Mesenchymal Cell News Volume 12.18 | May 12 2020

TOP STORY

Particle-Based Artificial Three-Dimensional Stem Cell Spheroids for Revascularization of Ischemic Diseases

Investigators introduced a particle-based artificial stem cell spheroid technology that recapitulated paracrine functions of 3D stem cell spheroids for vasculature regeneration. [Sci Adv] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids

Researchers examined whether the release of exogenous signaling molecules from hydrogels could promote the survival of MSC spheroids. [ACS Appl Mater Interfaces] Abstract

Irradiation Induces Cancer Lung Metastasis through Activation of the cGAS–STING-CCL5 Pathway in Mesenchymal Stromal Cells

cGAS-STING signaling pathway was found to be activated in MSCs, accompanied by upregulation of type I interferon-related genes, including chemokine CCL5. Disruption of cGAS-STING signaling in MSCs abolished their pro-metastatic effect. [Cell Death Dis] Full Article

Signature Quality Attributes of CD146⁺ Mesenchymal Stem/Stromal Cells Correlate to High Therapeutic and Secretory Potency

Mechanistically, CD146⁺ bone marrow-derived MSCs (BM-MSCs) were showed markedly higher secretory capacity with significantly greater immunomodulatory and anti-inflammatory protein production upon inflammatory priming compared to the CD146⁻ BM-MSC. [Stem Cells] Abstract

Mechanosensitive Regulation of Stanniocalcin-1 by Zyxin and Actin-Myosin in Human Mesenchymal Stromal Cells

Investigators showed that stanniocalcin-1 secretion was increased only under specific cell‐stress conditions. They found that this was due to a change in actin stress fibers and actin-myosin tension. [Stem Cells] Abstract

IN VIVO

p5 Peptide-Loaded Human Adipose-Derived Mesenchymal Stem Cells Promote Neurological Recovery after Focal Cerebral Ischemia in a Rat Model

In vivo administration of human adipose-derived MSCs loaded with a 24-residue peptide derived from p35 to post-stroke rats had no effect on the infarct volume. Nevertheless, the treatment led to improvement in functional recovery in spatial learning and memory, bilateral coordination and sensorimotor function, and asymmetry of forelimb usage. [Transl Stroke Res] Full Article

Exosomes Derived from hucMSC Attenuate Renal Fibrosis through CK1δ/β-TRCP-Mediated YAP Degradation

Infusion with human umbilical cord MSCs (hucMSCs) promoted yes-associated protein (YAP) nuclear cytoplasmic shuttling and ameliorated renal fibrosis in ureteral obstruction model. [Cell Death Dis] Full Article

Bone Marrow Mesenchymal Stem Cells Improve Bone Erosion in Collagen-Induced Arthritis by Inhibiting Osteoclasia-Related Factors and Differentiating into Chondrocytes

Bone marrrow MSC (BMSC) transplantation improved joint inflammation and inhibited bone destruction in collagen-induced arthritis rats. BMSCs inhibited the expression of serum CXCL10 and CXCL10 and CXCR3 expression at the synovial membrane. [Stem Cell Res Ther] Full Article

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

This prospective, non-randomized, open-label, cohort study addressed the safety and efficacy of exosomes derived from allogeneic bone marrow MSCs as treatment for severe COVID-19. [Stem Cells Dev] Full Article

Oncolytic Newcastle Disease Virus Delivered by Mesenchymal Stem Cells-Engineered System Enhances the Therapeutic Effects Altering Tumor Microenvironment

Tumor therapy experiments indicated that oncolytic Newcastle disease virus delivered by MSC-engineered system significantly reduced tumor growth, which was associated with the enhancement of E7-specific lymphocyte proliferation, CD8⁺ T cell cytolysis responses, and splenic IFN-γ, IL-4 and IL-12 responses compared with control groups. [Virol J] Full Article

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The Therapeutic Potential of Mesenchymal Stem Cells for Cardiovascular Diseases

Scientists review the potential and methods of MSC transplantation in the treatment of cardiovascular diseases and the challenges of the clinical use of MSCs. [Cell Death Dis] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Cynata Receives Ethics Approval to Commence Clinical Trial in COVID-19 and Clinical Development Update

Cynata Therapeutics Limited announced that it has received ethics committee approval to commence a clinical trial to investigate early efficacy of Cynata’s proprietary Cymerus^™ MSCs in adults admitted to intensive care with COVID-19. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

Coronavirus Shut-Downs Pose Huge Threat to Australian Research Jobs

Research in Australia will face drastic cuts in funding and jobs as a consequence of the COVID-19 pandemic and economic shut-downs, according to a report by organizations representing the country’s researchers and academia. [Nature News] Editorial

Secretive Jasons to Offer Advice on How to Reopen Academic Labs Shut by Pandemic

A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider] Editorial

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NEW Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine)

Research Fellow – Critical Limb Ischemia (National University of Ireland Galway)

Research Group Leaders – Structural Biology Research Centre (Fondazione Human Technopole)

Principal Investigators and Postdoctoral Fellows – Cell Biology (Fudan University)

Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine)

Principal Investigator/Professor Positions – Stem Cell Research (Guangzhou Institutes of Biomedicine and Health)

PhD Student – Bioprinting of Tissues (Uppsala University)

Postdoctoral Positions – Systems Biology and Metabolism (Charité – Universitätsmedizin Berlin)

Postdoctoral Fellow – Biomaterials and Nanotechnology in Regenerative Medicine (Guangzhou Medical University)

Assistant Professor – Sarcoma (McGill University)

Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

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