Mesenchymal Cell News Volume 12.21 | Jun 2 2020

TOP STORY

Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: A Randomized Clinical Trial

Researchers enrolled patients aged 18–70 years less than two weeks following moderate-severe ischemic carotid stroke. Patients were randomized 2:1 to receive intravenous MSCs or not. Primary outcomes assessed feasibility and safety. [Transl Stroke Res] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Small Extracellular Vesicles Derived from Human MSCs Prevent Allergic Airway Inflammation via Immunomodulation on Pulmonary Macrophages

Scientists investigated the effects of small extracellular vesicles derived from MSCs on allergic airway inflammation, and the role of macrophages involved in it. [Cell Death Dis] Full Article

Polydatin Improves Osteogenic Differentiation of Human Bone Mesenchymal Stem Cells by Stimulating TAZ Expression via BMP2-Wnt/β-Catenin Signaling Pathway

In vitro, 30 μM polydatin significantly improved the proliferation and calcium deposition of human bone marrow stromal cells and markedly stimulated the expression of the mRNAs RUNX2, osteopontin, DLX5, β-catenin, tafazzin (TAZ), and osteocalcin. [Stem Cell Res Ther] Full Article

TGF-β-Driven Downregulation of the Wnt/β-Catenin Transcription Factor TCF7L2/TCF4 in PDGFRα⁺ Fibroblasts

Researchers investigated whether damage-induced TGF-β impaired the expression and function of TCF7L2, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors [J Cell Sci] Abstract

Advanced Glycation End Products Inhibit the Osteogenic Differentiation Potential of Adipose-Derived Stem Cells by Modulating Wnt/β-catenin Signalling Pathway via DNA Methylation

Advanced glycation end products inhibited the osteogenic differentiation ability of adipose‐derived stem cells by activating DNA methylation and inhibiting Wnt/β‐catenin pathway in vitro. [Cell Prolif] Full Article

Oriented Immobilization of Basic Fibroblast Growth Factor: Bioengineered Surface Design for the Expansion of Human Mesenchymal Stromal Cells

The rate of human MSC proliferation was 1.2-fold higher on the basic fibroblast growth factor-immobilized surface treated with in situ citrate buffer, compared to the polystyrene surface. [Sci Rep] Full Article

Anti-DKK1 Enhances the Early Osteogenic Differentiation of Human Adipose-Derived Stem/Stromal Cells

Human adipose-derived stem cells (ASCs) were derived from N=5 samples of human lipoaspirate. In vitro, anti-Dickkopf-1 (DKK1) treatment, but not anti-Sclerostin, promoted ASC osteogenic differentiation, assessed by alizarin red staining and qRT-PCR [Stem Cells Dev] Abstract

Feasibility, Potency, and Safety of Growing Human Mesenchymal Stem Cells in Space for Clinical Application

Human-derived MSCs grown in space were evaluated to determine their potential use for future clinical applications on Earth and during long-term spaceflight. [npj Microgravity] Full Article

IN VIVO

Intravenous Infusion of Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells as a Potential Treatment for Patients with COVID-19 Pneumonia

Investigators report a case of a severe COVID-19 patient treated with human umbilical cord Wharton’s jelly-derived MSCs from a healthy donor. [Stem Cell Res Ther] Full Article

Mesenchymal Stem Cell-Derived Exosomes Improve Functional Recovery in Rats after Traumatic Brain Injury: A Dose-Response and Therapeutic Window Study

Compared with the vehicle, regardless of the dose and delay in treatment, exosome treatment significantly improved sensorimotor and cognitive function, reduced hippocampal neuronal cell loss, promoted angiogenesis and neurogenesis, and reduced neuroinflammation. [Neurorehabil Neural Repair] Abstract

Mesenchymal Stromal Cells Induce Distinct Myeloid-Derived Suppressor Cells in Inflammation

MSCs directed the differentiation of Ly6G^lo BM cells from CD11b^hiLy6C^hi to CD11b^midLy6C^mid cells both in cell contact-independent and -dependent manners upon GM-CSF stimulation in vitro and in mice with experimental autoimmune uveoretinitis. [JCI Insight] Abstract | Full Article | Graphical Abstract

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Mesenchymal Stromal Cells; A New Horizon in Regenerative Medicine

The authors provide a brief overview of MSCs sources, isolation, and expansion as well as immunomodulatory activities. [J Cell Physiol] Abstract

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AgeX Therapeutics and ImStem Biotechnology Sign Non-Binding Letter of Intent Regarding Investigational MSC Candidate IMS001 for COVID-19 and Other Causes of ARDS

AgeX Therapeutics, Inc. and ImStem Biotechnology, Inc. announced their signing of a non-binding letter of intent for ImStem to obtain from AgeX a non-exclusive license to use AgeX’s embryonic stem cell line ESI 053 to derive ImStem’s investigational MSC product IMS001 for development in COVID-19 as well as acute respiratory distress syndrome (ARDS) due to other causes. [AgeX Therapeutics, Inc. (Business Wire, Inc.)] Press Release

Longeveron Announces Japanese Approval of Clinical Trial for Treatment of Aging Frailty with Longeveron’s Stem Cells

Longeveron LLC announced that Japan’s Pharmaceutical and Medical Devices Agency approved a Clinical Trial Notification application, approving the initiation of a Phase II clinical trial evaluating the safety and efficacy of Longeveron’s MSCs for the treatment of Aging Frailty in Japanese patients. [Longeveron LLC (PR Newswire Association LLC)] Press Release

Junior Researchers Hit by Coronavirus-Triggered Hiring Freezes

Juan Manuel Vazquez thought he knew where his career would take him after he wrapped up his PhD in genetics at the University of Chicago in Illinois in May. But the COVID-19 pandemic threatened to upend his plans. [Nature News] Editorial

Sputnik Moment or Budget Breaker: How Will the Pandemic Alter Research Funding?

As the pandemic’s economic toll grows around the world, some experts fear it could harm science for decades by putting many thousands of researchers out of work and forcing nations to slash funding as they rebuild societies. [Nature News] Editorial

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NEW Postdoctoral Researcher – MSCs (National University of Ireland Galway)

NEW Postdoctoral Position – Cellular Stress Signaling (University of Copenhagen)

Researcher – Human Tissue (Fondazione Banca dei Tessuti di Treviso Onlus)

Senior Investigator – Stem Cell Biology (Institut Pasteur of Shanghai)

Postdoctoral Fellow – In Vivo Molecular and Cellular Imaging (Johns Hopkins University)

Postdoctoral Position – Bone Biology (Karolinska Institutet)

Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine)

Principal Investigators and Postdoctoral Fellows – Cell Biology (Fudan University)

Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

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