 | | Vol. 12.42 – 27 October, 2020 |
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| Investigators showed that in patient-derived stromal cells, H3.3-G34W was incorporated into the chromatin and associated with massive epigenetic alterations on the DNA methylation, chromatin accessibility and histone modification level, that could be partially recapitulated in an orthogonal cell line system by the introduction of H3.3-G34W.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that Msh homeobox (Msx)1 promoted the proliferation of myoblasts and MSCs by enhancing mitogen-activated protein kinase (MAPK) signaling.
[Nucleic Acids Research] |
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| Researchers identified appropriate reference genes for normalization of miRNA expression in bone marrow-MSCs and HS27a and HS5 cell lines in various conditions including normoxia, hypoxia, co-culture, as model for the hematopoietic niche and after induced differentiation as model for regenerative medicine.
[Scientific Reports] |
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| This in vitro study evaluated the adhesion, proliferation and osteogenic differentiation of adipose derived MSCs (ASCs) seeded on trabecular titanium cages. ASCs adhered, proliferated and produced an abundant extracellular matrix during the three weeks of culture.
[Scientific Reports] |
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| Platelet lysate (PL) had been shown to induce chondrogenic differentiation of human umbilical cord‐derived MSCs. Scientists investigated whether long non‐coding RNA H19 was involved in this process. Human umbilical cord MSCs were isolated, identified, and cultured in 5% PL‐supplemented chondrogenic differentiation medium
[Febs Open Bio] |
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| The authors demonstrated that network plasticity independently controls MSC spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship could be shifted by inhibiting actomyosin contractility.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Umbilical cord-MSC culture was conducted under xeno- and serum-free conditions. Four patients with established bronchopulmonary dysplasia were enrolled in this study between May and December, 2018.
[Journal of Translational Medicine] |
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| To evaluate the function of MSCs located at the large intestinal crypt, scientists established a novel method through which cells were harvested according to the histologic layers of mouse colon, and compared cellular properties between microenvironmental niches, the luminal mucosa and crypts.
[Scientific Reports] |
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| Low concentration of IL‐8 peptide inhibitors (100 ng/ml) and CXC receptor 2 (CXCR2) inhibitors had little effect on the migration of bone marrow‐derived MSCs, but could effectively weaken colon cancer stem cell stemness (CSCs) and promoted dormant CSCs in the coculture system to re‐enter into the cell cycle.
[Journal of Cellular Physiology] |
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| Unlike conventional treatment, MSC therapy resulted in longer and more effective recovery. Data indicated that MSCs may be an alternative and effective approach for treatment-resistant chronic spontaneous urticaria patients.
[Stem Cell Reviews and Reports] |
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| Retinoic acid‐related orphan receptor beta (Ror β) was expressed in THP‐1 macrophages and human inflamed dental pulp stem cells during their resting stage. Upregulated expression of Ror β occurred following an anti‐inflammatory stimulus.
[International Endodontic Journal] |
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| Researchers revealed a distinct ossification-related tuberculosis lung signature, which may be associated with the activation of the BMP/SMAD/RUNX2 pathway in Mtb-infected macrophages that can restrain mycobacterial survival and promote osteogenic differentiation of MSCs.
[Communications Biology] |
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| The authors highlight the emerging role of prostate cancer (PCa)-derived extracellular vesicles in reprogramming osteoblasts and support of premetastatic niche formation. They also develop the concept of cancer-associated osteoblasts and outline the potential of PCa cells to acquire an osteoblastic phenotype, termed osteomimicry, as two strategies that PCa utilizes to create a favorable protected niche.
[Trends in Cancer] |
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| Scientists discuss key features of the current COVID-19 outbreak, and the rationale for MSC-based therapy in this setting, as well as the limitations associated with this therapeutic approach.
[NPJ Regenerative Medicine] |
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| Global Stem Cells Group (GSCG) has signed a historic agreement with Dubai-based healthcare company Bioscience Cell Factory. Through the acquisition of proprietary branding rights, GSCG will become committed to promote the widespread use of cellular therapy treatments that utilize MSCs.
[Global Stem Cells Group] |
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| Catalent and BrainStorm Cell Therapeutics Inc. announced an agreement for the manufacture of NurOwn®, BrainStorm’s autologous cellular therapy being investigated for the treatment of amyotrophic lateral sclerosis. NurOwn induces MSCs to secrete high levels of neurotrophic factors known to promote the survival of neurons and neuroprotection.
[Catalent (GlobeNewswire, Inc.)] |
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| March 17 – March 19, 2021
Virtual |
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| | National University of Ireland Galway – Galway, Ireland |
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| | University of Chicago – Chicago, Illinois, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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