential for Cardiac Repair

Primed bone marrow-derived MSCs through hepatocyte growth factor-expressing MSCs exhibited improved vasculogenic potential and cell viability, which ultimately enhanced vascular regeneration and restored cardiac function to the myocardial infarction hearts. [Sci Adv] Full Article

Cell Reprogramming Using Extracellular Vesicles from Differentiating Stem Cells into White/Beige Adipocytes

Stem cell extracellular vesicles (EVs) derived during differentiation were developed to use as cell-free therapeutic systems by inducing tissue-specific differentiation. EVs were isolated from human adipose-derived stem cells during white and beige adipogenic differentiation via tangential flow filtration. [Sci Adv] Full Article

Reversing Acute Kidney Injury Using Pulsed Focused Ultrasound and Mesenchymal Stromal Cell Therapy: A Role for Heat Shock Protein-Mediated PI3K/AKT Signaling

Researchers studied the effect of bone marrow-derived MSCs (BM-MSCs), in conjunction with focused ultrasound, in a mouse model of cisplatin-induced acute kidney injury. BM-MSCs improved kidney function, reduced histological markers of kidney injury, decreased inflammation and apoptosis, and promoted cellular proliferation. [Mol Ther Methods Clin Dev] Abstract | Full Article | Graphical Abstract

Activated Mesenchymal Stem Cells Induce Recovery following Stroke via Regulation of Inflammation and Oligodendrogenesis

Interferon-γ-activated mesenchymal stem cell (aMSCγ) treatment resulted in significant functional recovery assessed by the modified neurological severity score and open-field analysis compared with vehicle-treated animals. aMSCγ‐treated animals showed significant reductions in infarct size and inhibition of microglial activation. [J Am Heart Assoc] Abstract

Insulin-Producing Cells from Mesenchymal Stromal Cells: Protection against Cognitive Impairment in Diabetic Rats Depends upon Implant Site

Scientists investigated the strategy of implanting insulin-producing cells (IPCs) obtained from MSCs from adipose tissue, comparing two different IPC implant sites, subcapsular renal and subcutaneous, to show their putative protection against hippocampal damage, induced by STZ, in a rat type 1 diabetes mellitus model. [Life Sci] Abstract

miR-4651 Inhibits Cell Proliferation of Gingival Mesenchymal Stem Cells by Inhibiting HMGA2 under Nifedipine Treatment

Investigators found that overexpressed miR-4651 inhibited cell proliferation and induced G0/G1-phase arrest in gingival MSCs with or without nifedipine treatment. [Int J Oral Sci] Full Article

Exosomes Derived from GIT1-Overexpressing Bone Marrow Mesenchymal Stem Cells Promote Traumatic Spinal Cord Injury Recovery in a Rat Model

Researchers explored the effects of exosomes derived from G protein-coupled receptor kinase 2 interacting protein 1 (GIT1)-overexpressing bone marrow MSCs on the treatment of traumatic spinal cord injury in a rat model. [Int J Neurosci] Abstract

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Inflammation in Myocardial Injury- Stem Cells as Potential Immunomodulators for Myocardial Regeneration and Restoration

Current implications of using MSCs owing to their immunomodulatory functions and paracrine effects could serve as an effective alternative treatment option for rejuvenating the heart post myocardial infarction. [Life Sci] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Pluristem Treated First Three COVID-19 Patients in Israel under Compassionate Use

Pluristem Therapeutics Inc. announced that it has dosed three patients in two different hospitals in Israel under a compassionate use program for the treatment of COVID-19, as approved by the Israeli Ministry of Health. [Pluristem Therapeutics Inc.] Press Release

ImStem Biotechnology Announces FDA Has Lifted the Clinical Hold on the Investigational New Drug Application for IMS001 for the Treatment of Multiple Sclerosis

ImStem Biotechnology, Inc. announced that the FDA has lifted the clinical hold and cleared the Investigational New Drug application to evaluate IMS001 for the treatment of multiple sclerosis. [ImStem Biotechnology (PR Newswire Association LLC)] Press Release

Tens of Thousands of Scientists Are Redeploying to Fight Coronavirus

As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise. [Nature News] Editorial

Universities Issue Hiring Freezes in Response to COVID-19

Numerous universities have made announcements about the suspension of hiring, including Miami University of Ohio, Wright State University, Villanova University, the University of Nevada, Reno, Indiana University, and the University of Auckland in New Zealand, which cites the travel ban affecting Chinese students as one of the main causes of its freeze. [The Scientist] Editorial

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NEW Postdoctoral Fellow – Biomaterials and Nanotechnology in Regenerative Medicine (Guangzhou Medical University)

NEW Assistant Professor – Sarcoma (McGill University)

NEW Professor – Molecular Physiology (Karolinska Institutet)

Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Osteoarthritis, Mechanobiology, and Regenerative Medicine (Oklahoma Medical Research Foundation)

Postdoctoral Scholar – Cancer Research in Sarcoma (The Ohio State University)

Postdoctoral Position – Stem Cell Pluripotency, Reprogramming and Cancer Biology (Cancer Research Center of Lyon)

Senior Research Scientist or Postdoctoral Fellow – Sarcoma Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

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