 | | Vol. 12.41 – 20 October, 2020 |
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| The authors describe the enhanced recruitment of adoptively applied theranostic sodium iodide symporter-expressing MSCs to tumors in response to regional hyperthermia.
[Molecular Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Researchers identified Tenascin C to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity.
[Oncogene] |
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| The constructed multiplex siRNAs effectively knocked down the expression of Smad4 and/or Smad1, Smad5, and Smad8 in MSCs, and inhibited all aspects of BMP9-induced osteogenic differentiation in bone marrow MSCs, including decreased expression of osteogenic regulators/markers, reduced osteogenic marker ALP activity, and diminished in vitro matrix mineralization and in vivo ectopic bone formation
[Molecular Therapy-Nucleic Acids] |
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| Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.
[Cell Death & Disease] |
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| Scientists developed a novel, highly porous, multimaterial composite, chitosan/hydroxyapatite/polycaprolactone. The in vitro studies were performed using MSCs from three tissue sources: human bone marrow‐derived MSCs, adipose‐derived MSCs, and Wharton’s jelly‐derived MSCs.
[Stem Cells Translational Medicine] |
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| The authors examined the roles of aging-associated reactive oxygen species in the function and rejuvenation of elderly MSCs by infant extracellular vesicles.
[Scientific Reports] |
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| Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived MSCs with knocked down Numb gene were treated with Huang Qi Decoction (HQD). Simultaneously, Numb gene knockdown was also performed in the WB-F344 cell line and then treated with refined HQD
[Scientific Reports] |
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| To identify the active paracrine factors released by macrophages in response to stimulation by MSC conditioned media, scientists used an antibody array; identifying increased expression of the angiogenesis-related proteins stromal cell-derived factor 1 and plasminogen activator inhibitor-1.
[American Journal of Physiology-Cell Physiology] |
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| Researchers demonstrated that treatment with exosomes derived from neural stem cells makes MSCs capable of expressing neural cell markers bypassing the generation of iPSCs.
[PLoS One] |
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| | In vitro experiments (including colony formation, CCK-8, wound healing and transwell assays) and in vivo experiments indicated that down-regulation of SNHG10 significantly suppressed the proliferation and invasion of osteosarcoma cells
[Molecular Therapy-Nucleic Acids] |
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| Researchers suggested that Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death. Muse cells might also be a promising cell source for the treatment of amyotrophic lateral sclerosis patients.
[Scientific Reports] |
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| The authors investigated the effect of a standard of care chemotherapeutic agent Doxorubicin (Dox) on MSC-exo and its contribution to the development of Dox resistance in breast cancer cells (BCs). They found that the exosome secreted by Dox-treated MSC induced a higher degree of Dox resistance in BCs when compared with non-treated MSC-exo.
[Molecular Therapy-Oncolytics] |
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| Invstigators shed light on the mechanistic view of MSC therapeutic role based on preclinical and clinical studies on acute lung injury and ARDS; therefore, offering a unique correlation and applicability in COVID-19 patients. They further highlight the challenges and opportunities in the use of MSC-based therapy.
[Stem Cell Research & Therapy] |
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| The aryl hydrocarbon receptor has potential to be an attractive target in both endogenous and culture‐adapted MSCs for novel therapeutics to treat inflammation and other age‐related disorders.
[FEBS Journal] |
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| Scientists summarize the current neuroscientific evidence regarding the effectiveness of cell therapies in Retinitis pigmentosa, especially those based on MSCs, and they focus on their therapeutic action: limitation of both oxidative stress and apoptotic processes triggered by the disease and promotion of cell survival.
[Antioxidants] |
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| Bone Therapeutics has announced positive 24-month follow-up results for the Phase IIa study with the allogeneic cell therapy product, ALLOB, in patients undergoing lumbar spinal fusion procedures. ALLOB is their off-the-shelf allogeneic cell therapy platform consisting of human allogeneic bone-forming cells derived from cultured bone marrow MSCs from healthy adult donors.
[Bone Therapeutics S.A.] |
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| March 17 – March 19, 2021
Virtual |
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| | University of Chicago – Chicago, Illinois, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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